2. Anti-infection
  3. Reverse Transcriptase HIV
  4. Tivirapine

Tivirapine (R86183) is a nonnucleoside HIV-1 RT inhibitor against HIV-1-induced cytopathic effects with an EC50 value of 4 nM. Tivirapine inhibits the Yl8lC mutant of HIV-1 RT.

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Tivirapine

Tivirapine Chemical Structure

CAS No. : 137332-54-8

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Tivirapine Related Antibodies

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Description

Tivirapine (R86183) is a nonnucleoside HIV-1 RT inhibitor against HIV-1-induced cytopathic effects with an EC50 value of 4 nM. Tivirapine inhibits the Yl8lC mutant of HIV-1 RT[1].

Cellular Effect
Cell Line Type Value Description References
C8166 CC50
50 μM
Compound: 8-CITIBO
Cytotoxicity against C8166 cells by MTT assay
Cytotoxicity against C8166 cells by MTT assay
[PMID: 16279773]
C8166 EC50
0.03 μM
Compound: 2 (8-CITIBO)
Concentration which produces a 50% survival of HIV-1 infected cells relative to uninfected control C8166 cells
Concentration which produces a 50% survival of HIV-1 infected cells relative to uninfected control C8166 cells
[PMID: 11462972]
C8166 EC50
0.03 μM
Compound: 8-CITIBO
Inhibition of HIV1-3B replication in C8166 cells
Inhibition of HIV1-3B replication in C8166 cells
[PMID: 16279773]
C8166 EC50
0.03 μM
Compound: 8-ClTIBO
Antiviral activity against HIV1 3B infected human C8166 cells assessed as inhibition of syncytia formation by p24 antigen based assay
Antiviral activity against HIV1 3B infected human C8166 cells assessed as inhibition of syncytia formation by p24 antigen based assay
[PMID: 19170521]
C8166 IC50
50 μM
Compound: 2 (8-CITIBO)
Concentration which results in 50% survival of uninfected untreated control C8166 cells (cytotoxicity of the compound)
Concentration which results in 50% survival of uninfected untreated control C8166 cells (cytotoxicity of the compound)
[PMID: 11462972]
MT2 EC50
14 nM
Compound: 2, 8-Cl-TIBO
Antiviral activity against HIV-1 infected un MT2 cells assessed as virus-induced cytopathicity after 5 days by MTT assay
Antiviral activity against HIV-1 infected un MT2 cells assessed as virus-induced cytopathicity after 5 days by MTT assay
[PMID: 23380374]
MT2 IC50
> 100 nM
Compound: 2, 8-Cl-TIBO
Cytotoxicity against human MT2 cells after 5 days by MTT assay
Cytotoxicity against human MT2 cells after 5 days by MTT assay
[PMID: 23380374]
MT4 EC50
0.0043 μM
Compound: 9, R86183
Antiviral activity against Human immunodeficiency virus 1 infected in human MT4 cells
Antiviral activity against Human immunodeficiency virus 1 infected in human MT4 cells
[PMID: 19632850]
MT4 EC50
4.6 nM
Compound: 3
Effective concentration of the compound to inhibit HIV-1 replication in HIV-infected MT-4 cells
Effective concentration of the compound to inhibit HIV-1 replication in HIV-infected MT-4 cells
[PMID: 15771411]
MT4 IC50
0.0043 μM
Compound: 6a
Concentration required for 50% protection of MT-4 cells against the cytopathic effect of HIV-1
Concentration required for 50% protection of MT-4 cells against the cytopathic effect of HIV-1
[PMID: 7877144]
Molecular Weight

321.87

Formula

C16H20ClN3S
CAS No.
SMILES

ClC(C1=C2N3C[C@@H](N(C1)C/C=C(C)\C)C)=CC=C2NC3=S
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Tivirapine Related Classifications

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tivirapine137332-54-8R86183 TIBO R 86183R 86183R-86183TIBO R86183TIBO R 86183TIBO R-86183Reverse TranscriptaseHIVHuman immunodeficiency virusHIV-1 RTcytopathic effectYl8lC mutantInhibitorinhibitorinhibit

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