Cibotercept
Based on 1 Customer Validation
Cibotercept (KER-012) is a novel, modified, investigational activin receptor type IIB (ActRIIB) ligand trap designed to target select TGF-β ligands, including activins A and B, GDFs 8 and 11, to rebalance the defective activin receptor type II signaling observed in PAH.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.85%
- CAS 番号: 2769700-97-0
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
生物活性
FPIA_[PROTEIN]2-FC
MSTN/INHBA/GDF11
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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FPIA_[PROTEIN]2-FC
ELISA, FACS, Functional assay
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Immobilized Activin A Protein, Human/Mouse/Rat (HEK293, HY-P70311) can bind Cibotercept. The EC50 for this effect is 32.97 ng/mL. -
Immobilized GDF-11/BMP-11 Protein, Human (HEK293, solution, HY-P70222Y) can bind Cibotercept. The EC50 for this effect is 66.34 ng/mL.
化学情報
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CAS 番号 2769700-97-0
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性状 Liquid
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Color Colorless to light yellow
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別名
KER-012
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輸送条件
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
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データシート (255 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)