2. Anti-infection
  3. Reverse Transcriptase HIV
  4. Thiazolobenzimidazole

Thiazolobenzimidazole (NSC-625487) is a highly potent nonnucleoside HIV-1 reverse transcriptase inhibitor. Thiazolobenzimidazole inhibits HIV-induced cell killing and viral replication in a variety of human cell lines.

For research use only. We do not sell to patients.

Thiazolobenzimidazole

Thiazolobenzimidazole Chemical Structure

CAS No. : 138226-12-7

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Thiazolobenzimidazole Related Antibodies

Top Publications Citing Use of Products

View All HIV Isoform Specific Products:

View All Isoforms
HIV HIV-1 HIV-2

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Thiazolobenzimidazole (NSC-625487) is a highly potent nonnucleoside HIV-1 reverse transcriptase inhibitor. Thiazolobenzimidazole inhibits HIV-induced cell killing and viral replication in a variety of human cell lines[1].

IC50 & Target[1]

HIV-1

 

Cellular Effect
Cell Line Type Value Description References
CCRF-CEM CC50
50 μM
Compound: TBZ
Cytotoxicity against CEM cells
Cytotoxicity against CEM cells
[PMID: 17178227]
CCRF-CEM CC50
50 μM
Compound: TBZ-1
Cytotoxicity against mock-infected CEM cells assessed as reduction of cell viability
Cytotoxicity against mock-infected CEM cells assessed as reduction of cell viability
[PMID: 17349793]
CCRF-CEM CC50
50 μM
Compound: TBZ-1
Cytotoxicity against human CEM cells by MTT assay
Cytotoxicity against human CEM cells by MTT assay
[PMID: 18242784]
CCRF-CEM EC50
1.1 μM
Compound: TBZ
Antiviral activity against HIV1 3B in CEM cells assessed as inhibition of virus-induced syncytium formation after 4 days
Antiviral activity against HIV1 3B in CEM cells assessed as inhibition of virus-induced syncytium formation after 4 days
[PMID: 17178227]
CCRF-CEM EC50
1.1 μM
Compound: TBZ-1
Antiviral activity against HIV1 3B-induced cytopathic effect in CEM cells assessed as inhibition of virus-induced syncytium formation
Antiviral activity against HIV1 3B-induced cytopathic effect in CEM cells assessed as inhibition of virus-induced syncytium formation
[PMID: 17349793]
CCRF-CEM EC50
1.1 μM
Compound: TBZ-1
Antiviral activity against HIV1 3B replication in human CEM cells assessed as inhibition of virus-induced cytopathic effect after 5 days by tetrazolium-based colorimetric assay
Antiviral activity against HIV1 3B replication in human CEM cells assessed as inhibition of virus-induced cytopathic effect after 5 days by tetrazolium-based colorimetric assay
[PMID: 18242784]
CCRF-CEM EC50
1.73 μM
Compound: TBZ
Concentration required to protect CEM cells against Mutant E138K Strain
Concentration required to protect CEM cells against Mutant E138K Strain
[PMID: 15857150]
CCRF-CEM EC50
13.8 μM
Compound: TBZ
Concentration required to protect CEM cells against Mutant Y181C Strain
Concentration required to protect CEM cells against Mutant Y181C Strain
[PMID: 15857150]
CCRF-CEM EC50
15.6 μM
Compound: TBZ
Concentration required to protect CEM cells against Mutant K103N Strain
Concentration required to protect CEM cells against Mutant K103N Strain
[PMID: 15857150]
CCRF-CEM EC50
3.12 μM
Compound: TBZ
Concentration required to protect CEM cells against Mutant L100I Strain
Concentration required to protect CEM cells against Mutant L100I Strain
[PMID: 15857150]
CCRF-CEM EC50
4.16 μM
Compound: TBZ
Concentration required to protect CEM cells against Mutant Y188H Strain
Concentration required to protect CEM cells against Mutant Y188H Strain
[PMID: 15857150]
CEM-SS EC50
0.52 mM
Compound: TZB
In vitro 50% cellular protection of CEM-SS cells from HIV-1 induced cytopathicity.
In vitro 50% cellular protection of CEM-SS cells from HIV-1 induced cytopathicity.
