BAY-277
BAY-277, a chemical probe, is a METAP2 degrader, with IC50 values of 5.8 nM and 5.9 nM for hMETAP2 and mMETAP2, respectively.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C44H52N8O5
- 分子量:772.93
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HT-1080 | DC50 |
8.93 nM
Compound: EUB0003014
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Degradation in HT1080 cells (CE) (Capillary electrophoresis (CE))
Degradation in HT1080 cells (CE) (Capillary electrophoresis (CE))
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10.6019/CHEMBL5463725 |
| HUVEC | DC50 |
0.2 nM
Compound: EUB0003014
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Degradation in HUVEC cells (WB) (Western Blot (WB))
Degradation in HUVEC cells (WB) (Western Blot (WB))
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10.6019/CHEMBL5463725 |
| HUVEC | IC50 |
12 nM
Compound: EUB0003014
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2D HUVEC cells proliferation assay
2D HUVEC cells proliferation assay
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10.6019/CHEMBL5463725 |
BAY-277 exhibits DC50 of 8.93 nM for the degradation in HT1080 cells (CE), DC50 of 0.2 nM for the degradation in HUVEC cells (WB) and IC50 of 12 nM in the 2D HUVEC cells proliferation assay.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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分子量 772.93
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分子式 C44H52N8O5
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SMILES
O=C(N1CCC(C2=CC=C3C(CN(C4C(NC(CC4)=O)=O)C3=O)=C2)CC1)CCCCCN(CC5)CCC5C6=CC=C(C=C6)OC7=NN8C(C9=C7CCCC9)=NN=C8
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
BAY-277 関連分類
HY-168967 関連分類
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