Reverse Transcriptase
Reverse transcriptases (RTs) are enzyme used to generate complementary DNA (cDNA) from an RNA template, a process termed reverse transcription. Reverse transcriptases (RTs) use an RNA template and a short primer complementary to the 3' end of the RNA to direct the synthesis of the first strand cDNA.
Nucleoside reverse transcriptase inhibitors (NRTIs) block reverse transcriptase (an HIV enzyme). Non-nucleoside reverse transcriptase inhibitors (NNRTIs) bind to and block HIV reverse transcriptase. HIV uses reverse transcriptase to convert its RNA into DNA (reverse transcription). Blocking reverse transcriptase and reverse transcription prevents HIV from replicating.
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Reverse Transcriptase 関連製品 (263)
関連製品 (263)
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Inophyllum B
0 Images製品番号: HY-142074CAS 番号: 41135-06-2別名: (+)-Inophyllum BInophyllum B ((+)-Inophyllum B) is a potent HIV Reverse Transcriptase inhibitor with an IC50 value of 38 nM. Inophyllum B inhibits HIV-1 (IC50=1.4 μM) in vitro cell culture. Inophyllum B can be isolated from the acetone extract of the giant African snail, Achatina fulica.
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NNRT-IN-4
0 Images製品番号: HY-162720NNRT-IN-4 (Compound 10p) is an inhibitor for non-nucleoside reverse transcriptase (NNRT) with an IC50 of 0.713 µM for HIV-1 RT. NNRT-IN-4 exhibits antiviral efficacy, inhibits HIV-1 wildtype and mutant strains with EC50 of 6-63 nM. NNRT-IN-4 exhibits a slight inhibitory activities against hERG (IC50=25.9 µM) and CYP enzymes (IC50>50 µM). NNRT-IN-4 exhibits good tolerability and safety in mice (2 g/kg).
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Nevirapine-d4
0 Images製品番号: HY-10570SCAS 番号: 1051418-95-1Nevirapine-d4 is deuterium labeled Nevirapine. Nevirapine is a non-nucleoside inhibitor of HIV-1 reverse transcriptase used to treat and prevent HIV/AIDS; with a Ki of 270 μM.
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ALizarin complexone dihydrate
0 Images製品番号: HY-W320523CAS 番号: 455303-00-1ALizarin complexone dihydrate is the dehydrate of Alizarin complexone (HY-121075). Alizarin complexone is a calcium-binding fluorescent dye. Alizarin complexone stains mineralized areas of bone by binding to calcium crystals. Alizarin complexone inhibits the reverse transcriptase activity of RAV-2, HIV-1, and RSV with IC50 values of 3.8 μg/mL, 45 μg/mL, and 100 μg/mL, respectively. Alizarin complexone exhibits antiviral activity against HIV-1 and RSV. Alizarin complexone delays RSV-induced tumor induction in chickens.
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UC-84
0 Images製品番号: HY-105489CAS 番号: 135812-04-3別名: NSC-615985UC-84 (NSC-615985) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) with anti-HIV activity.
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Tivirapine
0 Images製品番号: HY-106918CAS 番号: 137332-54-8別名: R86183; TIBO R 86183
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(R)-Efavirenz
0 Images製品番号: HY-10572ACAS 番号: 154801-74-8別名: (R)-DMP 266; (R)-EFV; (R)-L-743726(R)-Efavirenz ((R)-DMP 266) is a non-nucleoside reverse transcriptase inhibitor that acts by non-competitive inhibition of the viral enzyme. (R)-Efavirenz can be metabolized by CYP2B6 to 8-hydroxyefavirenz in a highly stereoselective manner. (R)-Efavirenz is promising to be a useful probe for the CYP2B6 active site and catalytic mechanisms.
