UFC1 - ubiquitin-fold modifier conjugating enzyme 1 Gene

Also Known as NEDSG; HSPC155

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 51506

About UFC1

Cytogenetic location: 1q23.3 Genomic coordinates (GRCh38): 1:161,153,978-161,158,856 (from NCBI)

This gene has 6 transcripts (splice variants), 196 orthologues and is associated with 2 phenotypes. Ubiquitous expression in urinary bladder (RPKM 37.2), ovary (RPKM 36.8) and 25 other tissues.

Summary

UFC1 is an E2-like conjugating enzyme for ubiquitin-fold modifier-1 (UFM1; MIM 610553) (Komatsu et al., 2004 [PubMed 15071506]).[supplied by OMIM, Mar 2008]

UFC1 Products (1)

mRNA Protein Name
NM_016406.4 NP_057490.2 ubiquitin-fold modifier-conjugating enzyme 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables UFM1 conjugating enzyme activity IDA
IDA: Inferred from direct assay
15071506 GOA
enables UFM1 conjugating enzyme activity IMP
IMP: Inferred from mutant phenotype
37036982 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
20018847 GOA
Biological Process GO Annotation Evidence References Source
involved in brain development IMP
IMP: Inferred from mutant phenotype
29868776 GOA
involved in protein K69-linked ufmylation IDA
IDA: Inferred from direct assay
25219498 GOA
involved in protein ufmylation IDA
IDA: Inferred from direct assay
15071506 GOA
acts upstream of or within protein ufmylation IMP
IMP: Inferred from mutant phenotype
23152784 GOA
involved in protein ufmylation IMP
IMP: Inferred from mutant phenotype
29868776 GOA
acts upstream of or within response to endoplasmic reticulum stress IDA
IDA: Inferred from direct assay
23152784 GOA
involved in response to endoplasmic reticulum stress IMP
IMP: Inferred from mutant phenotype
32160526 GOA
involved in reticulophagy IMP
IMP: Inferred from mutant phenotype
32160526 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UFC1 Protein Structure

UFC1

UFC1: Ubiquitin-fold modifier-conjugating enzyme 1 (5 - 164)

  • 0
  • 100
  • 167 a.a.
Protein Preferred Names Protein Names

ubiquitin-fold modifier-conjugating enzyme 1

  • Ufm1-conjugating enzyme 1

UFC1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
UFC1 Q9Y3C8 UFL1 Homo sapiens O94874
Pull Down
37595036
Intra
UFC1 Q9Y3C8 UFL1 Homo sapiens O94874
Anti Tag CoIP
37595036
Intra
UFC1 Q9Y3C8 ANKRD11 Homo sapiens X5D778
Validated Y2H
32296183
Intra
UFC1 Q9Y3C8 GEMIN4 Homo sapiens P57678
Y2H Prey Pooling
32296183
Intra
UFC1 Q9Y3C8 GEMIN4 Homo sapiens P57678
Y2H Array
32296183
Intra
UFC1 Q9Y3C8 CDK5RAP3 Homo sapiens Q96JB5
Anti Tag CoIP
37595036
Cross: Cross-species interaction Intra: Intraspecies interaction

UFC1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82602 UFC1 Antibody (YA2347) WB, IHC-P Human, Mouse, Rat
HY-P82602A UFC1 Antibody (YA2347)(PBS only) WB, IHC-P Human, Mouse, Rat

