SLC28A1 - solute carrier family 28 member 1 Gene

Also Known as CNT1; HCNT1; URCTU

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9154

About SLC28A1

Cytogenetic location: 15q25.3 Genomic coordinates (GRCh38): 15:84,884,662-84,975,649 (from NCBI)

This gene has 4 transcripts (splice variants), 198 orthologues, 2 paralogues and is associated with 1 phenotype. Biased expression in kidney (RPKM 9.5), small intestine (RPKM 9.4) and 2 other tissues.

Summary

Enables azole transmembrane transporter activity; cytidine transmembrane transporter activity; and uridine transmembrane transporter activity. Involved in azole transmembrane transport; nucleoside transport; and pyrimidine-containing compound transmembrane transport. Located in cytosol; nuclear speck; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

SLC28A1 Products (6)

mRNA	Protein	Name
NM_001287761.2	NP_001274690.1	sodium/nucleoside cotransporter 1 isoform 3
NM_001287762.2	NP_001274691.1	sodium/nucleoside cotransporter 1 isoform 1
NM_001321721.2	NP_001308650.1	sodium/nucleoside cotransporter 1 isoform 4
NM_001321722.2	NP_001308651.1	sodium/nucleoside cotransporter 1 isoform 5
NM_004213.5	NP_004204.3	sodium/nucleoside cotransporter 1 isoform 1
NM_201651.3	NP_964014.1	sodium/nucleoside cotransporter 1 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables azole transmembrane transporter activity	IDA IDA: Inferred from direct assay	22813716	GOA
enables pyrimidine- and adenosine-specific:sodium symporter activity	IDA IDA: Inferred from direct assay	9124315	GOA
enables uridine transmembrane transporter activity	IDA IDA: Inferred from direct assay	22492015	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in azole transmembrane transport	IDA IDA: Inferred from direct assay	22813716	GOA
involved in cytidine transport	IDA IDA: Inferred from direct assay	21998139	GOA
involved in nucleoside import across plasma membrane	IMP IMP: Inferred from mutant phenotype	30847922	GOA
involved in nucleoside transmembrane transport	IDA IDA: Inferred from direct assay	22492015	GOA
involved in pyrimidine-containing compound transmembrane transport	IDA IDA: Inferred from direct assay	22492015	GOA
involved in uridine transmembrane transport	IDA IDA: Inferred from direct assay	21998139	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	21998139	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	9124315	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC28A1 Protein Structure

Nucleos_tra2_N

Gate

Nucleos_tra2_C

0
100
200
300
400
500
600
649 a.a.

Protein Preferred Names	Protein Names
sodium/nucleoside cotransporter 1	Na(+)/nucleoside cotransporter 1

Related Diseases

Diseases	Alias
Uridine-Cytidineuria	URCTU

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13150	SLC28A1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	SLC28A1	VGNC	VGNC:34791
Rattus norvegicus	SLC28A1	RGD	RGD:621223
Felis catus	SLC28A1	VGNC	VGNC:65294
Mus musculus	SLC28A1	MGD	MGI:3605073
Macaca mulatta	SLC28A1	VGNC	VGNC:77444