CDK5RAP3 - CDK5 regulatory subunit associated protein 3 Gene

Homo sapiens

Also known as C53; IC53; LZAP; HSF-27; MST016; PP1553; OK/SW-cl.114

Gene ID: 80279 | Gene type: protein coding

About CDK5RAP3

Cytogenetic location: 17q21.32 Genomic coordinates (GRCh38): 17:47,967,904-47,981,781 (from NCBI)

This gene has 37 transcripts (splice variants) and 201 orthologues. Ubiquitous expression in spleen (RPKM 44.2), lymph node (RPKM 40.3) and 25 other tissues.

Summary

This gene encodes a protein that has been reported to function in signaling pathways governing transcriptional regulation and cell cycle progression. It may play a role in tumorigenesis and metastasis. A pseudogene of this gene is located on the long arm of chromosome 20. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, May 2013]

CDK5RAP3 Products(5)

mRNA	Protein	Name
NM_001278197.2	NP_001265126.1	CDK5 regulatory subunit-associated protein 3 isoform c
NM_001278198.2	NP_001265127.1	CDK5 regulatory subunit-associated protein 3 isoform d
NM_001278216.2	NP_001265145.1	CDK5 regulatory subunit-associated protein 3 isoform e
NM_001278217.2	NP_001265146.1	CDK5 regulatory subunit-associated protein 3 isoform f
NM_176096.3	NP_788276.1	CDK5 regulatory subunit-associated protein 3 isoform b

CDK5RAP3 Protein Structure

DUF773

0
100
200
300
400
506 a.a.

Protein Preferred Names

Protein Names

CDK5 regulatory subunit-associated protein 3

CDK5 regulatory subunit associated protein IC53-2

Related Diseases

Diseases

Alias

Beukes Hip Dysplasia

Hip Dysplasia, Beukes Type	Beukes Familial Hip Dysplasia
BFHD	Cilliers-Beighton Syndrome
Osteoarthropathy, Premature Degenerative, Of Hip	Premature Degenerative Osteoarthropathy Of The Hip
BHD	Beukes Type Hip Dysplasia
Hip Dysplasia Beukes Type	Premature Degenerative Osteoarthropathy
Dysplasia, Hip, Beukes Type

Renal Cysts And Diabetes Syndrome

RCAD	Mody5
Congenital Anomalies Of The Kidney And Urinary Tract With Diabetes	Cakut With Diabetes
Maturity-Onset Diabetes Of The Young Type 5	Tubulointerstitial Kidney Disease, Autosomal Dominant, 3
Adtkd3	Atypical Familial Juvenile Hyperuricemic Nephropathy
Atypical Fjhn	Familial Hypoplastic Glomerulocystic Kidney
Maturity-Onset Diabetes Of The Young, Type 5	Hyperuricemic Nephropathy, Familial Juvenile, Atypical
Fjhn, Atypical	Glomerulocystic Kidney Disease, Hypoplastic Type
Glomerulocystic Kidney, Familial Hypoplastic	Hypoplastic Type Glomerulocystic Kidney Disease
Glomerulocystic Kidney Disease Hypoplastic Type	Renal-Diabetes Mody5 Syndrome

Maturity-Onset Diabetes Of The Young

MODY	Maturity Onset Diabetes Mellitus In Young
Mason-Type Diabetes	Mason Type Diabetes
Maturity Onset Diabetes Of The Young	Mody Syndrome
Diabetes Of The Young, Maturity-Onset

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02391	CDK5RAP3 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CDK5RAP3	RGD	RGD:620002
Bos taurus	CDK5RAP3	VGNC	VGNC:27132
Macaca mulatta	CDK5RAP3	VGNC	VGNC:71015
Felis catus	CDK5RAP3	VGNC	VGNC:60704
Canis familiaris	CDK5RAP3	VGNC	VGNC:39059
Mus musculus	CDK5RAP3	MGD	MGI:1933126

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