ピセアタンノール
Based on 25 publication(s) in Google Scholar
Piceatannol is a well-known Syk inhibitor and reduces the expression of iNOS induced by TNF. Piceatannol is an effective agent for research of acute lung injury (ALI). Piceatannol is a naturally occurring polyphenolic stilbene found in various fruits and vegetables and exhibits anticancer and anti-inflammatory properties. Piceatannol induces apoptosis in DLBCL cell lines. Piceatannol induces autophagy and apoptosis in MOLT-4 human leukemia cells.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.97%
- CAS 番号: 10083-24-6
- 分子式: C14H12O4
- 分子量:244.24
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 1 year , -20°C, 6 months
MedChemExpress(MCE)の使用を引用している文献 Piceatannol
More- Nature. 2026 Jun;654(8118):495-503. [Abstract]
- Cell. 2018 Oct 4;175(2):442-457.e23. [Abstract]
- Nat Commun. 2020 Sep 21;11(1):4765. [Abstract]
- Carbohydr Polym. 2026 Feb 15:374:124706. [Abstract]
- Carbohydr Polym. 2024 Dec 15:346:122586. [Abstract]
- Carbohydr Polym. 2023 Oct 1:317:121108. [Abstract]
- Carbohydr Polym. 2023 Apr 1:305:120533. [Abstract]
- Pharmacol Res. 2020 May;155:104751. [Abstract]
- Food Front. 2023 Jun 10.
- Phytother Res. 2025 Apr 16. [Abstract]
- Fundam Res. 2024 Apr 15.
- Cell Mol Life Sci. 2024 Sep 14;81(1):402. [Abstract]
- J Agric Food Chem. 2017 Jun 7;65(22):4384-4394. [Abstract]
- Inflammation. 2024 Dec;47(6):2196-2214. [Abstract]
- Eur J Pharmacol. 2023 Dec 5:960:176149. [Abstract]
- Int Immunopharmacol. 2022 Oct:111:109107. [Abstract]
- Sci Rep. 2025 Nov 17;15(1):40227. [Abstract]
- Chem Biol Drug Des. 2024 Feb;103(2):e14458. [Abstract]
- Naunyn Schmiedebergs Arch Pharmacol. 2024 Jan;397(1):479-496. [Abstract]
- Mol Immunol. 2022 Mar;143:105-113. [Abstract]
- Mycopathologia. 2021 Jun;186(3):341-354. [Abstract]
- Cell Physiol Biochem. 2016;38(6):2300-10. [Abstract]
- Stony Brook University. 2025.
- bioRxiv. 2025 January 18.
- Universidad Del Pais Vasco. 2023 Jun 22.
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WB
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Flow Cytometry
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Cell Imaging/Staining
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WB
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IF
Endogenous Metabolite アイソフォーム固有の製品をすべて表示
More
生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A2780 | IC50 |
41 μM
Compound: 4
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Antiproliferative activity against human A2780 cells after 2 days by Alamar Blue assay
Antiproliferative activity against human A2780 cells after 2 days by Alamar Blue assay
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[PMID: 24239390] |
| BV-2 | IC50 |
80.51 μM
Compound: 29
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Antineuroinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced NO production after 24 hrs in presence of LPS by Griess reaction based assay
Antineuroinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced NO production after 24 hrs in presence of LPS by Griess reaction based assay
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[PMID: 28911817] |
| HCT-116 | IC50 |
5 μM
Compound: Trans-Piceatannol
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Anticancer activity against human HCT-116 cells assessed as cell growth inhibition
Anticancer activity against human HCT-116 cells assessed as cell growth inhibition
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[PMID: 32485531] |
| J774 | IC50 |
13 μM
Compound: 5
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Antiinflammatory activity in mouse J774 cells assessed as reduction in LPS-induced IL6 expression after 24 hrs by ELISA
Antiinflammatory activity in mouse J774 cells assessed as reduction in LPS-induced IL6 expression after 24 hrs by ELISA
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[PMID: 29726680] |
| J774 | IC50 |
2.6 μM
Compound: 5
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Antiinflammatory activity in mouse J774 cells assessed as reduction in LPS-induced nitric oxide production after 24 hrs by Griess assay
Antiinflammatory activity in mouse J774 cells assessed as reduction in LPS-induced nitric oxide production after 24 hrs by Griess assay
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[PMID: 29726680] |
| J774 | IC50 |
4 μM
Compound: 5
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Antiinflammatory activity in mouse J774 cells assessed as reduction in LPS-induced MCP1 expression after 24 hrs by ELISA
Antiinflammatory activity in mouse J774 cells assessed as reduction in LPS-induced MCP1 expression after 24 hrs by ELISA
