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Cat. No.: HY-157426

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PROTAC BET Degrader-19

PROTAC BET Degrader-19 (Pro-2) is a CRBN-based PROTAC degrader for BRD, with a DC₅₀ of 21.1 nM (4h).
(Pink: BRD4 ligand (HY-78695); Blue: Cereblon ligand (HY-138793); Black: linker).

For research use only. We do not sell to patients.

CAS No.: 3093737-33-5
Formula: C₃₉H₄₁ClN₈O₄S
Molecular Weight:753.31

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

PROTAC BET Degrader-19 Chemical Structure

CAS No.: 3093737-33-5

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Sample (0.1mg)

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

PROTAC BET Degrader-19 (Pro-2) is a CRBN-based PROTAC degrader for BRD, with a DC₅₀ of 21.1 nM (4h)^[1]. (Pink: BRD4 ligand (HY-78695); Blue: Cereblon ligand (HY-138793); Black: linker).

All PROTACs Isoforms :

All Epigenetic Reader Domain Isoforms :

Chemical Information

CAS No. 3093737-33-5
Molecular Weight 753.31
Formula C₃₉H₄₁ClN₈O₄S
SMILES

O=C(NC1=O)CCC1N2CC3=CC(C4CCN(CCNC(C[C@@H](C5=NN=C(C)N56)N=C(C7=CC=C(Cl)C=C7)C8=C6SC(C)=C8C)=O)CC4)=CC=C3C2=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Christine M Arndt, et al. One-Pot Synthesis of Cereblon Proteolysis Targeting Chimeras via Photoinduced C(sp2)-C(sp3) Cross Coupling and Amide Formation for Proteolysis Targeting Chimera Library Synthesis. J Med Chem. 2023 Dec 28;66(24):16939-16952. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
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Chemical Information
Purity & Documentation
References

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PROTAC BET Degrader-19

All PROTACs Isoforms

All Epigenetic Reader Domain Isoforms