ALKBH6 - alkB homolog 6 Gene

Also Known as ABH6

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 84964

About ALKBH6

Cytogenetic location: 19q13.12 Genomic coordinates (GRCh38): 19:36,009,120-36,014,239 (from NCBI)

This gene has 19 transcripts (splice variants), 179 orthologues and 2 paralogues. Ubiquitous expression in brain (RPKM 5.2), spleen (RPKM 4.9) and 25 other tissues.

Summary

Predicted to enable dioxygenase activity and metal ion binding activity. Located in focal adhesion and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

ALKBH6 Products (5)

mRNA Protein Name
NM_001297701.2 NP_001284630.1 alpha-ketoglutarate-dependent dioxygenase alkB homolog 6 isoform 3
NM_001386055.1 NP_001372984.1 alpha-ketoglutarate-dependent dioxygenase alkB homolog 6 isoform 3
NM_001386056.1 NP_001372985.1 alpha-ketoglutarate-dependent dioxygenase alkB homolog 6 isoform 4
NM_032878.5 NP_116267.4 alpha-ketoglutarate-dependent dioxygenase alkB homolog 6 isoform 3
NM_198867.1 NP_942567.1 alpha-ketoglutarate-dependent dioxygenase alkB homolog 6 isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
22948820 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ALKBH6 Protein Structure

2OG-FeII_Oxy_2

2OG-FeII_Oxy_2: 2OG-Fe(II) oxygenase superfamily (73 - 224)

  • 0
  • 100
  • 200
  • 238 a.a.
Protein Preferred Names Protein Names

alpha-ketoglutarate-dependent dioxygenase alkB homolog 6

  • alkB, alkylation repair homolog 6

Related Diseases

Diseases Alias
Noonan Syndrome 5

  • NS5

  • Noonan Syndrome, Type 5
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00607 ALKBH6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris ALKBH6 VGNC VGNC:37806
Mus musculus ALKBH6 MGD MGI:2142037
Rattus norvegicus ALKBH6 RGD RGD:1566318
Macaca mulatta ALKBH6 VGNC VGNC:69726
Bos taurus ALKBH6 VGNC VGNC:25837
Others ALKBH6 NCBI