[PMID: 9435891]
MT4 CC50
19.2 μM
Compound: TBZ
Cytotoxicity against MT4 cells
Cytotoxicity against MT4 cells
[PMID: 17178227]
MT4 CC50
19.2 μM
Compound: TBZ-1
Cytotoxicity against mock-infected MT4 cells assessed as reduction of cell viability
Cytotoxicity against mock-infected MT4 cells assessed as reduction of cell viability
[PMID: 17349793]
MT4 CC50
19.2 μM
Compound: TBZ-1
Cytotoxicity against human MT4 cells by MTT assay
Cytotoxicity against human MT4 cells by MTT assay
[PMID: 18242784]
MT4 CC50
19.2 μM
Compound: TBZ1
Cytotoxicity to reduce MT-4 cell viability by 50%
Cytotoxicity to reduce MT-4 cell viability by 50%
[PMID: 11425562]
MT4 CC50
50 μM
Compound: TBZ
Cytotoxic concentration required to reduce MT-4 cell viability
Cytotoxic concentration required to reduce MT-4 cell viability
[PMID: 15857150]
MT4 EC50
0.35 μM
Compound: TBZ
Antiviral activity against HIV1 3B in MT4 cells assessed as inhibition of virus-induced syncytium formation after 5 days
Antiviral activity against HIV1 3B in MT4 cells assessed as inhibition of virus-induced syncytium formation after 5 days
[PMID: 17178227]
MT4 EC50
0.35 μM
Compound: TBZ-1
Antiviral activity against HIV1 3B-induced cytopathic effect in MT4 cells assessed as inhibition of virus-induced syncytium formation
Antiviral activity against HIV1 3B-induced cytopathic effect in MT4 cells assessed as inhibition of virus-induced syncytium formation
[PMID: 17349793]
MT4 EC50
0.35 μM
Compound: TBZ-1
Antiviral activity against HIV1 3B replication in human MT4 cells assessed as inhibition of virus-induced cytopathic effect after 5 days by tetrazolium-based colorimetric assay
Antiviral activity against HIV1 3B replication in human MT4 cells assessed as inhibition of virus-induced cytopathic effect after 5 days by tetrazolium-based colorimetric assay
[PMID: 18242784]
MT4 EC50
0.352 μM
Compound: TBZ1
Anti-HIV activity to reduce HIV-1-induced cytopathic effect by 50% in MT-4 cells against HIV-1 IIIB
Anti-HIV activity to reduce HIV-1-induced cytopathic effect by 50% in MT-4 cells against HIV-1 IIIB
[PMID: 11425562]
MT4 EC50
1.1 μM
Compound: TBZ
Concentration required to reduce HIV-1-induced cytopathic effect in MT-4 cells
Concentration required to reduce HIV-1-induced cytopathic effect in MT-4 cells
[PMID: 15857150]
MT4 EC50
1.39 μM
Compound: TBZ
Compound was tested for inhibition of the cytopathic effects of HIV-1 (IIIB) in MT-4 cells
Compound was tested for inhibition of the cytopathic effects of HIV-1 (IIIB) in MT-4 cells
[PMID: 15857150]
MT4 EC50
1100 nM
Compound: 81; NSC625487
Antiviral activity against HIV1 infected in human MT4 cells assessed as protection against HIV-1 induced cytopathicity by MTT assay
Antiviral activity against HIV1 infected in human MT4 cells assessed as protection against HIV-1 induced cytopathicity by MTT assay
[PMID: 26509831]
MT4 IC50
14.6 μM
Compound: TBZ1
Evaluated for the inhibition of replication of HIV-1 IIIB or HIV-2 (ROD) in MT-4 cells by using [3H]-dGTP as the radiolabeled substrate
Evaluated for the inhibition of replication of HIV-1 IIIB or HIV-2 (ROD) in MT-4 cells by using [3H]-dGTP as the radiolabeled substrate
[PMID: 11425562]
Molecular Weight

288.32

Formula

C15H10F2N2S
CAS No.
SMILES

FC1=C(C2SCC3=NC4=CC=CC=C4N32)C(F)=CC=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Thiazolobenzimidazole Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Thiazolobenzimidazole138226-12-7NSC-625487NSC625487NSC 625487Reverse TranscriptaseHIVHuman immunodeficiency virusHIV-1 reverse transcriptase inhibitorInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Thiazolobenzimidazole
Cat. No.:
HY-19162
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.