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United States

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製品番号: HY-P11918

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D-T7

D-T7 is a transferrin receptor (TfR) binding peptide that mediates brain-targeted delivery. D-T7 acts as a penetration enhancer and uptake promoter for nanoparticles in glioma tissues and target cells. D-T7 can be used in glioma research.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 2350190-98-4
分子式: C₄₁H₆₀N₁₄O₉
分子量:893.00

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

カスタムペプチド

D-T7 構造式

CAS 番号: 2350190-98-4

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

OthersAnti-cancer

Others

D-T7 peptide-modified PEGylated bilirubin nanoparticles (TBRNPs) (0.12-800 μM) exhibit extremely low cytotoxicity against bEnd.3 mouse brain microvascular endothelial cells, with approximately 80% cell viability observed even at concentrations as high as 10 μM^[1].

Anti-cancer

D-T7 peptide-modified CD&PTX co-loaded PEGylated bilirubin nanoparticles (CD&PTX@TBRNPs) exhibit significantly enhanced cytotoxicity against C6 glioma cells after 24 h, with an IC₅₀ of 1.39 μM (CD concentration), which is 8.78-fold lower than that of unmodified CD&PTX@BRNPs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

C6 glioma cells
Concentration:

CD concentrations corresponding to PTX concentrations of 0.2-405 nM
Incubation Time:

24 h
Result:

Achieved an IC₅₀ of 1.39 μM (based on CD concentration), which was 8.78-fold lower than the IC₅₀ of CD&PTX@BRNPs.

体内実験

Anti-cancerOthers

Anti-cancer

CD&PTX@TBRNPs (modified with D-T7 peptide) (Paclitaxel (HY-B0015) 1.7 mg/kg, intravenous injection; once every 2 days; 6 times total) extends the median survival time of Kunming mice bearing C6 glioma to 53 days, and exhibits superior anti-glioma efficacy and better biocompatibility compared with unmodified nanoparticles and free reagents^[1].

Others

Single-dose D-T7 peptide-modified nanoparticles selectively accumulate in glioma tissues of Kunming mice bearing C6 glioma, and the brain fluorescence intensity at 24 h post-injection is 7.89-fold higher than that of unmodified nanoparticles^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Kunming mice (male, 20 g)^[1]
Dosage:

Paclitaxel 1.7 mg/kg
Administration:

i.v.; every 2 days; 6 doses
Result:

Extended median survival time to 53 days, representing a 231% increase compared to the saline group, and a 23% increase compared to the unmodified CD&PTX@BRNPs group.
Showed the smallest glioma size among all treatment groups.
Exhibited no obvious body weight loss within 20 days of treatment.
Caused no significant toxicity to heart, liver, spleen, lung, or kidney compared to the saline group, with reduced nephrotoxicity relative to free CD&PTX and PTX@BRNPs groups.
Showed hematological parameters mostly within normal ranges, and lower hepatotoxicity than the free CD&PTX group.

化学情報

CAS 番号 2350190-98-4
分子量 893.00
分子式 C₄₁H₆₀N₁₄O₉
配列

d{HRPYIAH}
シーケンスの短縮

d{His-Arg-Pro-Tyr-Ile-Ala-His}
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Yu M, et al. D-T7 Peptide-Modified PEGylated Bilirubin Nanoparticles Loaded with Cediranib and Paclitaxel for Antiangiogenesis and Chemotherapy of Glioma. ACS applied materials & interfaces. 2019 Jan 09;11(1):176-186.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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