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Cat. No.: HY-125810

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4'-Ethynyl-2'-deoxyadenosine

4'-Ethynyl-2'-deoxyadenosine (4'-E-dA), a nucleoside reverse transcriptase (RT) inhibitor, is an antiretroviral agent which is potent against drug-resistant HIV variants, with an EC₅₀ of 98 nM in MT-4 cells for anti-HIV-1 activity. 4'-Ethynyl-2'-deoxyadenosine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

For research use only. We do not sell to patients.

CAS No.: 306305-07-7
Formula: C₁₂H₁₃N₅O₃
Molecular Weight:275.26

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

4'-Ethynyl-2'-deoxyadenosine Chemical Structure

CAS No.: 306305-07-7

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Biological Activity
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- Cellular Effect
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Biological Activity

Description

4'-Ethynyl-2'-deoxyadenosine (4'-E-dA), a nucleoside reverse transcriptase (RT) inhibitor, is an antiretroviral agent which is potent against drug-resistant HIV variants, with an EC₅₀ of 98 nM in MT-4 cells for anti-HIV-1 activity^[1]. 4'-Ethynyl-2'-deoxyadenosine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC₅₀ & Target

HIV-1

All HIV Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HeLa	EC₅₀	0.0068 μM Compound: 72	Tested in vitro against HIV-1 104pre from HeLa-CD4-LT4-beta gal-cells using MAGI assay Tested in vitro against HIV-1 104pre from HeLa-CD4-LT4-beta gal-cells using MAGI assay	[PMID: 11087576]
MT4	CC₅₀	11.7 μM Compound: 72	Tested in vitro against MT-4 cells using MTT assay Tested in vitro against MT-4 cells using MTT assay	[PMID: 11087576]
MT4	CC₅₀	16 μM Compound: 45	Cytotoxicity against human MT4 cells after 4 days by MTT assay Cytotoxicity against human MT4 cells after 4 days by MTT assay	[PMID: 23795238]
MT4	EC₅₀	0.0098 μM Compound: 45	Antiviral activity against HIV-1 infected in human MT-4 cells assessed as inhibition of viral-induced cytopathogenicity after 4 days by MTT assay Antiviral activity against HIV-1 infected in human MT-4 cells assessed as inhibition of viral-induced cytopathogenicity after 4 days by MTT assay	[PMID: 23795238]
MT4	EC₅₀	0.012 μM Compound: 72	Tested in vitro against HIV-1 LAI from MT-4 cells using MTT assay Tested in vitro against HIV-1 LAI from MT-4 cells using MTT assay	[PMID: 11087576]

Chemical Information

CAS No. 306305-07-7
Molecular Weight 275.26
Formula C₁₂H₁₃N₅O₃
SMILES

OC[C@]1(C#C)[C@H](C[C@H](N2C=NC3=C(N=CN=C32)N)O1)O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Ohrui H, et al. 4'-C-substituted-2'-deoxynucleosides: a family of antiretroviral agents which are potent against drug-resistant HIV variants. Curr Drug Targets Infect Disord. 2001 May;1(1):1-10. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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Purity & Documentation
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4'-Ethynyl-2'-deoxyadenosine

All HIV Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

4'-Ethynyl-2'-deoxyadenosine Related Classifications

HY-125810 Related Classifications