Tfcp2l1 - transcription factor CP2-like 1 Gene

Mus musculus

Also known as Cp2l1; LBP-9; Crtr-1; Tcfcp2l1; 1810030F05Rik; 4932442M07Rik; D930018N21Rik

Gene ID: 81879 | Gene type: protein coding

About Tfcp2l1

Summary

Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including determination of adult lifespan; epithelial cell maturation; and negative regulation of transcription by RNA polymerase II. Located in cytoplasm; membrane; and nucleus. Is expressed in early conceptus; genitourinary system; heart; and limb. Orthologous to human TFCP2L1 (transcription factor CP2 like 1). [provided by Alliance of Genome Resources, Apr 2022]

Tfcp2l1 Products(1)

mRNA	Protein	Name
NM_023755.2	NP_076244.2	transcription factor CP2-like protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	20661472	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	20362541	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within cell morphogenesis	IMP IMP: Inferred from mutant phenotype	17079272	MGI
acts upstream of or within cytoplasm organization	IMP IMP: Inferred from mutant phenotype	17079272	MGI
acts upstream of or within determination of adult lifespan	IMP IMP: Inferred from mutant phenotype	17079272	MGI
acts upstream of or within epithelial cell maturation	IMP IMP: Inferred from mutant phenotype	17079272	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	11073954	MGI
acts upstream of or within positive regulation of growth	IMP IMP: Inferred from mutant phenotype	17079272	MGI
acts upstream of or within salivary gland development	IMP IMP: Inferred from mutant phenotype	17079272	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	17079272	MGI
located in membrane	IDA IDA: Inferred from direct assay	17079272	MGI
located in nucleus	IDA IDA: Inferred from direct assay	17079272	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

transcription factor CP2-like protein 1

CP2-related transcriptional repressor 1	Tcfcp2-related transcriptional repressor 1
transcription repressor CRTR-1

Tfcp2l1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Tfcp2l1	Q3UNW5	Esrrb	Mus musculus	Q61539	Anti Tag CoIP	20362541
Intra	Tfcp2l1	Q3UNW5	Esrrb	Mus musculus	Q61539	Pull Down	20362541

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12834A	MK2-IN-1 hydrochloride	Inhibitor	98.36%	Unkown
HY-12834	MK2-IN-1	Inhibitor	99.04%	Unkown
HY-162934	TFCP2L1-IN-1	Inducer	99.66%	Unkown
HY-RS14416	TFCP2L1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tfcp2l1	NCBI	NCBI:29842

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