2. Anti-infection Cell Cycle/DNA Damage
  3. Reverse Transcriptase HIV DNA/RNA Synthesis
  4. R82913

R82913 (9-Cl-TIBO) is a potent and high selective inhibitor of HIV-1 reverse transcriptase with antiviral activity on both an RNA template (negative strand synthesis) and a DNA template (positive strand synthesis). R82913 inhibits the replication of different strains of HIV-I in CEM cells with a median IC50 value of of 0.15 μM.

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R82913

R82913 Chemical Structure

CAS No. : 126347-69-1

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Description

R82913 (9-Cl-TIBO) is a potent and high selective inhibitor of HIV-1 reverse transcriptase with antiviral activity on both an RNA template (negative strand synthesis) and a DNA template (positive strand synthesis). R82913 inhibits the replication of different strains of HIV-I in CEM cells with a median IC50 value of of 0.15 μM[1][2].

Cellular Effect
Cell Line Type Value Description References
C8166 CC50
34 μM
Compound: TIBO R-82913
Cytotoxic activity was evaluated in CD4+ lymphoblastoid cell line
Cytotoxic activity was evaluated in CD4+ lymphoblastoid cell line
10.1016/0960-894X(95)00257-T
C8166 EC50
0.002 μM
Compound: 1c (R 82913)
Inhibitory activity against HIV-111B in C8166 cells
Inhibitory activity against HIV-111B in C8166 cells
10.1016/0960-894X(95)00203-6
C8166 EC50
0.002 μM
Compound: R-82913
Tested against HIV-1 111B for Inhibition of viral replication by determining reduction of syncytia formation and antigen gp120 in C8166 cells, estimated by ELISA
Tested against HIV-1 111B for Inhibition of viral replication by determining reduction of syncytia formation and antigen gp120 in C8166 cells, estimated by ELISA
10.1016/S0960-894X(97)00022-X
C8166 IC50
0.0015 μM
Compound: TIBO R-82913
Antiviral activity was evaluated by inhibition of HIV-1 replication in CD4+ lymphoblastoid cell line infected with HIV/IIIB strain
Antiviral activity was evaluated by inhibition of HIV-1 replication in CD4+ lymphoblastoid cell line infected with HIV/IIIB strain
10.1016/0960-894X(95)00257-T
CEM-SS CC50
35 μM
Compound: R-82913
Tested for the cytotoxicity against CEM-SS cells (determined by the inhibition of [3H]-thymidine uptake)
Tested for the cytotoxicity against CEM-SS cells (determined by the inhibition of [3H]-thymidine uptake)
10.1016/S0960-894X(01)81224-5
CEM-SS CC50
> 10000 nM
Compound: TIBO R-82913
Cytotoxicity against wild type HIV-1-IIIB strain infected CEMSS cells.
Cytotoxicity against wild type HIV-1-IIIB strain infected CEMSS cells.
[PMID: 7473595]
CEM-SS IC50
0.055 μM
Compound: R-82913
Tested for the inhibition of HIV-1 in CEM-SS cells measured using Syncytial assay
Tested for the inhibition of HIV-1 in CEM-SS cells measured using Syncytial assay
10.1016/S0960-894X(01)81224-5
CEM-SS IC50
> 10000 nM
Compound: TIBO R-82913
Inhibition of wild type HIV-1-IIIB strain replication in CEM-SS cells
Inhibition of wild type HIV-1-IIIB strain replication in CEM-SS cells
[PMID: 7473595]
MOLT-4 IC50
0.19 μM
Compound: TIBO R-82913
Anti-HIV activity against HIV-1 in Molt-4 cells using 7-day infective assay
Anti-HIV activity against HIV-1 in Molt-4 cells using 7-day infective assay
[PMID: 7506311]
MOLT-4 IC50
19 μM
Compound: TIBO R-82913
Tested for cytotoxicity in Molt-4 cells by XTT assay
Tested for cytotoxicity in Molt-4 cells by XTT assay
[PMID: 7506311]
MT4 EC50
33 nM
Compound: 2
Effective concentration of the compound to inhibit HIV-1 replication in HIV-infected MT-4 cells
Effective concentration of the compound to inhibit HIV-1 replication in HIV-infected MT-4 cells
[PMID: 15771411]
MT4 IC50
0.034 μM
Compound: 1a
Concentration required for 50% protection of MT-4 cells against the cytopathic effect of HIV-1
Concentration required for 50% protection of MT-4 cells against the cytopathic effect of HIV-1
[PMID: 7877144]
MT4 IC50
0.039 μM
Compound: 8b
Ability to block replication of HIV-1 virus in mock infected MT-4 cells
Ability to block replication of HIV-1 virus in mock infected MT-4 cells
[PMID: 1956037]
MT4 IC50
0.042 μM
Compound: 2
Compound was tested for its anti HIV-1 activity in MT-4 cells.
Compound was tested for its anti HIV-1 activity in MT-4 cells.
10.1016/S0960-894X(01)80460-1
Molecular Weight

321.87

Formula

C16H20ClN3S
CAS No.
SMILES

S=C1N2C3=C(C=C(C=C3N1)Cl)CN([C@H](C2)C)C/C=C(C)\C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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R82913 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

R82913126347-69-19-Cl-TIBOR 82913R-82913Reverse TranscriptaseHIVDNA/RNA SynthesisHuman immunodeficiency virusHIV-1 reverse transcriptaseantiviral activityRNA templateDNA templateCEM cellsInhibitorinhibitorinhibit

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