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[PMID: 29726680] |
| NCI-H522 | EC50 |
17 μM
Compound: Piceatannol
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Antiproliferative activity against human NCI-H522 cells after 72 hrs by WST8 assay
Antiproliferative activity against human NCI-H522 cells after 72 hrs by WST8 assay
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[PMID: 28169168] |
| NCI-H522 | EC50 |
23 μM
Compound: Piceatannol
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Antiproliferative activity against human NCI-H522 cells after 48 hrs by WST8 assay
Antiproliferative activity against human NCI-H522 cells after 48 hrs by WST8 assay
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[PMID: 28169168] |
| NCI-H522 | EC50 |
53 μM
Compound: Piceatannol
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Antiproliferative activity against human NCI-H522 cells after 24 hrs by WST8 assay
Antiproliferative activity against human NCI-H522 cells after 24 hrs by WST8 assay
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[PMID: 28169168] |
| U373-MAGI | EC50 |
21.4 μM
Compound: 1b
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Antiviral activity against HIV1 infected in human U373-MAGI cells expressing CXCR4 assessed as inhibition of viral infection preincubated for 2 hrs prior to infection followed by compound wash out measured after 48 hrs by single round replication assay
Antiviral activity against HIV1 infected in human U373-MAGI cells expressing CXCR4 assessed as inhibition of viral infection preincubated for 2 hrs prior to infection followed by compound wash out measured after 48 hrs by single round replication assay
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[PMID: 23010273] |
Piceatannol is a resveratrol metabolite[2].
SYK inhibitor Piceatannol (3.125, 6.25, 12.5, 25, and 50 μM; 72 hours) inhibits cell growth of six diffuse large B cell lymphomas (DLBCL) cell lines (SUDHL-6, U2392,DOHH2,Karpas 422, VAL, OCI Ly19) with IC50s of 18 μM, 25 μM, 37 μM, 48 μM, >50 μM and >50 μM, respectively[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Six DLBCL cell lines (Karpas 422, VAL, SUDHL-6, OCI Ly19, U2392 and DOHH2)
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Concentration:3.125, 6.25, 12.5, 25, and 50 μM
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Incubation Time:72 hours
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Result:The IC50s were 18 μM in SUDHL-6, 25 μM in U2392, 37 mM in DOHH2, 48 μM in Karpas 422 and higher than 50 μM in OCI-Ly19 and in VAL.
Piceatannol (10, 20, and 40 mg/kg) alleviates the myeloperoxidase activity and inhibits the production of iNOS and COX-2 expressions in lung tissuesinduced by lipopolysaccharide[1].
Piceatannol (10, 20, and 40 mg/kg; intraperitoneally 1 h) treatment alleviates inflammatory response by inhibiting the activation of TLR/NF-κB signaling pathway in lung tissues during acute lung injury (ALI) induced by LPS[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male C57BL/6 mice (40-50 g)[1]
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Dosage:10, 20, and 40 mg/kg
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Administration:Intraperitoneally 1 h before LPS challenge
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Result:Significantly reduced the pulmonary edema induced by LPS.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
化学情報
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CAS 番号 10083-24-6
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性状 Solid
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分子量 244.24
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分子式 C14H12O4
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Color Light yellow to khaki
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SMILES
OC1=CC=C(/C=C/C2=CC(O)=CC(O)=C2)C=C1O
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別名
Piceatannol; Astringenin; trans-Piceatannol
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 1 year -20°C 6 months
Publications (25)
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Journal Impact Factor
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Most Recent
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Nature
2026 Jun;654(8118):495-503. PMID: 42056510 -
Cell
2018 Oct 4;175(2):442-457.e23. PMID: 30290143
Piceatannol purchased from MedChemExpress. Usage Cited in: Cell. 2018 Oct 4;175(2):442-457.e23. [Abstract]
Syk inhibitors (R406 and Piceatannol) are added during the induction of trastuzumab-dependent BT-474 phagocytosis. The binding of the phagosome marker Rab7 to AIM2 in macrophages are evaluated by co-immunoprecipitation.
