country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

STT3B - STT3 oligosaccharyltransferase complex catalytic subunit B Gene

Also Known as SIMP; CDG1X; STT3-B

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 201595

About STT3B

Cytogenetic location: 3p23 Genomic coordinates (GRCh38): 3:31,532,925-31,637,616 (from NCBI)

This gene has 7 transcripts (splice variants), 274 orthologues, 2 paralogues and is associated with 3 phenotypes. Ubiquitous expression in testis (RPKM 42.8), thyroid (RPKM 37.3) and 25 other tissues.

Summary

The protein encoded by this gene is a catalytic subunit of a protein complex that transfers oligosaccharides onto asparagine residues. Defects in this gene are a cause of congenital disorder of glycosylation Ix (CDG1X). [provided by RefSeq, Jun 2014]

STT3B Products (1)

mRNA	Protein	Name
NM_178862.3	NP_849193.1	dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	参考文献	由来
enables dolichyl-diphosphooligosaccharide-protein glycotransferase activity	IMP IMP: Inferred from mutant phenotype	19167329	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19167329	GOA

Biological Process GO Annotation	Evidence	参考文献	由来
involved in ERAD pathway	IMP IMP: Inferred from mutant phenotype	22607976	GOA
involved in co-translational protein modification	IMP IMP: Inferred from mutant phenotype	19167329	GOA
involved in glycoprotein catabolic process	IMP IMP: Inferred from mutant phenotype	22607976	GOA
involved in post-translational protein modification	IMP IMP: Inferred from mutant phenotype	19167329	GOA
involved in protein N-linked glycosylation	IDA IDA: Inferred from direct assay	31831667	GOA
involved in protein N-linked glycosylation	IMP IMP: Inferred from mutant phenotype	22467853	GOA
involved in protein N-linked glycosylation via asparagine	IMP IMP: Inferred from mutant phenotype	19167329	GOA
involved in response to unfolded protein	IMP IMP: Inferred from mutant phenotype	19167329	GOA

Cellular Component GO Annotation	Evidence	参考文献	由来
part of oligosaccharyltransferase complex	IDA IDA: Inferred from direct assay	22467853	GOA
part of oligosaccharyltransferase complex	IPI IPI: Inferred from physical interaction	31831667	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	28246125	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

STT3B Protein Structure

STT3

0
200
400
600
826 a.a.

Protein Preferred Names	Protein Names
dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B	STT3, subunit of the oligosaccharyltransferase complex, homolog B

STT3B Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	STT3B	Q8TCJ2	RPN1	Homo sapiens	P04843	Crosslink	30021884
Intra	STT3B	Q8TCJ2	RPN1	Homo sapiens	P04843	Anti Tag CoIP	35271311
Intra	STT3B	Q8TCJ2	INCA1	Homo sapiens	Q0VD86	Y2H Array	32296183
Intra	STT3B	Q8TCJ2	INCA1	Homo sapiens	Q0VD86	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

関連疾患

Diseases	Alias
Congenital Disorder Of Glycosylation, Type Ix	CDG1X Cdg Ix Cdgix Congenital Disorder Of Glycosylation 1x Stt3b-Cdg Cdg-Ix Congenital Disorder Of Glycosylation Type Ix Congenital Disorder Of Glycosylation Ix Cdg Syndrome Type Ix Carbohydrate Deficient Glycoprotein Syndrome Type Ix Congenital Disorder Of Glycosylation Type 1x Glycosylation, Congenital Disorder Of, Type Ix
Immunodeficiency, X-Linked, With Magnesium Defect, Epstein-Barr Virus Infection, And Neoplasia	XMEN X-Linked Immunodeficiency With Magnesium Defect, Epstein-Barr Virus Infection And Neoplasia X-Linked Immunodeficiency With Magnesium Defect, Epstein-Barr Virus Infection, And Neoplasia Immunodeficiency, X-Linked, With Magnesium Defect, Epstein-Barr Virus Infection And Neoplasia Cid Due To Magt1 Deficiency Combined Immunodeficiency Due To Magt1 Deficiency X-Linked Immunodeficiency With Magnesium Defect, Epstein-Barr Virus Infection An X-Linked Magnesium Deficiency With Epstein-Barr Virus Infection And Neoplasia
Immunodeficiency 47	Congenital Disorder Of Glycosylation Type Ii CDG2E Congenital Disorder Of Glycosylation Type Iie IMD47 Cdg2s Cdg Iis Cdgiis Immunodeficiency And Hepatopathy With Or Without Neurologic Features Congenital Disorder Of Glycosylation, Type Ii CDG1I Congenital Disorder Of Glycosylation, Type Iie Cdg Iie Congenital Disorder Of Glycosylation Type 2e Congenital Disorder Of Glycosylation, Type Iis Cdg Ii Cdgii Cdgiie Carbohydrate Deficient Glycoprotein Syndrome Type Iie Cdg Syndrome Type Iie Congenital Disorder Of Glycosylation Ii Congenital Disorder Of Glycosylation 1i Cdg-Iie Alg2-Cdg Cdg-Ii Glycosylation, Congenital Disorder Of, Type Ii Cdgiide Congenital Disorder Of Glycosylation Type Iis Cog7-Cdg Cdg Syndrome Type Ii Carbohydrate Deficient Glycoprotein Syndrome Type Ii Congenital Disorder Of Glycosylation Type 1i Mannosyltransferase 2 Deficiency Congenital Disorder Of Glycosylation 2e Congenital Disorder Of Glycosylation 2s Congenital Disorders Of Glycosylation Type Ii Glycosylation, Congenital Disorder Of, Type Iie Immunodeficiency, Type 47 Congenital Disorder Of Glycosylation Type 2a
Louping Ill
Autosomal Recessive Intellectual Developmental Disorder	Mental Retardation, Autosomal Recessive Autosomal Recessive Mental Retardation Autosomal Recessive Non-Syndromic Mental Retardation Autosomal Recessive Non-Syndromic Intellectual Disability
Congenital Disorder Of Glycosylation, Type In	Congenital Disorder Of Glycosylation CDG1N Congenital Disorders Of Glycosylation Cdg In Cdgin Congenital Disorder Of Glycosylation 1n Carbohydrate-Deficient Glycoprotein Syndrome Cdg Rft1-Cdg Cdg-In Congenital Disorder Of Glycosylation Type In Carbohydrate Deficient Glycoprotein Syndrome Cdg Syndrome Congenital Disorder Of Glycosylation In Carbohydrate-Deficient Glycoprotein Syndromes Cdg Syndrome Type In Carbohydrate Deficient Glycoprotein Syndrome Type In Congenital Disorder Of Glycosylation Type 1n Man5glcnac2-Pp-Dol Flippase Deficiency Glycosylation, Congenital Disorder Of Glycosylation, Congenital Disorder Of, Type In

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-117383	NGI-1	Inhibitor	99.97%	Unkown
HY-175674	NGI-235	Inhibitor	99.70%	Unkown
HY-RS13971	STT3B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22839	Stt3b Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS29354	Stt3b Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Mus musculus	STT3B	MGD	MGI:1915542
Felis catus	STT3B	VGNC	VGNC:65804
Bos taurus	STT3B	VGNC	VGNC:35428
Macaca mulatta	STT3B	VGNC	VGNC:78245
Canis familiaris	STT3B	VGNC	VGNC:52904
Rattus norvegicus	STT3B	RGD	RGD:1311563
Others	STT3B	NCBI