ACY3 Protein, Human (His)
ACY3 Protein, Human (His) is human recombinant ACY3 with a N-terminal His tag. ACY3 Protein, Human (His) plays an important role in deacetylating mercapturic acids in kidney proximal tubules.
- Species: Human
- Source: E. coli
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- References
- Help & FAQs
Biological Activity
Description
ACY3 Protein, Human (His) is human recombinant ACY3 with a N-terminal His tag. ACY3 Protein, Human (His) plays an important role in deacetylating mercapturic acids in kidney proximal tubules[1][2].
Background
ACY3 (Aspartoacylase 3) is an aspartoacylase, and locates at 11q13.2. The length of its sequence is 959 bases, encoding 319aa. ACY3 plays an important role in deacetylating mercapturic acids in kidney proximal tubules. ACY3 mediates deacetylation of N-acetyl-Lamino acids to give fatty acids and amino acids as products. ACY3 also deacetylated N-acetyl-L-histidine and N-acetyl-L-methionine. ACY3 is capable of binding to HCV core protein[1][2].
Technical Parameters
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Species Human
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Source E. coli
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Tag N-6*His
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Accession
Q96HD9 (M1-S319)
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Molecular Construction
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N-term
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6*His
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ACY3 (M1-S319)
Accession # Q96HD9 -
C-term
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Protein Length
Full Length
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Synonyms
ACY3; Aspartoacylase (Aminoacylase) 3; Aminoacylase 3; HCV Core-Binding Protein 1; ASPA2; Acylase III; ACY-3; MGC9740; HCBP1; N-Acyl-Aromatic-L-Amino Acid Amidohydrolase; Aspartoacylase-2; Aspartoacylase (Aminocyclase) 3; N-Acyl-Aromatic-L-Amino Acid Amid
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AA Sequence
MCSLPVPREPLRRVAVTGGTHGNEMSGVYLARHWLHAPAELQRASFSAVPVLANPAATSGCRRYVDHDLNRTFTSSFLNSRPTPDDPYEVTRARELNQLLGPKASGQAFDFVLDLHNTTANMGTCLIAKSSHEVFAMHLCRHLQLQYPELSCQVFLYQRSGEESYNLDSVAKNGLGLELGPQPQGVLRADIFSRMRTLVATVLDFIELFNQGTAFPAFEMEAYRPVGVVDFPRTEAGHLAGTVHPQLQDRDFQPLQPGAPIFQMFSGEDLLYEGESTVYPVFINEAAYYEKGVAFVQTEKFTFTVPAMPALTPAPSPAS
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Predicted Molecular Mass
37.4 kDa
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Molecular Weight
Approximately 35 kDa, based on SDS-PAGE under reducing conditions.
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Purity
≥ 80%, as determined by reducing SDS-PAGE.
Product Properties
Solution
<1 EU/μg, determined by LAL method.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
References
[1]. Chen YR, et al. Identification of a novel protein binding to hepatitis C virus core protein. J Gastroenterol Hepatol. 2009 Jul;24(7):1300-4. [Content Brief]
[2]. Newman D, et al.Specificity of aminoacylase III-mediated deacetylation of mercapturic acids. Drug Metab Dispos. 2007 Jan;35(1):43-50. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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