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Nat Commun
2020 Sep 21;11(1):4765. PMID: 32958780
Piceatannol purchased from MedChemExpress. Usage Cited in: Nat Commun. 2020 Sep 21;11(1):4765. [Abstract]
3T3-L1 adipocytes were pretreated with serum-free medium for 4 h and Piceatannol (Pice., 40 μM) for 1 h, followed by treatment with BSA or BSA-conjugated oleate (100 μM) for 30 min. Cells were harvested for immunoblotting with indicated antibodies. The results showed that Piceatannol largely abolished oleic acid-induced phosphorylation of VAV and JNK by inhibiting SYK in 3T3-L1 adipocytes.
Piceatannol purchased from MedChemExpress. Usage Cited in: Nat Commun. 2020 Sep 21;11(1):4765. [Abstract]
3T3-L1 adipocytes were pretreated with serum-free medium for 4 h and Piceatannol (40 μM) for 1 h, followed by treatment with BSA or BSA-conjugated oleate (100 μM) for 1 h. Cells were harvested for immunostaining assays.
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Carbohydr Polym
Decoding the pharmacokinetics of intravenous lentinan: A multiscale journey from the blood to hepatic Kupffer cells' lysosomes. [Abstract]2026 Feb 15:374:124706. PMID: 41371850 -
Carbohydr Polym
Insights into oral lentinan immunomodulation: Dectin-1-mediated lymphatic transport from Peyer's patch M cells to mononuclear phagocytes. [Abstract]2024 Dec 15:346:122586. PMID: 39245482 -
Carbohydr Polym
Metabolic degradation of polysaccharides from Lentinus edodes by Kupffer cells via the Dectin-1/Syk signaling pathway. [Abstract]2023 Oct 1:317:121108. PMID: 37364942 -
Carbohydr Polym
Innate immune receptors co-recognition of polysaccharides initiates multi-pathway synergistic immune response. [Abstract]2023 Apr 1:305:120533. PMID: 36737186 -
Pharmacol Res
Cardamonin retards progression of autosomal dominant polycystic kidney disease via inhibiting renal cyst growth and interstitial fibrosis. [Abstract]2020 May;155:104751. PMID: 32151678 -
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Phytother Res
Pterostilbene Exhibits Broad-Spectrum Antiviral Activity by Targeting the Enterovirus Capsid, Inactivating Viral Particles, Blocking Viral Binding, and Protecting Mice From Lethal EV-A71 Challenge. [Abstract]2025 Apr 16. PMID: 40235439 -
Piceatannol purchased from MedChemExpress. Usage Cited in: Fundam Res. 2024 Apr 15.
pSHP2 expression in Raw264.7 cells stimulated with 20 ng/mL of recombinant IL-10 for 24 h in the presence of the inhibitors PP2 (10 µM), UNC2025 (5 µM) or Piceatannol (40 µM).
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Cell Mol Life Sci
Tropomodulin1 exacerbates inflammatory response in macrophages by negatively regulating LPS-induced TLR4 endocytosis. [Abstract]2024 Sep 14;81(1):402. PMID: 39276234
Piceatannol purchased from MedChemExpress. Usage Cited in: Cell Mol Life Sci. 2024 Sep 14;81(1):402. [Abstract]
The cell surface expression of TLR4 on wild type (WT) or TOT/Tmod1−/− BMDMs as determined by flow cytometry. The BMDMs were pretreated with Piceatannol (PIC, 75 µM; 30 min), an Syk inhibitor, or solvent (DMSO), and then stimulated with LPS for 0, 30, 60, and 120 min. The data was expressed as percentage of surface TLR4 by dividing the fluorescence intensities at any time points by the fluorescence intensity at 0 min. n = 7 biological replicates. Flow cytometry data revealed that PIC (75 µM; 30 min) treatment impaired the effects of LPS on surface TLR4.
Piceatannol purchased from MedChemExpress. Usage Cited in: Cell Mol Life Sci. 2024 Sep 14;81(1):402. [Abstract]
The colocalization of TLR4 (red) with early endosome marker EEA-1 (green) in Piceatannol (PIC, 75 µM; 30 min)-pretreated WT or TOT/Tmod1−/− BMDMs at 0 and 10 min after LPS treatment as observed by confocal microscopy (left panels). The nuclei were counterstained with DAPI (blue). Scale bar = 10 μm.
