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United States

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製品番号: HY-168967

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BAY-277

BAY-277 is a selective METAP2 degrader and inhibitor. BAY-277 induces ubiquitination and proteasomal degradation of METAP2, triggers G1-phase cell cycle arrest, and inhibits angiogenesis and endothelial cell proliferation. BAY-277 serves as a chemical probe for investigating the biological functions of METAP2. BAY-277 is applicable to cancer-related research.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

分子式: C₄₄H₅₂N₈O₅
分子量:772.93

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (249 KB)

BAY-277 構造式

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- Cellular Effect
- 体外実験
化学情報
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関連分類
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生物活性

製品説明

IC₅₀ & Target

MetAp2

MetAP アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
HT-1080	DC₅₀	8.93 nM Compound: EUB0003014	Degradation in HT1080 cells (CE) (Capillary electrophoresis (CE)) Degradation in HT1080 cells (CE) (Capillary electrophoresis (CE))	10.6019/CHEMBL5463725
HUVEC	DC₅₀	0.2 nM Compound: EUB0003014	Degradation in HUVEC cells (WB) (Western Blot (WB)) Degradation in HUVEC cells (WB) (Western Blot (WB))	10.6019/CHEMBL5463725
HUVEC	IC₅₀	12 nM Compound: EUB0003014	2D HUVEC cells proliferation assay 2D HUVEC cells proliferation assay	10.6019/CHEMBL5463725

体外実験

BAY-277 degrades METAP2 in human umbilical vein endothelial cells (HUVEC) and HT1080 fibrosarcoma cells.
BAY-277 potently inhibits the enzymatic activity of recombinant human METAP2.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

分子量 772.93
分子式 C₄₄H₅₂N₈O₅
SMILES

O=C(N1CCC(C2=CC=C3C(CN(C4C(NC(CC4)=O)=O)C3=O)=C2)CC1)CCCCCN(CC5)CCC5C6=CC=C(C=C6)OC7=NN8C(C9=C7CCCC9)=NN=C8
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.