ARF5 - ADP ribosylation factor 5 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 381

About ARF5

Cytogenetic location: 7q32.1 Genomic coordinates (GRCh38): 7:127,588,411-127,591,700 (from NCBI)

This gene has 6 transcripts (splice variants), 235 orthologues and 30 paralogues. Ubiquitous expression in esophagus (RPKM 84.6), skin (RPKM 63.4) and 25 other tissues.

Summary

This gene is a member of the human ADP-ribosylation factor (ARF) gene family. These genes encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of Phospholipase D. The gene products include 6 ARF proteins and 11 ARF-like proteins and constitute 1 family of the Ras superfamily. The ARF proteins are categorized as class I (ARF1, ARF2,and ARF3), class II (ARF4 and ARF5) and class III (ARF6). The members of each class share a common gene organization. [provided by RefSeq, Dec 2010]

ARF5 Products (1)

mRNA Protein Name
NM_001662.4 NP_001653.1 ADP-ribosylation factor 5

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
17030804 GOA
Biological Process GO Annotation Evidence References Source
involved in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IGI
IGI: Inferred from genetic interaction
24768165 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARF5 Protein Structure

Arf

Arf: ADP-ribosylation factor family (7 - 176)

  • 0
  • 100
  • 180 a.a.
Protein Preferred Names Protein Names

ADP-ribosylation factor 5

ARF5 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ARF5 P84085 DTX3 Homo sapiens Q8N9I9
Validated Y2H
32296183
Intra
ARF5 P84085 DTX3 Homo sapiens Q8N9I9
Y2H Array
32296183
Intra
ARF5 P84085 DTX3 Homo sapiens Q8N9I9
Y2H Prey Pooling
32296183
Intra
ARF5 P84085 ACY3 Homo sapiens Q96HD9
Validated Y2H
32296183
Intra
ARF5 P84085 ACY3 Homo sapiens Q96HD9
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

ARF5 Antibodies

Cat. No. Product Name Application Reactivity
HY-P83091 ARF5 Antibody (YA2836) WB, FC Human, Mouse, Rat

Related Diseases

Diseases Alias
Cholera

  • Vibrio Cholerae Infection

  • Cholera - Vibrio Cholerae

  • Cholera Due To Vibrio Cholerae

  • Vibrio Cholerae

  • Cholera Syndrome

  • Asiatic Cholera

  • Epidemic Cholera
Geroderma Osteodysplasticum

  • Gerodermia Osteodysplastica

  • Geroderma Osteodysplastica

  • GO

  • Walt Disney Dwarfism

  • Type Of Gerodermia Osteodysplastica
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00897 ARF5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22106 Arf5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28627 Arf5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus ARF5 VGNC VGNC:68041
Mus musculus ARF5 MGD MGI:99434
Macaca mulatta ARF5 VGNC VGNC:80792
Canis familiaris ARF5 VGNC VGNC:54754
Rattus norvegicus ARF5 RGD RGD:621278
Bos taurus ARF5 VGNC VGNC:26060
Others ARF5 NCBI