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J Agric Food Chem
Resveratrol Reactivates Latent HIV through Increasing Histone Acetylation and Activating Heat Shock Factor 1. [Abstract]2017 Jun 7;65(22):4384-4394. PMID: 28471170 -
Inflammation
Oroxylin A-induced Trained Immunity Promotes LC3-associated Phagocytosis in Macrophage in Protecting Mice Against Sepsis. [Abstract]2024 Dec;47(6):2196-2214. PMID: 38739341 -
Eur J Pharmacol
Piceatannol alleviates liver ischaemia/reperfusion injury by inhibiting TLR4/NF-κB/NLRP3 in hepatic macrophages. [Abstract]2023 Dec 5:960:176149. PMID: 37866744 -
Int Immunopharmacol
Piceatannol-mediated JAK2/STAT3 signaling pathway inhibition contributes to the alleviation of oxidative injury and collagen synthesis during pulmonary fibrosis. [Abstract]2022 Oct:111:109107. PMID: 35932616 -
Sci Rep
Enhancement of melanoma aggressiveness via p38-MAPK, HIF-1α pathways, and metabolic reprogramming induced by Candida albicans. [Abstract]2025 Nov 17;15(1):40227. PMID: 41249785 -
Chem Biol Drug Des
Piceatannol selectively inhibited the JNK3 enzyme and augmented apoptosis through inhibition of Bcl-2/Cyt-c/caspase-dependent pathways in the oxygen-glucose deprived SHSY-5Y cell lines: In silico and in vitro study. [Abstract]2024 Feb;103(2):e14458. PMID: 38383061 -
Naunyn Schmiedebergs Arch Pharmacol
Piceatannol improved cerebral blood flow and attenuated JNK3 and mitochondrial apoptotic pathway in a global ischemic model to produce neuroprotection. [Abstract]2024 Jan;397(1):479-496. PMID: 37470802 -
Mol Immunol
IL-4 plays an essential role in DnaJ-ΔA146Ply-mediated immunoprotection against Streptococcus pneumoniae in mice. [Abstract]2022 Mar;143:105-113. PMID: 35114487 -
Mycopathologia
MiR-146a Negatively Regulates Aspergillus fumigatus-Induced TNF-α and IL-6 Secretion in THP-1 Macrophages. [Abstract]2021 Jun;186(3):341-354. PMID: 34089172 -
Cell Physiol Biochem
2016;38(6):2300-10. PMID: 27197738 -
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溶剤 & 溶解度
DMSO : 97.47 mg/mL (399.07 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : < 0.1 mg/mL (insoluble)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (10.24 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (10.24 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
純度とドキュメンテーション
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データシート (278 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Lu-Yuan Peng,et al. Protective Effect of Piceatannol Against Acute Lung Injury Through Protecting the Integrity of Air-Blood Barrier and Modulating the TLR4/NF-κB Signaling Pathway Activation. Front Pharmacol. 2020 Jan 22;10:1613. [Content Brief]
[2]. Jonathan Kershaw, et al. The Therapeutic Potential of Piceatannol, a Natural Stilbene, in Metabolic Diseases: A Review. J Med Food. 2017 May;20(5):427-438. [Content Brief]
[3]. Andrea Rinaldi, et al. In vitro efficacy of tyrosine kinase inhibitors: SYK and BCR-ABL inhibitors in lymphomas.Hematol Oncol. 2011 Sep;29(3):164-6. [Content Brief]
[4]. Kamila Siedlecka-Kroplewska, et al. Induction of autophagy, apoptosis and aquisition of resistance in response to piceatannol toxicity in MOLT-4 human leukemia cells. Toxicol In Vitro. 2019 Sep;59:12-25. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.0943 mL | 20.4717 mL | 40.9433 mL | 102.3583 mL |
| 5 mM | 0.8189 mL | 4.0943 mL | 8.1887 mL | 20.4717 mL | |
| 10 mM | 0.4094 mL | 2.0472 mL | 4.0943 mL | 10.2358 mL | |
| 15 mM | 0.2730 mL | 1.3648 mL | 2.7296 mL | 6.8239 mL | |
| 20 mM | 0.2047 mL | 1.0236 mL | 2.0472 mL | 5.1179 mL | |
| 25 mM | 0.1638 mL | 0.8189 mL | 1.6377 mL | 4.0943 mL | |
| 30 mM | 0.1365 mL | 0.6824 mL | 1.3648 mL | 3.4119 mL | |
| 40 mM | 0.1024 mL | 0.5118 mL | 1.0236 mL | 2.5590 mL | |
| 50 mM | 0.0819 mL | 0.4094 mL | 0.8189 mL | 2.0472 mL | |
| 60 mM | 0.0682 mL | 0.3412 mL | 0.6824 mL | 1.7060 mL | |
| 80 mM | 0.0512 mL | 0.2559 mL | 0.5118 mL | 1.2795 mL | |
| 100 mM | 0.0409 mL | 0.2047 mL | 0.4094 mL | 1.0236 mL |