(R)-Efavirenz
(R)-Efavirenz ((R)-DMP 266) is a non-nucleoside reverse transcriptase inhibitor that acts by non-competitive inhibition of the viral enzyme. (R)-Efavirenz can be metabolized by CYP2B6 to 8-hydroxyefavirenz in a highly stereoselective manner. (R)-Efavirenz is promising to be a useful probe for the CYP2B6 active site and catalytic mechanisms.
For research use only. We do not sell to patients.
- CAS No.: 154801-74-8
- Formula: C14H9ClF3NO2
- Molecular Weight:315.67
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Chemical Information
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CAS No. 154801-74-8
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Molecular Weight 315.67
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Formula C14H9ClF3NO2
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SMILES
FC(F)(F)[C@]1(C2=CC(Cl)=CC=C2NC(O1)=O)C#CC3CC3
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Synonyms
(R)-DMP 266; (R)-EFV; (R)-L-743726
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Maggiolo F. Efavirenz. Expert Opin Pharmacother. 2007 Jun;8(8):1137-45. [Content Brief]
[2]. Wang PF, et al. Efavirenz Metabolism: Influence of Polymorphic CYP2B6 Variants and Stereochemistry. Drug Metab Dispos. 2019 Oct;47(10):1195-1205. doi: 10.1124/dmd.119.086348. Epub 2019 Jul 19. Erratum in: Drug Metab Dispos. 2019 Oct;47(10):1231. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)