SYTL2 - synaptotagmin like 2 Gene

Also Known as EXO4; SLP2; SLP2A; SGA72M; CHR11SYT; PPP1R151

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 54843

About SYTL2

Cytogenetic location: 11q14.1 Genomic coordinates (GRCh38): 11:85,694,229-85,854,870 (from NCBI)

This gene has 29 transcripts (splice variants), 199 orthologues and 31 paralogues. Broad expression in stomach (RPKM 22.4), colon (RPKM 16.3) and 17 other tissues.

Summary

The protein encoded by this gene is a synaptotagmin-like protein (SLP) that belongs to a C2 domain-containing protein family. The SLP homology domain (SHD) of this protein has been shown to specifically bind the GTP-bound form of Ras-related protein Rab-27A (RAB27A). This protein plays a role in RAB27A-dependent vesicle trafficking and controls melanosome distribution in the cell periphery. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Jun 2009]

SYTL2 Products (47)

mRNA Protein Name
NM_001162951.4 NP_001156423.1 synaptotagmin-like protein 2 isoform g
NM_001162952.3 NP_001156424.1 synaptotagmin-like protein 2 isoform h
NM_001162953.4 NP_001156425.1 synaptotagmin-like protein 2 isoform i
NM_001289608.2 NP_001276537.1 synaptotagmin-like protein 2 isoform j
NM_001289609.2 NP_001276538.1 synaptotagmin-like protein 2 isoform k
NM_001289610.2 NP_001276539.1 synaptotagmin-like protein 2 isoform h
NM_001365826.2 NP_001352755.1 synaptotagmin-like protein 2 isoform l
NM_001365827.2 NP_001352756.1 synaptotagmin-like protein 2 isoform m
NM_001365828.2 NP_001352757.1 synaptotagmin-like protein 2 isoform b
NM_001365829.2 NP_001352758.1 synaptotagmin-like protein 2 isoform b
NM_001365830.2 NP_001352759.1 synaptotagmin-like protein 2 isoform b
NM_001365831.2 NP_001352760.1 synaptotagmin-like protein 2 isoform n
NM_001365832.2 NP_001352761.1 synaptotagmin-like protein 2 isoform o
NM_001365833.2 NP_001352762.1 synaptotagmin-like protein 2 isoform f
NM_001365834.2 NP_001352763.1 synaptotagmin-like protein 2 isoform p
NM_001365835.2 NP_001352764.1 synaptotagmin-like protein 2 isoform q
NM_001394447.1 NP_001381376.1 synaptotagmin-like protein 2 isoform r
NM_001394448.1 NP_001381377.1 synaptotagmin-like protein 2 isoform s
NM_001394449.1 NP_001381378.1 synaptotagmin-like protein 2 isoform s
NM_001394450.1 NP_001381379.1 synaptotagmin-like protein 2 isoform t
NM_001394451.1 NP_001381380.1 synaptotagmin-like protein 2 isoform u
NM_001394452.1 NP_001381381.1 synaptotagmin-like protein 2 isoform v
NM_001394453.1 NP_001381382.1 synaptotagmin-like protein 2 isoform w
NM_001394454.1 NP_001381383.1 synaptotagmin-like protein 2 isoform w
NM_001394455.1 NP_001381384.1 synaptotagmin-like protein 2 isoform x
NM_001394456.1 NP_001381385.1 synaptotagmin-like protein 2 isoform x
NM_001394457.1 NP_001381386.1 synaptotagmin-like protein 2 isoform g
NM_001394458.1 NP_001381387.1 synaptotagmin-like protein 2 isoform g
NM_001394459.1 NP_001381388.1 synaptotagmin-like protein 2 isoform g
NM_001394460.1 NP_001381389.1 synaptotagmin-like protein 2 isoform y
NM_001394461.1 NP_001381390.1 synaptotagmin-like protein 2 isoform z
NM_001394462.1 NP_001381391.1 synaptotagmin-like protein 2 isoform aa
NM_001394464.1 NP_001381393.1 synaptotagmin-like protein 2 isoform bb
NM_001394465.1 NP_001381394.1 synaptotagmin-like protein 2 isoform cc
NM_001394466.1 NP_001381395.1 synaptotagmin-like protein 2 isoform dd
NM_001394467.1 NP_001381396.1 synaptotagmin-like protein 2 isoform ee
NM_001394468.1 NP_001381397.1 synaptotagmin-like protein 2 isoform ff
NM_001394469.1 NP_001381398.1 synaptotagmin-like protein 2 isoform gg
NM_001394470.1 NP_001381399.1 synaptotagmin-like protein 2 isoform hh
NM_001394471.1 NP_001381400.1 synaptotagmin-like protein 2 isoform ii
NM_001394472.1 NP_001381401.1 synaptotagmin-like protein 2 isoform ii
NM_001394473.1 NP_001381402.1 synaptotagmin-like protein 2 isoform jj
NM_032943.5 NP_116561.1 synaptotagmin-like protein 2 isoform a
NM_206927.4 NP_996810.2 synaptotagmin-like protein 2 isoform c
NM_206928.4 NP_996811.2 synaptotagmin-like protein 2 isoform d
NM_206929.4 NP_996812.1 synaptotagmin-like protein 2 isoform b
NM_206930.4 NP_996813.1 synaptotagmin-like protein 2 isoform f