Related Diseases

Diseases Alias
Neurodevelopmental Disorder With Spasticity And Poor Growth

  • NEDSG
Osteoarthritis

  • Osteoarthrosis

  • Degenerative Joint Disease

  • Hypertrophic Arthritis

  • Arthropathy

  • Degenerative Polyarthritis

  • Degenerative Arthritis

  • Osteoarthrosis And Allied Disorder

  • Arthritis, Degenerative

  • Oa

  • Osteoarthritis Deformans

  • Osteoarthrosis Deformans

  • Kashin-Beck Disease
Hepatocellular Carcinoma

  • Liver Cancer

  • Primary Liver Cancer

  • HCC

  • Hepatoma

  • Malignant Neoplasm Of Liver

  • Liver Neoplasms

  • Cancer, Hepatocellular

  • Liver Cell Carcinoma

  • Lcc

  • Hepatoblastoma, Somatic

  • Hepatic Cancer

  • Primary Malignant Neoplasm Of Liver

  • Rare Tumor Of Liver And Intrahepatic Biliary Tract

  • Hepatocellular Carcinoma, Somatic

  • Hepatocellular Carcinoma, Childhood Type, Somatic

  • Hepatocellular Cancer, Somatic

  • Ca Liver - Primary

  • Hepatic Neoplasm

  • Malignant Hepato-Biliary Neoplasm

  • Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

  • Malignant Neoplasm Of Liver, Primary

  • Malignant Tumor Of Liver

  • Neoplasm Of Liver

  • Non-Resectable Primary Hepatic Malignant Neoplasm

  • Resectable Malignant Neoplasm Of Liver

  • Resectable Malignant Neoplasm Of The Liver

  • Primary Liver Carcinoma

  • Primary Malignant Liver Neoplasm

  • Primary Cancer Of Liver

  • Primary Tumor Of The Liver

  • Rare Tumor Of Liver And Ibt

  • Hepatocellular Cancer

  • Neoplasm Of The Liver

  • Carcinoma, Hepatocellular

  • Hepatomas

  • Liver Neoplasm

  • Liver Carcinoma

  • Liver And Intrahepatic Biliary Tract Carcinoma

  • Malignant Hepatobiliary Neoplasm

  • Adult Primary Hepatocellular Carcinoma

  • Hepatoblastoma

  • Carcinoma Of Liver

  • Malignant Liver Tumour

  • Malignant Hepatic Tumour
Spinocerebellar Ataxia, Autosomal Recessive 24

  • SCAR24

  • Autosomal Recessive Spinocerebellar Ataxia 24

  • Spinocerebellar Ataxia, Autosomal Recessive, 24

  • Ataxia, Spinocerebellar, Autosomal Recessive, Type 24
Beukes Hip Dysplasia

  • Hip Dysplasia, Beukes Type

  • Beukes Familial Hip Dysplasia

  • BFHD

  • Cilliers-Beighton Syndrome

  • Osteoarthropathy, Premature Degenerative, Of Hip

  • Premature Degenerative Osteoarthropathy Of The Hip

  • BHD

  • Beukes Type Hip Dysplasia

  • Hip Dysplasia Beukes Type

  • Premature Degenerative Osteoarthropathy

  • Dysplasia, Hip, Beukes Type
Developmental And Epileptic Encephalopathy 44

  • DEE44

  • Epileptic Encephalopathy, Early Infantile, 44

  • Eiee44

  • Developmental And Epileptic Encephalopathy, 44

  • Early Infantile Epileptic Encephalopathy 44

  • Encephalopathy, Epileptic, Early Infantile, Type 44
Microcephaly

  • Microencephaly

  • Microcephalus

  • Microcephalic

  • Nanocephaly

  • Congenital Microcephaly

  • Brain Hypoplasia

  • Brain Nondevelopment

  • Cephalic Hypoplasia

  • Undeveloped Cerebrum

  • Undeveloped Brain

  • Micrencephalon

  • Micrencephaly
Maturity-Onset Diabetes Of The Young

  • MODY

  • Maturity Onset Diabetes Mellitus In Young

  • Mason-Type Diabetes

  • Mason Type Diabetes

  • Maturity Onset Diabetes Of The Young

  • Mody Syndrome

  • Diabetes Of The Young, Maturity-Onset
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15413 UFC1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus UFC1 MGD MGI:1913405
Canis familiaris UFC1 VGNC VGNC:48113
Rattus norvegicus UFC1 RGD RGD:1303313
Bos taurus UFC1 VGNC VGNC:36644
Felis catus UFC1 VGNC VGNC:103758
Macaca mulatta UFC1 VGNC VGNC:79643
Others UFC1 NCBI