Cimpuciclib tosylate
Based on 1 Customer Validation
Cimpuciclib tosylate is a selective CDK4 inhibitor (IC50: 0.49 nM) that has anti-tumor activity.
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- 純度: 99.65%
- CAS 番号: 2408872-84-2
- 分子式: C37H43FN8O4S
- 分子量:714.85
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保管条件:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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CDK4 0.49 nM (IC50) |
CDK6 9.56 nM (IC50) |
Cimpuciclib (example 63, 141.2 nM, 6 days) tosylate inhibits proliferation of colo205 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Colo205 cells
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Concentration:0-500 nM approximately
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Incubation Time:6 days
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Result:Inhibited cell proliferation with an IC50 value of 141.2 nM.
Cimpuciclib (5 mg/kg for rats, 50 mg/kg for colo205 tumor-bearing mice, oral administration) tosylate shows slow metabolic rate and maintains high concentration in the plasma[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Colo205 tumor-bearing mice[1]
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Dosage:50 mg/kg, twice a week
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Administration:Oral gavage
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Result:Inhibited tumor growth by 93.63%
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Animal Model:Rats, colo205 tumor-bearing mice[1]
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Dosage:5 mg/kg for rats, 50 mg/kg for colo205 tumor-bearing mice.
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Administration:Oral administration
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Result:Pharmacokinetic profile of Cimpuciclib (example 63).
dose Cmax (ng/mL) Tmax (h) AUC0-24 (ng/mL•h) t1/2 (h) 5 mg/kg (rats) 559.7 6 5414 2.4 50 mg/kg (mice) 7960 1 136782 14.8
化学情報
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CAS 番号 2408872-84-2
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性状 Solid
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分子量 714.85
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分子式 C37H43FN8O4S
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Color White to off-white
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SMILES
O=C(N1CCC(CC1)NC2CC2)C3=CC=C(NC4=NC(C5=CC6=C(N=C(C)N6C(C)C)C=C5)=C(F)C=N4)N=C3C.O=S(O)(C7=CC=C(C)C=C7)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶剤 & 溶解度
DMSO : 200 mg/mL (279.78 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (274 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
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- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 1.3989 mL | 6.9945 mL | 13.9889 mL | 34.9724 mL |
| 5 mM | 0.2798 mL | 1.3989 mL | 2.7978 mL | 6.9945 mL | |
| 10 mM | 0.1399 mL | 0.6994 mL | 1.3989 mL | 3.4972 mL | |
| 15 mM | 0.0933 mL | 0.4663 mL | 0.9326 mL | 2.3315 mL | |
| 20 mM | 0.0699 mL | 0.3497 mL | 0.6994 mL | 1.7486 mL | |
| 25 mM | 0.0560 mL | 0.2798 mL | 0.5596 mL | 1.3989 mL | |
| 30 mM | 0.0466 mL | 0.2331 mL | 0.4663 mL | 1.1657 mL | |
| 40 mM | 0.0350 mL | 0.1749 mL | 0.3497 mL | 0.8743 mL | |
| 50 mM | 0.0280 mL | 0.1399 mL | 0.2798 mL | 0.6994 mL | |
| 60 mM | 0.0233 mL | 0.1166 mL | 0.2331 mL | 0.5829 mL | |
| 80 mM | 0.0175 mL | 0.0874 mL | 0.1749 mL | 0.4372 mL | |
| 100 mM | 0.0140 mL | 0.0699 mL | 0.1399 mL | 0.3497 mL |
Cimpuciclib tosylate 関連分類
HY-112243A 関連分類
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