country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

製品番号: HY-WAA0304

Copy Link Print Information

Agmatine

1 Cited Publications

カスタマーレビュー

Based on 1 publication(s) in Google Scholar

Agmatine is an orally active analgesic that can cross the blood-brain barrier. Agmatine targets the 5-HT_2A receptor, 5-HT₃ receptor, α₂-adrenergic receptor, and I1 imidazoline receptor. Agmatine produces dose-dependent analgesic effects in various pain models. Agmatine can be used in research related to visceral pain, neuropathic pain, and inflammatory pain.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 306-60-5
分子式: C₅H₁₄N₄
分子量:130.19

保管条件:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Agmatine 構造式

CAS 番号: 306-60-5

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

IC₅₀ & Target^[1]

5-HT_2A Receptor

5-HT₃ Receptor

α2-adrenergic receptor

5-HT Receptor アイソフォーム固有の製品をすべて表示 :

Adrenergic Receptor アイソフォーム固有の製品をすべて表示 :

体内実験

Agmatine (1-30 mg/kg; i.p.; 30 min pre-acetic acid, 0.5-6 hours pre-acetic acid; 10-300 mg/kg; p.o.; 60 min pre-acetic acid) produces dose-dependent, long-lasting antinociception against acetic acid-induced visceral pain in Mus musculus, with 26-fold greater potency via i.p. (ID₅₀ 5.6 mg/kg) than oral (ID₅₀ 147.3 mg/kg) administration, acting through nitrergic, opioid, α₂-adrenoceptor, imidazoline I₁, and serotonergic (5-HT_2A, 5-HT₃) pathways^[2].
Agmatine (10-100 mg/kg; i.p.; 30 min pre-glutamate) dose-dependently inhibits glutamate-induced paw nociception in mice with an ID₅₀ of 19.5 mg/kg (i.p.)^[2].
Agmatine (3-100 mg/kg; i.p.; 30 min pre-capsaicin) dose-dependently inhibits Capsaicin (HY-10448)-induced paw nociception in mice with an ID₅₀ of 43.7 mg/kg (i.p.)^[2].
Agmatine (1-100 mg/kg; i.p.; 30 min pre-formalin; 10 mg/kg; i.p.; 10 min pre-formalin; 10 mg/kg; i.p.; 5 min post-formalin) dose-dependently inhibits both neurogenic and inflammatory phases of formalin-induced paw nociception in mice, with greater potency against the inflammatory phase (ID₅₀ 5.6 mg/kg i.p.) than the neurogenic phase (ID₅₀ 13.7 mg/kg i.p.)^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Swiss mice (both sexes, 25-35 g)^[2]
Dosage:

1-30 mg/kg (i.p.); 10-300 mg/kg (p.o.)
Administration:

i.p. (30 min pre-acetic acid; 0.5, 1, 2, 4, or 6 hours pre-acetic acid); p.o. (60 min pre-acetic acid)
Result:

Produced dose-dependent inhibition of acetic acid-induced abdominal constrictions, with an ID₅₀ of 5.6 mg/kg (i.p.) and 147.3 mg/kg (p.o.), achieving maximum inhibitions of 83% and 57%, respectively.
Produced significant antinociception starting at 30 minutes post-administration with 10 mg/kg i.p., which persisted for up to 4 hours.
Had its antinociceptive effect completely reversed by pre-treatment with L-arginine (600 mg/kg i.p.), naloxone (1 mg/kg i.p.), yohimbine (0.15 mg/kg i.p.), ketanserin (0.3 mg/kg i.p.), ondansetron (0.5 mg/kg i.p.), or efaroxan (1 mg/kg i.p.), but not by D-arginine (600 mg/kg i.p.), pindolol (1 mg/kg i.p.), idazoxan (3 mg/kg i.p.), or neonatal capsaicin treatment.
Had its antinociceptive effect significantly reversed by pre-treatment with p-chlorophenylalanine methyl ester (100 mg/kg i.p. once daily for 4 days).

Animal Model:

Swiss mice (both sexes, 25-35 g)^[2]
Dosage:

10-100 mg/kg
Administration:

i.p. (30 min pre-glutamate)
Result:

Produced dose-dependent inhibition of glutamate-induced paw licking, with an ID₅₀ of 19.5 mg/kg and a maximum inhibition of 76%.

Animal Model:

Swiss mice (both sexes, 25-35 g)^[2]
Dosage:

3-100 mg/kg
Administration:

i.p. (30 min pre-capsaicin)
Result:

Produced dose-dependent inhibition of capsaicin-induced paw licking, with an ID₅₀ of 43.7 mg/kg and a maximum inhibition of 55%.

Animal Model:

Swiss mice (both sexes, 25-35 g)^[2]
Dosage:

1-100 mg/kg (30 min pre-formalin); 10 mg/kg (10 min pre-formalin); 10 mg/kg (5 min post-formalin)
Administration:

i.p. (30 min pre-formalin; 10 min pre-formalin; 5 min post-formalin)
Result:

Produced dose-dependent inhibition of both formalin-induced pain phases, with ID₅₀ values of 13.7 mg/kg (neurogenic phase, maximum inhibition 65%) and 5.6 mg/kg (inflammatory phase, maximum inhibition 76%).
Inhibited the neurogenic phase significantly when administered 10 mg/kg i.p. 10 minutes pre-formalin.
Inhibited the inflammatory phase by 42% when administered 10 mg/kg i.p. 5 minutes post-formalin.
Inhibited the inflammatory phase by 56% when administered 10 mg/kg i.p. 30 minutes pre-formalin.

化学情報

CAS 番号 306-60-5
性状 Solid
分子量 130.19
分子式 C₅H₁₄N₄
Color White to off-white
SMILES

NC(NCCCCN)=N
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Publications (1)

All

Sort by:

Journal Impact Factor

Psychopharmacology (Berl)

Agmatine ameliorates morphine-induced behavioral sensitization through blood-brain barrier protection and anti-neuroinflammatory effects in the nucleus accumbens. [Abstract]

2025 Oct 24. PMID: 41134339

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (272 KB)
SDS (392 KB)
- English - EN (392 KB)
- Français - FR (392 KB)
- Deutsch - DE (392 KB)
- Norwegian - NO (392 KB)
- Español - ES (392 KB)
- Swedish - SV (392 KB)
- Italian - IT (392 KB)
- Korean - KR (392 KB)
- Portuguese - PT (392 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Nudelman N. Aromatic nucleophilic substitution in aprotic solvents using hydrogen-bonded biological amines. Kinetic studies and quantum chemical calculations[J]. Journal of Physical Organic Chemistry, 2015.

[2]. Santos AR, et al. Mechanisms involved in the antinociception caused by agmatine in mice. Neuropharmacology. 2005;48(7):1021-1034. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

Agmatine

1 Cited Publications

100 mg お問い合わせ

Subscribe to the

MedChemExpress

Newsletter

MOQ

Minimum order quantity

100 mg

お問い合わせ在庫あり

Other size

お問い合わせ

Amount: USD 0.00

生物活性
- 製品説明
- IC₅₀ & Target
- 体内実験
化学情報
Publications (1)
純度とドキュメンテーション
参考文献

製品名:
製品番号:
数量:
日本の代理先をお選びください:

製品名:
CAS 番号:
生物種:
純度:
数量:

Agmatine

MedChemExpress（MCE）の使用を引用している文献 Agmatine

5-HT Receptor アイソフォーム固有の製品をすべて表示

Adrenergic Receptor アイソフォーム固有の製品をすべて表示

生物活性

化学情報

Publications (1)

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

Agmatine 関連分類

HY-WAA0304 関連分類