Grk1 - G protein-coupled receptor kinase 1 Gene

Also Known as Rhok

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 81760

Summary

Enables rhodopsin kinase activity. Involved in protein autophosphorylation; response to light stimulus; and response to xenobiotic stimulus. Predicted to be located in photoreceptor outer segment. Predicted to be active in cytoplasm. Used to study congestive heart failure. Biomarker of retinal disease. Human ortholog(s) of this gene implicated in Oguchi disease-2 and night blindness. Orthologous to human GRK1 (G protein-coupled receptor kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Grk1 Products (1)

mRNA Protein Name
NM_031096.1 NP_112358.1 rhodopsin kinase GRK1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables rhodopsin kinase activity IDA
IDA: Inferred from direct assay
2402884 RGD
Biological Process GO Annotation Evidence References Source
involved in protein autophosphorylation IDA
IDA: Inferred from direct assay
1550556 RGD
involved in response to light stimulus IEP
IEP: Inferred from expression pattern
3950623 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
11923229 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

rhodopsin kinase GRK1

  • G protein-coupled receptpr kinase 1

  • RK

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (10)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-103045 CMPD101 Inhibitor 98.96% Unkown
HY-142812 GRK6-IN-1 99.61% Unkown
HY-18991 CCG215022 Inhibitor 99.79% Unkown
HY-109562A CCG258208 hydrochloride 98.05% Unkown
HY-139690 CCG258747 98.96% Unkown
HY-109562 CCG258208 Inhibitor / Unkown
HY-118046 GSK2163632A Inhibitor / Unkown
HY-119232 GSK466317A Inhibitor / Unkown
HY-120168 CCG 258001 Inhibitor / Unkown
HY-RS05812 GRK1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Grk1 NCBI NCBI:6011