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4'-Ethynyl-2'-deoxyadenosine
0 Images製品番号: HY-125810CAS 番号: 306305-07-74'-Ethynyl-2'-deoxyadenosine (4'-E-dA), a nucleoside reverse transcriptase (RT) inhibitor, is an antiretroviral agent which is potent against drug-resistant HIV variants, with an EC50 of 98 nM in MT-4 cells for anti-HIV-1 activity. 4'-Ethynyl-2'-deoxyadenosine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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Adefovir-d4
0 Images別名: GS-0393-d4; PMEA-d4Adefovir-d4 is the deuterium labeled Adefovir. Adefovir (GS-0393) is an adenosine monophosphate analog antiviral agent that after intracellular conversion to Adefovir diphosphate inhibits HBV DNA polymerase. Adefovir has an IC50 of 0.7 μM against HBV in the HepG2.2.15 cell line. Adefovir has good antiviral activity against several viruses, including HBV and herpesviruses.
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UC-38
0 Images製品番号: HY-105491CAS 番号: 135812-34-9別名: NSC-629243UC-38 (NSC-629243) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) with anti-HIV activity.
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NNRT-IN-8
0 Images製品番号: HY-172996NNRT-IN-8 (compound 9K) is a potent non-nucleoside reverse transcriptase inhibitor with EC50 values of 0.0014, 0.0041, 0.0077 µM for WT HIV-1, K103N, E138K, respectively.
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K-5a2
0 Images製品番号: HY-173427CAS 番号: 1810730-10-9K-5a2 is the non-isotopic form of ZK-316 (HY-173427S). ZK-316 is a potent and broad-spectrum NNRTI inhibitor with an EC50 value ranging from 0.99 to 75.1 nM. ZK-316 can be used in the study of HIV.
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R82913
0 Images製品番号: HY-106872CAS 番号: 126347-69-1別名: 9-Cl-TIBOR82913 (9-Cl-TIBO) is a potent and high selective inhibitor of HIV-1 reverse transcriptase with antiviral activity on both an RNA template (negative strand synthesis) and a DNA template (positive strand synthesis). R82913 inhibits the replication of different strains of HIV-I in CEM cells with a median IC50 value of of 0.15 μM.
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Atevirdine mesylate
0 Images製品番号: HY-105097CAS 番号: 138540-32-6別名: U 87201E mesylateAtevirdine (U 87201E) mesylate is a nonnucleoside reverse transcriptase (NNRT) inhibitor. Atevirdine mesylate can inhibit human immunodeficiency virus type 1 (HIV-1) with an IC50 of 0.06-1.6 μM. Atevirdine mesylate shows highly synergistic effects against Zidovudine/Didanosine-resistant clinical isolates of HIV-1 companied with Zidovudine (HY-17413)/Didanosine (Hy-B0249). Atevirdine mesylate can be used for the research of AIDS.
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Dexelvucitabine
0 Images別名: Reverset; d-d4FCDexelvucitabine (Reverset; d-d4FC), a Cytidine (HY-B0158) analog, is an orally active nucleoside reverse transcriptase inhibitor. Dexelvucitabine is a powerful agent against HIV-1-resistant viruses containing a thymidine analog and/or M184V mutation in the viral polymerase. Dexelvucitabine is a 2′-Deoxycytidine antiretroviral agent.
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Thiazolobenzimidazole
0 Images製品番号: HY-19162CAS 番号: 138226-12-7別名: NSC-625487Thiazolobenzimidazole (NSC-625487) is a highly potent nonnucleoside HIV-1 reverse transcriptase inhibitor. Thiazolobenzimidazole inhibits HIV-induced cell killing and viral replication in a variety of human cell lines.
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Didanosine-d2
0 Images製品番号: HY-B0249SDidanosine-d2 is the deuterium labeled Didanosine. Didanosine (Videx) is a reverse transcriptase inhibitor with an IC50 of 0.49 μM.
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(+)-Carbovir triphosphate
0 Images製品番号: HY-126082CAS 番号: 144606-93-9(+)-Carbovir triphosphate is an enantiomer of Carbovir triphosphate (HY-131607). (+)-Carbovir triphosphate is an inhibitor and substrate of HIV reverse transcriptase.
