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TFCP2L1 - transcription factor CP2 like 1 Gene

Also Known as LBP9; CRTR1; LBP-9

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 29842

About TFCP2L1

Cytogenetic location: 2q14.2 Genomic coordinates (GRCh38): 2:121,216,587-121,285,202 (from NCBI)

This gene has 2 transcripts (splice variants), 196 orthologues and 5 paralogues. Biased expression in kidney (RPKM 25.1), salivary gland (RPKM 23.9) and 10 other tissues.

Summary

Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm and membrane. Predicted to be part of chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

TFCP2L1 Products (1)

mRNA	Protein	Name
NM_014553.3	NP_055368.1	transcription factor CP2-like protein 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	10644752	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	10644752	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TFCP2L1 Protein Structure

CP2

0
100
200
300
400
479 a.a.

Protein Preferred Names	Protein Names
transcription factor CP2-like protein 1	CP2-related transcriptional repressor 1

Related Diseases

Diseases	Alias
Chronic Kidney Disease	Chronic Renal Disease Chronic Kidney Failure Ckd Chronic Renal Failure Kidney Failure, Chronic Chronic Renal Failure Syndrome Crf Renal Failure - Chronic Renal Failure Chronic Chronic Kidney Diseases Chronic Kidney Disease Stage 5 Ckd - [Chronic Kidney Disease] Crf - [Chronic Renal Failure] Chronic Kidney Impairment Chronic Renal Impairment Chronic Kidney Shutdown Chronic Hypoxic Kidney Failure Chronic Kidney Collapse Chronic Renal Insufficiency Chronic Kidney Toxaemia Chronic Kidney Hypofunction Chronic Renal Suppression Chronic Renal Failure, Stage 5 Ckd - [Chronic Kidney Disease] Stage 5 End Stage Kidney Failure End Stage Renal Failure End Stage Kidney Disease End Stage Renal Disease End Stage Chronic Renal Failure Esrf - [End Stage Renal Failure] Esrd - [End Stage Renal Diseases] Egfr - [Estimated Glomerular Filtration Rate] < 15 Ml/Min/1.73m²

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12834A	MK2-IN-1 hydrochloride	Inhibitor	98.36%	Unkown
HY-12834	MK2-IN-1	Inhibitor	99.04%	Unkown
HY-162934	TFCP2L1-IN-1	Inducer	99.66%	Unkown
HY-RS14416	TFCP2L1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	TFCP2L1	MGD	MGI:2444691
Bos taurus	TFCP2L1	VGNC	VGNC:35785
Felis catus	TFCP2L1	VGNC	VGNC:66114
Macaca mulatta	TFCP2L1	VGNC	VGNC:78405
Canis familiaris	TFCP2L1	VGNC	VGNC:47291
Rattus norvegicus	TFCP2L1	RGD	RGD:1305456