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ACY3 - aminoacylase 3 Gene

Also Known as ACY-3; HCBP1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 91703

About ACY3

Cytogenetic location: 11q13.2 Genomic coordinates (GRCh38): 11:67,642,555-67,650,730 (from NCBI)

This gene has 2 transcripts (splice variants), 232 orthologues and 1 paralogue. Biased expression in kidney (RPKM 28.0), duodenum (RPKM 26.6) and 8 other tissues.

Summary

Predicted to enable aminoacylase activity. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]

ACY3 Products (1)

mRNA	Protein	Name
NM_080658.2	NP_542389.1	N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming)

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21516116	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ACY3 Protein Structure

AstE_AspA

0
100
200
300
319 a.a.

Protein Preferred Names	Protein Names
N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming)	HCV core-binding protein 1

ACY3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ACY3	Q96HD9	KRTAP10-8	Homo sapiens	P60410	Y2H Prey Pooling	25416956
Intra	ACY3	Q96HD9	KRTAP10-8	Homo sapiens	P60410	Y2H Array	25416956
Intra	ACY3	Q96HD9	PMM2	Homo sapiens	O15305	Validated Y2H	25416956
Intra	ACY3	Q96HD9	AAMDC	Homo sapiens	Q9H7C9	Validated Y2H	25416956
Intra	ACY3	Q96HD9	AAMDC	Homo sapiens	Q9H7C9	Y2H Array	25416956
Intra	ACY3	Q96HD9	KRTAP15-1	Homo sapiens	Q3LI76	Y2H Array	32296183
Intra	ACY3	Q96HD9	KRTAP15-1	Homo sapiens	Q3LI76	Y2H Prey Pooling	32296183
Intra	ACY3	Q96HD9	PIAS2	Homo sapiens	O75928	Y2H Prey Pooling	25416956
Intra	ACY3	Q96HD9	PIAS2	Homo sapiens	O75928	Validated Y2H	25416956
Intra	ACY3	Q96HD9	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183
Intra	ACY3	Q96HD9	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183
Intra	ACY3	Q96HD9	KRTAP26-1	Homo sapiens	Q6PEX3	Y2H Prey Pooling	32296183
Intra	ACY3	Q96HD9	KRTAP26-1	Homo sapiens	Q6PEX3	Y2H Array	32296183
Intra	ACY3	Q96HD9	ARF5	Homo sapiens	P84085	Y2H Array	32296183
Intra	ACY3	Q96HD9	INCA1	Homo sapiens	Q0VD86	Y2H Prey Pooling	32296183
Intra	ACY3	Q96HD9	INCA1	Homo sapiens	Q0VD86	Y2H Array	32296183
Intra	ACY3	Q96HD9	GORASP2	Homo sapiens	Q9H8Y8	Validated Y2H	25416956
Intra	ACY3	Q96HD9	GORASP2	Homo sapiens	Q9H8Y8	Y2H Prey Pooling	32296183
Intra	ACY3	Q96HD9	GORASP2	Homo sapiens	Q9H8Y8	Validated Y2H	32296183
Intra	ACY3	Q96HD9	GORASP2	Homo sapiens	Q9H8Y8	Y2H Array	25416956
Intra	ACY3	Q96HD9	GORASP2	Homo sapiens	Q9H8Y8	Y2H Array	32296183
Intra	ACY3	Q96HD9	GORASP2	Homo sapiens	Q9H8Y8	Y2H Array	29892012
Intra	ACY3	Q96HD9	GORASP2	Homo sapiens	Q9H8Y8	Y2H	21516116
Intra	ACY3	Q96HD9	GORASP2	Homo sapiens	Q9H8Y8	Y2H Array	31515488
Intra	ACY3	Q96HD9	LNX1	Homo sapiens	Q8TBB1	Validated Y2H	25416956
Intra	ACY3	Q96HD9	LNX1	Homo sapiens	Q8TBB1	Y2H Array	25416956
Intra	ACY3	Q96HD9	LNX1	Homo sapiens	Q8TBB1	Y2H Prey Pooling	25416956
Intra	ACY3	Q96HD9	DDIT4L	Homo sapiens	Q96D03	Y2H Array	32296183
Intra	ACY3	Q96HD9	DDIT4L	Homo sapiens	Q96D03	Y2H Prey Pooling	32296183
Intra	ACY3	Q96HD9	PLEKHF2	Homo sapiens	Q9H8W4	Validated Y2H	25416956
Intra	ACY3	Q96HD9	PLEKHF2	Homo sapiens	Q9H8W4	Y2H Prey Pooling	25416956
Intra	ACY3	Q96HD9	ASPA	Homo sapiens	P45381	Y2H Array	25416956
Intra	ACY3	Q96HD9	ASPA	Homo sapiens	P45381	Y2H Array	32296183
Intra	ACY3	Q96HD9	NOTCH2NLA	Homo sapiens	Q7Z3S9	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ACY3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7457	ACY3 Protein, Human (His)	Q96HD9 (M1-S319)	≥ 80%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Hepatitis C Virus	Hepatitis C Virus, Susceptibility To Hepatitis C Virus Infection, Response To Therapy Of Hcv Hcv, Susceptibility To Hepatitis C Virus, Resistance To Hepatitis C Virus, Response To Therapy Of Resistance To Hepatitis C Virus
Canavan Disease	Aspartoacylase Deficiency Aminoacylase 2 Deficiency Spongy Degeneration Of Central Nervous System Aspa Deficiency Acy2 Deficiency Canavan-Van Bogaert-Bertrand Disease Mild Canavan Disease Asp Deficiency Spongy Degeneration Of The Central Nervous System Severe Canavan Disease Von Bogaert-Bertrand Disease Canavan'S Disease Spongy Degeneration Of The Brain Juvenile Canavan Disease Infantile Canavan Disease Neonatal Canavan Disease CAND Disease, Canavan Canavan Disease, Juvenile Canavan Disease, Infantile Canavan Disease, Neonatal
Leukodystrophy, Hypomyelinating, 2	Pmld1 Hypomyelinating Leukodystrophy 2 HLD2 Pelizaeus-Merzbacher-Like Disease 1 Pelizaeus-Merzbacher-Like Disease Due To Gjc2 Mutation Pelizaeus-Merzbacher-Like Disease Type 1 Pelizaeus-Merzbacher-Like Disease, 1 Pelizaeus Merzbacher Like Disease Pelizaeus-Merzbacher-Like Disease Pmld - Pelizaeus Merzbacher Like Disease Pelizaeus-Merzbacher-Like Disease Autosomal Recessive Type 1 Pmldar1 Leukodystrophy, Hypomyelinating, Type 2

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-NP042	Protein A-Cy3		/	Unkown
HY-NP164N	Concanavalin A-Cy3		/	Unkown
HY-RS00255	ACY3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19115	Acy3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25605	Acy3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ACY3	RGD	RGD:1305394
Macaca mulatta	ACY3	VGNC	VGNC:99538
Mus musculus	ACY3	MGD	MGI:1918920
Others	ACY3	NCBI