GALNT14 - polypeptide N-acetylgalactosaminyltransferase 14 Gene

Also Known as GALNT15; GalNac-T10; GalNac-T14

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 79623

About GALNT14

Cytogenetic location: 2p23.1 Genomic coordinates (GRCh38): 2:30,886,782-31,138,440 (from NCBI)

This gene has 15 transcripts (splice variants), 215 orthologues and 19 paralogues. Biased expression in kidney (RPKM 5.0), esophagus (RPKM 0.7) and 7 other tissues.

Summary

This gene encodes a Golgi protein which is a member of the polypeptide N-acetylgalactosaminyltransferase (ppGalNAc-Ts) protein family. These Enzymes catalyze the transfer of N-acetyl-D-galactosamine (GalNAc) to the hydroxyl groups on serines and threonines in target peptides. The encoded protein has been shown to transfer GalNAc to large proteins like mucins. Alterations in this gene may play a role in Cancer progression and response to chemotherapy. [provided by RefSeq, Jun 2016]

GALNT14 Products (6)

mRNA Protein Name
NM_001253826.2 NP_001240755.1 polypeptide N-acetylgalactosaminyltransferase 14 isoform 2
NM_001253827.2 NP_001240756.1 polypeptide N-acetylgalactosaminyltransferase 14 isoform 3
NM_001329095.2 NP_001316024.1 polypeptide N-acetylgalactosaminyltransferase 14 isoform 4
NM_001329096.2 NP_001316025.1 polypeptide N-acetylgalactosaminyltransferase 14 isoform 3
NM_001329097.2 NP_001316026.1 polypeptide N-acetylgalactosaminyltransferase 14 isoform 6
NM_024572.4 NP_078848.2 polypeptide N-acetylgalactosaminyltransferase 14 isoform 1

GALNT14 Protein Structure

Glycos_transf_2

Glycos_transf_2: Glycosyl transferase family 2 (114 - 268)

Glyco_transf_7C

Glyco_transf_7C: N-terminal domain of galactosyltransferase (278 - 336)

Ricin_B_lectin

Ricin_B_lectin: Ricin-type beta-trefoil lectin domain (424 - 547)

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  • 552 a.a.
Protein Preferred Names Protein Names

polypeptide N-acetylgalactosaminyltransferase 14

  • UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 14

関連疾患

Diseases Alias
Hydrops Fetalis, Nonimmune

  • Hydrops Fetalis

  • Non-Immune Hydrops Fetalis

  • NIHF

  • Familial Non-Immune Hydrops Fetalis

  • Hydrops Fetalis Nonimmune

  • Idiopathic Hydrops Fetalis

  • Hb Bart'S Hydrops Fetalis

  • Alpha-Thalassemia Hydrops Fetalis

  • Alpha-Thalassemia Major

  • Hemoglobin Bart'S Hydrops Fetalis

  • Homozygous Alpha0-Thalassemia

  • Fetal Anasarca

  • Fetal Hydrops

  • Generalized Fetal Edema

  • Hf

  • Non-Immune Hf

  • Non-Immune Fetal Edema

  • Non-Immune Fetal Hydrops

  • Hydrops Fetalis, Non-Immune

  • Hemoglobin Bart'S Hydrops Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS05252 GALNT14 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-E70295 N-Acetylgalactosaminyltransferase 14 / Unkown
HY-RS21238 Galnt14 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27755 Galnt14 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Mus musculus GALNT14 MGD MGI:1918935
Canis familiaris GALNT14 VGNC VGNC:41089
Bos taurus GALNT14 VGNC VGNC:29227
Rattus norvegicus GALNT14 RGD RGD:1310068
Felis catus GALNT14 VGNC VGNC:62446
Macaca mulatta GALNT14 VGNC VGNC:72764
Others GALNT14 NCBI