BRD4-IN-42
BRD4-IN-42 is a BRD4 BD1 inhibitor with an IC50 of 108.50 nM. BRD4-IN-42 can be used for the synthesis of PROTACs and serves as the target protein moiety of PROTAC BET Degrader-18 (HY-184335). BRD4-IN-42 inhibits the proliferation of wild-type and SHP099-resistant acute myeloid leukemia cells. BRD4-IN-42 is applicable to research related to acute myeloid leukemia.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C30H36N4O7S
- 分子量:596.69
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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BRD4 108.50 nM (IC50) |
BRD4-IN-42 (compound 16) potently inhibits BRD4 BD1 in a cell-free TR-FRET assay with an IC50 of 108.50 nM[1].
BRD4-IN-42 (10 μM; 3-fold serial dilution across 10 data points) inhibits proliferation of wild-type MV4-11 acute myeloid leukemia cells with an IC50 of 493.95 nM[1].
BRD4-IN-42 (10 μM; 3-fold serial dilution across 10 data points) inhibits proliferation of SHP099-resistant MV4-11 acute myeloid leukemia cells with an IC50 of 365.3 nM[1].
BRD4-IN-42 can be used in the synthesis of PROTACs and serves as the target protein-binding moiety for PROTAC BET Degrader-18 (compound 36) (HY-184335)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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分子量 596.69
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分子式 C30H36N4O7S
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SMILES
CC(C1=C(NC(C(NC2=C(C=CC(S(=O)(N3CCOCC3)=O)=C2)OCCCC(NCC)=O)=O)=C1C4=CC=CC=C4)C)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
BRD4-IN-42 関連分類
HY-184339 関連分類
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- BRD4-IN-42
- Ligands for Target Protein for PROTAC
- Epigenetic Reader Domain
- acetylpyrrole scaffold BRD4 inhibitor
- competitive binding
- BRD4 BD1 domain binding
- hydrogen bond interaction with Asn140
- solvent-exposed side chain
- PROTAC warhead
- antiproliferative activity
- MV4-11 cells
- SHP099-resistant MV4-11 cells
- acute myeloid leukemia
- c-Myc downregulation
- Inhibitor
- inhibitor
- inhibit