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables phosphatase binding IDA
IDA: Inferred from direct assay
19389623 GOA
enables phosphatidylinositol-4,5-bisphosphate binding IMP
IMP: Inferred from mutant phenotype
17182843 GOA
enables phosphatidylserine binding IMP
IMP: Inferred from mutant phenotype
17182843 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
15231748 GOA
Biological Process GO Annotation Evidence 参考文献 由来
involved in exocytosis IDA
IDA: Inferred from direct assay
18812475 GOA
involved in vesicle docking involved in exocytosis IDA
IDA: Inferred from direct assay
18812475 GOA
Cellular Component GO Annotation Evidence 参考文献 由来
located in cytoplasm IDA
IDA: Inferred from direct assay
18812475 GOA
located in exocytic vesicle IDA
IDA: Inferred from direct assay
18812475 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
17182843 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SYTL2 Protein Structure

FYVE_2

FYVE_2: FYVE-type zinc finger (6 - 52)

C2

C2: C2 domain (645 - 733)

C2

C2: C2 domain (795 - 879)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 934 a.a.
Protein Preferred Names Protein Names

synaptotagmin-like protein 2

  • breast cancer-associated antigen SGA-72M

SYTL2 Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
SYTL2 Q9HCH5 PPP1CA Homo sapiens P62136
Pull Down
19389623
Cross: Cross-species interaction Intra: Intraspecies interaction

関連疾患

Diseases Alias
Griscelli Syndrome

  • Chediak-Higashi-Like Syndrome

  • Griscelli-Prunieras Syndrome

  • Partial Albinism-Immunodeficiency Syndrome

  • Griscelli Disease

  • Gs

  • Hypopigmentation Immunodeficiency Disease

  • Partial Albinism With Immunodeficiency

  • Immunodeficiency Syndrome With Hypopigmentation

  • Hypopigmentation-Immunodeficiency Disease
Griscelli Syndrome, Type 2

  • Griscelli Syndrome Type 2

  • GS2

  • Griscelli Syndrome With Hemophagocytic Syndrome

  • Partial Albinism And Immunodeficiency Syndrome

  • Paid Syndrome

  • Hypopigmentation-Immunodeficiency With Or Without Neurologic Impairment Syndrome

  • Griscelli-Prunieras Syndrome Type 2

  • Griscelli-Pruniéras Syndrome Type 2

  • Griscelli Syndrome 2
Tinea Nigra

  • Microsporosis Nigra

  • Infection By Cladosporium Werneckii

  • Keratomycosis Nigricans

  • Tinea Palmaris Nigra

  • Keratomycosis Nigricans Palmaris
Piebald Trait

  • Piebaldism

  • PBT

  • Partial Albinism

  • Albinoidism, Oculocutaneous, Autosomal Dominant
Griscelli Syndrome, Type 3

  • Griscelli Syndrome Type 3

  • GS3

  • Griscelli-Prunieras Syndrome Type 3

  • Hypomelanosis With No Immunologic Or Neurologic Manifestations

  • Griscelli Syndrome 3
Hermansky-Pudlak Syndrome

  • Hps

  • Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Cells

  • Hermanski-Pudlak Syndrome

  • Hermansky Pudlak Syndrome

  • Platelet Storage Pool Deficiency
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS14123 SYTL2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Macaca mulatta SYTL2 VGNC VGNC:78123
Felis catus SYTL2 VGNC VGNC:81930
Rattus norvegicus SYTL2 RGD RGD:1307647
Canis familiaris SYTL2 VGNC VGNC:52293
Mus musculus SYTL2 MGD MGI:1933366
Others SYTL2 NCBI