NIP7 - nucleolar pre-rRNA processing protein NIP7 Gene

Also Known as KD93; CGI-37; HSPC031

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 51388

About NIP7

Cytogenetic location: 16q22.1 Genomic coordinates (GRCh38): 16:69,339,772-69,343,106 (from NCBI)

This gene has 8 transcripts (splice variants), 223 orthologues and 2 paralogues. Ubiquitous expression in lymph node (RPKM 9.5), appendix (RPKM 8.7) and 25 other tissues.

Summary

Enables RNA binding activity. Predicted to be involved in ribosomal large subunit biogenesis. Located in cytosol; nucleolus; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

NIP7 Products (2)

mRNA Protein Name
NM_001199434.2 NP_001186363.1 60S ribosome subunit biogenesis protein NIP7 homolog isoform 2
NM_016101.5 NP_057185.1 60S ribosome subunit biogenesis protein NIP7 homolog isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence 参考文献 由来
enables protein binding IPI
IPI: Inferred from physical interaction
14660641 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NIP7 Protein Structure

UPF0113

UPF0113: Uncharacterised protein family (UPF0113) (2 - 175)

  • 0
  • 100
  • 180 a.a.
Protein Preferred Names Protein Names

60S ribosome subunit biogenesis protein NIP7 homolog

  • NIP7, nucleolar pre-rRNA processing protein

NIP7 Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
NIP7 Q9Y221 NECAB2 Homo sapiens Q7Z6G3-2
Validated Y2H
25416956
Intra
NIP7 Q9Y221 NOP2 Homo sapiens P46087
Anti Tag CoIP
33961781
Intra
NIP7 Q9Y221 LZTS2 Homo sapiens Q9BRK4
Y2H Prey Pooling
25416956
Intra
NIP7 Q9Y221 CRX Homo sapiens O43186
Validated Y2H
25416956
Intra
NIP7 Q9Y221 CRX Homo sapiens O43186
Y2H Prey Pooling
25416956
Intra
NIP7 Q9Y221 OPTN Homo sapiens Q96CV9
Validated Y2H
32814053
Intra
NIP7 Q9Y221 OPTN Homo sapiens Q96CV9
Y2H Array
32814053
Intra
NIP7 Q9Y221 OPTN Homo sapiens Q96CV9
Y2H Pooling
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant NIP7 Proteins

製品番号 製品名 アクセッション番号 純度
HY-P71162 NIP7 Protein, Human (His) Q9Y221-1 (M1-T180) ≥ 95%, as determined by reducing SDS-PAGE.

関連疾患

Diseases Alias
Shwachman-Diamond Syndrome 1

  • Shwachman-Diamond Syndrome

  • Shwachman Syndrome

  • Shwachman-Bodian-Diamond Syndrome

  • Sds

  • Pancreatic Insufficiency And Bone Marrow Dysfunction

  • Shwachman-Bodian Syndrome

  • SDS1

  • Lipomatosis Of Pancreas, Congenital

  • Congenital Lipomatosis Of Pancreas

  • Shwachman-Diamond Type Metaphyseal Dysplasia

  • Metaphyseal Chondrodysplasia, Shwachman Type

  • Shwachman-Diamond-Oski Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS09301 NIP7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19924 Nip7 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26426 Nip7 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Bos taurus NIP7 VGNC VGNC:32080
Mus musculus NIP7 MGD MGI:1913414
Felis catus NIP7 VGNC VGNC:63806
Canis familiaris NIP7 VGNC VGNC:43814
Rattus norvegicus NIP7 RGD RGD:620069
Macaca mulatta NIP7 VGNC VGNC:99527
Others NIP7 NCBI