NOP2 - NOP2 nucleolar protein Gene

Also Known as NOL1; p120; NSUN1; NOP120

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4839

About NOP2

Cytogenetic location: 12p13.31 Genomic coordinates (GRCh38): 12:6,556,871-6,568,291 (from NCBI)

This gene has 23 transcripts (splice variants), 171 orthologues and 2 paralogues. Ubiquitous expression in lymph node (RPKM 12.9), bone marrow (RPKM 12.9) and 25 other tissues.

Summary

Enables RNA binding activity. Involved in positive regulation of cell population proliferation; regulation of signal transduction by p53 class mediator; and ribosomal large subunit assembly. Located in nucleolus. [provided by Alliance of Genome Resources, Apr 2022]

NOP2 Products (5)

mRNA Protein Name
NM_001033714.3 NP_001028886.1 probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase isoform 1
NM_001258308.2 NP_001245237.1 probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase isoform 2
NM_001258309.2 NP_001245238.1 probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase isoform 3
NM_001258310.2 NP_001245239.1 probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase isoform 4
NM_006170.4 NP_006161.2 probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase isoform 1
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12080348 GOA
enables rRNA (cytosine-C5-)-methyltransferase activity IDA
IDA: Inferred from direct assay
26196125 GOA
enables rRNA (cytosine-C5-)-methyltransferase activity IMP
IMP: Inferred from mutant phenotype
36161484 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of cell population proliferation IDA
IDA: Inferred from direct assay
1394192 GOA
involved in rRNA processing IDA
IDA: Inferred from direct assay
36161484 GOA
involved in regulation of signal transduction by p53 class mediator IMP
IMP: Inferred from mutant phenotype
24120868 GOA
involved in ribosomal large subunit assembly IMP
IMP: Inferred from mutant phenotype
24120868 GOA
involved in ribosomal large subunit biogenesis IDA
IDA: Inferred from direct assay
36161484 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleolus IDA
IDA: Inferred from direct assay
8089149 GOA
located in nucleus IDA
IDA: Inferred from direct assay
36161484 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NOP2 Protein Structure

Methyltr_RsmB-F

Methyltr_RsmB-F: 16S rRNA methyltransferase RsmB/F (300 - 585)

P120R

P120R: P120R (NUC006) repeat (623 - 644)

P120R

P120R: P120R (NUC006) repeat (683 - 705)

P120R

P120R: P120R (NUC006) repeat (749 - 768)

  • 0
  • 200
  • 400
  • 600
  • 812 a.a.
Protein Preferred Names Protein Names

probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase

  • NOL1/NOP2/Sun domain family, member 1

NOP2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
NOP2 P46087 MT1F Homo sapiens P04733 25416956
Intra
NOP2 P46087 MT1F Homo sapiens P04733 25416956
Intra
NOP2 P46087 RBM28 Homo sapiens Q9NW13 33961781
Intra
NOP2 P46087 KPNA6 Homo sapiens O60684 25416956
Intra
NOP2 P46087 CDCA7L Homo sapiens Q96GN5 25416956
Intra
NOP2 P46087 CDCA7L Homo sapiens Q96GN5 25416956
Intra
NOP2 P46087 NIP7 Homo sapiens Q9Y221 33961781
Intra
NOP2 P46087 NIP7 Homo sapiens Q9Y221 35271311
Intra
NOP2 P46087 NIP7 Homo sapiens Q9Y221 30021884
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Dubowitz Syndrome
  • Dubowitz'S Syndrome

  • Dwarfism-Eczema-Peculiar Facies Syndrome

  • Intrauterine Growth Restriction, Short Stature, Microcephaly, Mild Intellectual Disability With Behavior Problems, Eczema, And Unusual And Distinctive Faci

B-Lymphoblastic Leukemia/Lymphoma With Hyperdiploidy
  • B-All With Hyperdiploidy

  • B Lymphoblastic Leukemia Lymphoma With Hyperdiploidy

Cardiomyopathy, Familial Restrictive, 1
  • RCM1

  • Restrictive Cardiomyopathy 1

  • Rcm

  • Familial Restrictive Cardiomyopathy 1

  • Cardiomyopathy, Familial Restrictive 1

  • Cardiomyopathy, Restrictive, Familial, Type 1

  • Rcm-1

Cri-Du-Chat Syndrome
  • 5p Deletion Syndrome

  • 5p Partial Monosomy Syndrome

  • Monosomy 5p

  • Cat Cry Syndrome

  • Chromosome 5p Deletion Syndrome

  • Cri Du Chat Syndrome

  • 5p- Syndrome

  • 5p Minus Syndrome

  • Chromosome 5p- Syndrome

  • Chromosome 5 Short Arm Deletion Syndrome

  • Chromosome 5p Deletion

  • Deletion 5p

  • Cri Du Chat

  • 5p Partial Deletion Syndrome

  • Partial Deletion Of Short Arm Of Chromosome 5 Syndrome

Lung Cancer Susceptibility 3
  • Lung Adenocarcinoma

  • Adenocarcinoma Of Lung

  • LNCR3

  • Adenocarcinoma Of Lung, Susceptibility To

  • Bronchogenic Lung Adenocarcinoma

  • Nonsmall Cell Adenocarcinoma

  • Adenocarcinoma Lung

  • Lung Adenocarcinomas

  • Non-Small Cell Adenocarcinoma

Williams-Beuren Syndrome
  • Williams Syndrome

  • WBS

  • Wms

  • Deletion 7q11.23

  • Monosomy 7q11.23

  • Chromosome 7q11.23 Deletion Syndrome, 1.5- To 1.8-Mb

  • Fanconi Schlesinger Syndrome

  • Beuren Syndrome

  • Elfin Facies Syndrome

  • Elfin Facies With Hypercalcemia

  • Hypercalcemia-Supravalvar Aortic Stenosis

  • Ws

Autosomal Recessive Intellectual Developmental Disorder
  • Mental Retardation, Autosomal Recessive

  • Autosomal Recessive Mental Retardation

  • Autosomal Recessive Non-Syndromic Mental Retardation

  • Autosomal Recessive Non-Syndromic Intellectual Disability

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Rattus norvegicus NOP2 RGD RGD:1304616
Macaca mulatta NOP2 VGNC VGNC:75365
Mus musculus NOP2 MGD MGI:107891
Felis catus NOP2 VGNC VGNC:106435
Canis familiaris NOP2 VGNC VGNC:43889
Bos taurus NOP2 VGNC VGNC:32167
Others NOP2 NCBI