NOP2 - NOP2 nucleolar protein Gene
Also Known as NOL1; p120; NSUN1; NOP120
Species: Homo sapiens
About NOP2
This gene has 23 transcripts (splice variants), 171 orthologues and 2 paralogues. Ubiquitous expression in lymph node (RPKM 12.9), bone marrow (RPKM 12.9) and 25 other tissues.
Summary
Enables RNA binding activity. Involved in positive regulation of cell population proliferation; regulation of signal transduction by p53 class mediator; and ribosomal large subunit assembly. Located in nucleolus. [provided by Alliance of Genome Resources, Apr 2022]
NOP2 Products (5)
| mRNA | Protein | Name |
|---|---|---|
| NM_001033714.3 | NP_001028886.1 | probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase isoform 1 |
| NM_001258308.2 | NP_001245237.1 | probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase isoform 2 |
| NM_001258309.2 | NP_001245238.1 | probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase isoform 3 |
| NM_001258310.2 | NP_001245239.1 | probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase isoform 4 |
| NM_006170.4 | NP_006161.2 | probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase isoform 1 |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
12080348 | GOA |
| enables rRNA (cytosine-C5-)-methyltransferase activity |
IDA
IDA: Inferred from direct assay
|
26196125 | GOA |
| enables rRNA (cytosine-C5-)-methyltransferase activity |
IMP
IMP: Inferred from mutant phenotype
|
36161484 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in positive regulation of cell population proliferation |
IDA
IDA: Inferred from direct assay
|
1394192 | GOA |
| involved in rRNA processing |
IDA
IDA: Inferred from direct assay
|
36161484 | GOA |
| involved in regulation of signal transduction by p53 class mediator |
IMP
IMP: Inferred from mutant phenotype
|
24120868 | GOA |
| involved in ribosomal large subunit assembly |
IMP
IMP: Inferred from mutant phenotype
|
24120868 | GOA |
| involved in ribosomal large subunit biogenesis |
IDA
IDA: Inferred from direct assay
|
36161484 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in nucleolus |
IDA
IDA: Inferred from direct assay
|
8089149 | GOA |
| located in nucleus |
IDA
IDA: Inferred from direct assay
|
36161484 | GOA |
NOP2 Protein Structure
Methyltr_RsmB-F: 16S rRNA methyltransferase RsmB/F (300 - 585)
P120R: P120R (NUC006) repeat (623 - 644)
P120R: P120R (NUC006) repeat (683 - 705)
P120R: P120R (NUC006) repeat (749 - 768)
- 0
- 200
- 400
- 600
- 812 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase |
|
NOP2 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
NOP2 | P46087 | MT1F | Homo sapiens | P04733 | 25416956 | |
|
Intra
|
NOP2 | P46087 | MT1F | Homo sapiens | P04733 | 25416956 | |
|
Intra
|
NOP2 | P46087 | RBM28 | Homo sapiens | Q9NW13 | 33961781 | |
|
Intra
|
NOP2 | P46087 | KPNA6 | Homo sapiens | O60684 | 25416956 | |
|
Intra
|
NOP2 | P46087 | CDCA7L | Homo sapiens | Q96GN5 | 25416956 | |
|
Intra
|
NOP2 | P46087 | CDCA7L | Homo sapiens | Q96GN5 | 25416956 | |
|
Intra
|
NOP2 | P46087 | NIP7 | Homo sapiens | Q9Y221 | 33961781 | |
|
Intra
|
NOP2 | P46087 | NIP7 | Homo sapiens | Q9Y221 | 35271311 | |
|
Intra
|
NOP2 | P46087 | NIP7 | Homo sapiens | Q9Y221 | 30021884 |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Dubowitz Syndrome |
|
|
| B-Lymphoblastic Leukemia/Lymphoma With Hyperdiploidy |
|
|
| Cardiomyopathy, Familial Restrictive, 1 |
|
|
| Cri-Du-Chat Syndrome |
|
|
| Lung Cancer Susceptibility 3 |
|
|
| Williams-Beuren Syndrome |
|
|
| Autosomal Recessive Intellectual Developmental Disorder |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Rattus norvegicus | NOP2 | RGD | RGD:1304616 |
| Macaca mulatta | NOP2 | VGNC | VGNC:75365 |
| Mus musculus | NOP2 | MGD | MGI:107891 |
| Felis catus | NOP2 | VGNC | VGNC:106435 |
| Canis familiaris | NOP2 | VGNC | VGNC:43889 |
| Bos taurus | NOP2 | VGNC | VGNC:32167 |
| Others | NOP2 | NCBI |