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製品番号: HY-113628

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ABT-080

Name: ABT-080
Brand: MedChemExpress
SKU: HY-113628
Price: 79.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(別名: VML-530)

カスタマーレビュー

Based on 1 Customer Validation

ABT-080 is an orally active inhibitor of leukotriene biosynthesis that targets 5-lipoxygenase-activating protein (FLAP). ABT-080 inhibits leukotriene production in intact human neutrophils, mouse peritoneal macrophages and human whole blood, with IC₅₀ values of 20 nM, 0.16 nM and 13 μM, respectively. ABT-080 blocks the leukotriene pathway leading to the synthesis of LTB4 and LTC4, but does not block PGH2 biosynthesis. ABT-080 inhibits leukotriene biosynthesis and bronchoconstriction in mouse models. ABT-080 is used in research related to asthma, pleurisy and allergy.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

純度 : 98.42%
CAS 番号: 189498-57-5
分子式: C₃₇H₃₁N₂NaO₄
分子量:590.64

保管条件:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

ABT-080 構造式

CAS 番号: 189498-57-5

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
- 体内実験
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

IC₅₀ & Target

LTB4

20 nM (IC₅₀, intact human neutrophils)

LTB4

13 μM (IC₅₀, human whole blood)

LTC4

0.16 nM (IC₅₀, mouse peritoneal macrophages)

体外実験

Lipid Inflammatory MediatorsInnate Immunity

Lipid Inflammatory Mediators

Innate Immunity

ABT-080 free base potently inhibits the production of LTB₄ in intact human neutrophils stimulated by calcium ionophores, with an IC₅₀ of 20 nM. This inhibitory effect shows weak reversibility, and binding to serum albumin significantly reduces its inhibitory activity^[1].
ABT-080 free base inhibits LTB4 production in human whole blood stimulated by calcium ionophore, with an IC₅₀ of 13000 nM^[1].

Innate Immunity

The free base form of ABT-080 (300 μM) does not inhibit the 5-lipoxygenase-catalyzed oxidation of arachidonic acid in the supernatant of sonicated RBL-2H3 cells^[1].
ABT-080 free base exhibits inhibitory activity against LTC₄ production in zymosan-stimulated mouse peritoneal macrophages (IC₅₀ = 0.16 nM), with a 9000-fold higher selectivity for LTC₄ over PGE₂ (PGE₂ IC₅₀ = 1500 nM).

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

InflammasomeOthersInnate Immunity

Inflammasome

The free base of ABT-080 (3.0 mg/kg; p.o.) inhibits leukotriene biosynthesis in a rat pleurisy model, with an ED₅₀ of 3.0 mg/kg^[1].

Others

ABT-080 (1.0-10 mg/kg; p.o.) free base inhibits the production of LTB₄ (ED₅₀ = 2.5 mg/kg) and LTE₄ (ED₅₀ = 1.0 mg/kg) in a rat peritoneal passive anaphylaxis model, and the 70% inhibitory effect on LTE₄ persists for 8 h at a dose of 10 mg/kg^[1].
The free base of ABT-080 (0.4 mg/kg; p.o.) inhibits antigen-induced bronchoconstriction in actively sensitized guinea pigs, with an ED₅₀ of 0.4 mg/kg^[1].

Innate Immunity

The free base form of ABT-080 (3.3-3.5 mg/kg; p.o.; twice daily; for 4 consecutive days) inhibits leukotriene production (ED₅₀ = 3.3 mg/kg) and eosinophil infiltration (ED₅₀ = 3.5 mg/kg) in a Brown Norway rat model of pulmonary inflammation, with an administration regimen of twice daily oral dosing for 4 consecutive days^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Rats were dosed with
experimental compounds in 0.2% HPMC 1 h before the
intrapleural injection of the calcium ionophore A-23187. The
rats were lightly anesthetized with penthrane and injected
intrapleurally with 0.5 mL of 2% ethanol in injectable saline
containing 20 μg of A-23187 (HY-N6687).^[1]
Dosage:

3.0 mg/kg (ED₅₀)
Administration:

p.o.; single dose (1 hour pre-challenge)
Result:

Inhibited leukotriene biosynthesis with an ED₅₀ of 3.0 mg/kg.

Animal Model:

At Peritoneal Anaphylaxis Model. Rats were pas-sively sensitized to bovine serum albumin, and 3 h later theywere challenged in the peritoneal cavity with antigen^[1]
Dosage:

2.5 mg/kg (LTB4 ED₅₀); 1.0 mg/kg (LTE4 ED₅₀); 10 mg/kg (duration-of-action)
Administration:

p.o.; single dose
Result:

Inhibited LTB4 production with an ED₅₀ of 2.5 mg/kg.
Inhibited LTE4 production with an ED₅₀ of 1.0 mg/kg.
Inhibited LTE4 production by 70% for up to 8 hours at a single oral dose of 10 mg/kg.

Animal Model:

Brown Norway rats wereBis(heteroarylmethoxyphenyl)alkylcarboxylic Acids Journal of Medicinal Chemistry, 2000, Vol. 43, No. 17 3333
orally dosed with inhibitors in 0.2% methylcellulose and theninjected in the central tail vein with Sephadex G-200. For thenext 3 days, the rats were dosed either once or twice a daywith either inhibitor or the vehicle control, 0.2% methylcel-lulose.^[1]
Dosage:

3.3 mg/kg (leukotriene formation ED50); 3.5 mg/kg (eosinophil influx ED₅₀)
Administration:

p.o.; twice daily; 4 days
Result:

Inhibited leukotriene formation with an ED₅₀ of 3.3 mg/kg.
Inhibited eosinophil influx with an ED₅₀ of 3.5 mg/kg.

Animal Model:

Guinea pigs^[1]
Dosage:

0.4 mg/kg (ED₅₀)
Administration:

p.o.
Result:

Inhibited antigen-induced bronchoconstriction with an ED₅₀ of 0.4 mg/kg.

化学情報

CAS 番号 189498-57-5
性状 Solid
分子量 590.64
分子式 C₃₇H₃₁N₂NaO₄
Color Off-white to light yellow
SMILES

O=C(CCC(C)(C1=CC=C(C=C1)OCC2=NC3=CC=CC=C3C=C2)C4=CC=C(C=C4)OCC5=NC6=CC=CC=C6C=C5)O[Na]
別名

VML-530
輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (290 KB)
SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Kolasa T, et al. Symmetrical bis(heteroarylmethoxyphenyl)alkylcarboxylic acids as inhibitors of leukotriene biosynthesis. Journal of medicinal chemistry. 2000 Aug 24;43(17):3322-34. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

MOQ

Minimum order quantity

100 mg

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生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
- 体内実験
化学情報
純度とドキュメンテーション
参考文献

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ABT-080

生物活性

製品説明

IC₅₀ & Target

体外実験

体内実験

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

Bioz

Keywords

最近チェックした製品

ABT-080

生物活性

製品説明

IC50 & Target

体外実験

体内実験

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

ABT-080 関連分類

HY-113628 関連分類

Bioz

Keywords

最近チェックした製品

IC₅₀ & Target