CI-996
CI-996 is a potent, selective, orally active angiotensin II (Ang II) type 1 (AT1) receptor antagonist. In rat liver membranes CI-996 displaces specifically bind [125I]Ang II with an IC50 of 0.8 nM. CI-996 has blood pressure-lowering activity.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 150438-02-1
- 分子式: C27H22F3N7O3
- 分子量:549.50
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
Angiotensin Receptor アイソフォーム固有の製品をすべて表示
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生物活性
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AT1 Receptor |
In isolated rabbit aorta CI-996 produces a concentration-dependent inhibition of Ang II-induced contraction and decreased the maximal contractile response to Ang II. CI-996 has no effect on the contractile responses to KCl, norepinephrine or endothelin[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Orally administered CI-996 dose dependently loweres mean arterial blood pressure in conscious renal hypertensive rats, conscious sodium-depleted dogs, conscious sodium-depleted monkeys and conscious renal hypertensive monkeys[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 150438-02-1
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分子量 549.50
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分子式 C27H22F3N7O3
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SMILES
O=C(C1=C(N2C(C(C(F)(F)F)=O)=CC=C2)N=C(CCC)N1CC3=CC=C(C4=CC=CC=C4C5=NN=NN5)C=C3)O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
CI-996 関連分類
HY-19165 関連分類
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