CRNKL1 - crooked neck pre-mRNA splicing factor 1 Gene

Also Known as CLF; CRN; Clf1; HCRN; SYF3; MSTP021

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 51340

About CRNKL1

Cytogenetic location: 20p11.23 Genomic coordinates (GRCh38): 20:20,034,368-20,056,046 (from NCBI)

This gene has 7 transcripts (splice variants), 219 orthologues, 2 paralogues and is associated with 64 phenotypes. Ubiquitous expression in bone marrow (RPKM 8.6), testis (RPKM 8.2) and 25 other tissues.

Summary

The crooked neck (crn) gene of Drosophila is essential for embryogenesis and is thought to be involved in cell cycle progression and pre-mRNA splicing. A protein encoded by this human locus has been found to localize to pre-mRNA splicing complexes in the nucleus and is necessary for pre-mRNA splicing. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2013]

CRNKL1 Products (5)

mRNA Protein Name
NM_001278625.2 NP_001265554.1 crooked neck-like protein 1 isoform b
NM_001278626.2 NP_001265555.1 crooked neck-like protein 1 isoform c
NM_001278627.2 NP_001265556.1 crooked neck-like protein 1 isoform c
NM_001278628.2 NP_001265557.1 crooked neck-like protein 1 isoform d
NM_016652.6 NP_057736.4 crooked neck-like protein 1 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables RNA binding IDA
IDA: Inferred from direct assay
12084575 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
22365833 GOA
Biological Process GO Annotation Evidence 参考文献 由来
involved in mRNA splicing, via spliceosome IDA
IDA: Inferred from direct assay
28076346 GOA
involved in spliceosomal complex assembly IDA
IDA: Inferred from direct assay
12084575 GOA
Cellular Component GO Annotation Evidence 参考文献 由来
part of U2-type catalytic step 2 spliceosome IDA
IDA: Inferred from direct assay
28076346 GOA
part of catalytic step 2 spliceosome IDA
IDA: Inferred from direct assay
11991638 GOA
located in nucleus IDA
IDA: Inferred from direct assay
28076346 GOA
part of spliceosomal complex IDA
IDA: Inferred from direct assay
11991638 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CRNKL1 Protein Structure

HAT

HAT: HAT (Half-A-TPR) repeat (256 - 286)

HAT

HAT: HAT (Half-A-TPR) repeat (357 - 388)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 848 a.a.
Protein Preferred Names Protein Names

crooked neck-like protein 1

  • Crn, crooked neck-like 1

CRNKL1 Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
CRNKL1 Q9BZJ0 CCDC12 Homo sapiens Q8WUD4
Anti Tag CoIP
22365833
Cross: Cross-species interaction Intra: Intraspecies interaction

関連疾患

Diseases Alias
Skin Squamous Cell Carcinoma

  • Squamous Cell Carcinoma Of Skin

  • Epidermoid Skin Carcinoma

  • Squamous Cell Carcinoma Of The Skin

  • Squamous Cell Epithelioma Of Skin

  • Cutaneous Squamous Cell Carcinoma

  • Scc - [Squamous Cell Carcinoma] Of Skin
Skin Melanoma

  • Cutaneous Melanoma

  • Malignant Ear Melanoma

  • Malignant Lip Melanoma

  • Malignant Lower Limb Melanoma

  • Malignant Melanoma Of Ear And/Or External Auricular Canal

  • Malignant Melanoma Of Skin Of Lower Limb

  • Malignant Melanoma Of Skin Of Trunk Except Scrotum

  • Malignant Melanoma Of Skin Of Upper Limb

  • Malignant Neck Melanoma

  • Malignant Scalp Melanoma

  • Malignant Trunk Melanoma

  • Malignant Upper Limb Melanoma

  • Melanoma, Cutaneous Malignant

  • Melanoma

  • Malignant Melanoma Of Skin

  • Melanoma Nos

  • Malignant Mole, Meaning Melanoma Of Unspecified Site

  • Melanoma Of Unspecified Site

  • Cutaneous Malignant Melanoma

  • Mm - [Malignant Melanoma]
Fanconi Anemia, Complementation Group G

  • Fanconi Anemia Complementation Group G

  • FANCG
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS03191 CRNKL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Rattus norvegicus CRNKL1 RGD RGD:620507
Felis catus CRNKL1 VGNC VGNC:61187
Macaca mulatta CRNKL1 VGNC VGNC:71412
Mus musculus CRNKL1 MGD MGI:1914127
Bos taurus CRNKL1 VGNC VGNC:27721
Canis familiaris CRNKL1 VGNC VGNC:39625
Others CRNKL1 NCBI