DDX59 - DEAD-box helicase 59 Gene

Also Known as OFD5; ZNHIT5

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 83479

About DDX59

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:200,640,805-200,669,907 (from NCBI)

This gene has 8 transcripts (splice variants), 187 orthologues, 38 paralogues and is associated with 3 phenotypes. Ubiquitous expression in bone marrow (RPKM 2.6), thyroid (RPKM 2.3) and 25 other tissues.

Summary

Predicted to enable RNA binding activity and RNA helicase activity. Predicted to be located in cytoplasm and nucleus. Predicted to be integral component of membrane. Implicated in orofaciodigital syndrome V. [provided by Alliance of Genome Resources, Apr 2022]

DDX59 Products (9)

mRNA Protein Name
NM_001031725.6 NP_001026895.2 probable ATP-dependent RNA helicase DDX59 isoform 1
NM_001320181.2 NP_001307110.1 probable ATP-dependent RNA helicase DDX59 isoform 2
NM_001320182.1 NP_001307111.1 probable ATP-dependent RNA helicase DDX59 isoform 3
NM_001349799.3 NP_001336728.1 probable ATP-dependent RNA helicase DDX59 isoform 1
NM_001349800.3 NP_001336729.1 probable ATP-dependent RNA helicase DDX59 isoform 1
NM_001349801.3 NP_001336730.1 probable ATP-dependent RNA helicase DDX59 isoform 4
NM_001349802.3 NP_001336731.1 probable ATP-dependent RNA helicase DDX59 isoform 5
NM_001349803.3 NP_001336732.1 probable ATP-dependent RNA helicase DDX59 isoform 6
NM_001349804.2 NP_001336733.1 probable ATP-dependent RNA helicase DDX59 isoform 7

DDX59 Protein Structure

zf-HIT

zf-HIT: HIT zinc finger (106 - 132)

DEAD

DEAD: DEAD/DEAH box helicase (227 - 393)

Helicase_C

Helicase_C: Helicase conserved C-terminal domain (468 - 540)

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  • 619 a.a.
Protein Preferred Names Protein Names

probable ATP-dependent RNA helicase DDX59

  • DEAD (Asp-Glu-Ala-Asp) box polypeptide 59

関連疾患

Diseases Alias
Orofaciodigital Syndrome V

  • OFD5

  • Thurston Syndrome

  • Orofaciodigital Syndrome 5

  • Polydactyly, Postaxial, With Median Cleft Of Upper Lip

  • Ofds V

  • Oral-Facial-Digital Syndrome, Type V

  • Orofaciodigital Syndrome, Thurston Type

  • Orofaciodigital Syndrome Thurston Type

  • Oral-Facial-Digital Syndrome 5

  • Polydactyly Postaxial With Median Cleft Of Upper Lip

  • Ofd Syndrome 5

  • Ofds 5

  • Oral Facial Digital Syndrome 5

  • Oral Facial Digital Syndrome Type 5

  • Orofaciodigital Syndrome Type 5

  • Oral-Facial-Digital Syndrome Type 5

  • Papillon-Leage And Psaume Syndrome

  • Orofaciodigital Syndrome, Type V
Orofaciodigital Syndrome

  • Oral-Facial-Digital Syndrome

  • Orofaciodigital Syndromes

  • Ofd

  • Oral Facial Digital Syndromes

  • Oral-Facial-Digital Syndromes

  • Dysplasia Linguofacialis

  • Ofds

  • Oro-Facio-Digital Syndrome

  • Orodigitofacial Dysostosis

  • Orodigitofacial Syndrome

  • Oral Facial Digital Syndrome

  • Orofaciodigital Syndrome I
Chromosome 1q21.1 Duplication Syndrome

  • 1q21.1 Microduplication Syndrome

  • Trisomy 1q21.1

  • 1q21.1 Duplication Syndrome

  • 1q21.1 Microduplication

  • 1q21.1 Duplication

  • Dup(1)(Q21.1)
Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome 1

  • Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome

  • Berdon Syndrome

  • MMIHS

  • Megacystis Microcolon Intestinal Hypoperistalsis Syndrome

  • Megacystis, Microcolon, Hypoperistalsis Syndrome

  • Visceral Myopathy

  • Mmih Syndrome

  • Megacystis-Microcolon-Intestinal Hypoperistalsis-Hydronephrosis Syndrome

  • MMIHS1

  • Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome, Mmih

  • Mmhs
Orofaciodigital Syndrome Vi

  • OFD6

  • Varadi-Papp Syndrome

  • Varadi Syndrome

  • Joubert Syndrome With Orofaciodigital Defect

  • Orofaciodigital Syndrome Type 6

  • Orofaciodigital Syndrome 6

  • Oral-Facial-Digital Syndrome, Type Vi

  • Ofds Vi

  • Polydactyly, Cleft Lip/Palate Or Lingual Lump, And Psychomotor Retardation

  • Polydactyly Cleft Lip Palate Psychomotor Retardation

  • Oral-Facial-Digital Syndrome Type 6

  • Polydactyly-Cleft Lip/Palate-Psychomotor Retardation Syndrome

  • Polydactyly - Cleft Lip/Palate - Psychomotor Retardation

  • Váradi Syndrome

  • Váradi-Papp Syndrome

  • Joubert Syndrome With Oral-Facial-Digital Syndrome

  • Oral-Facial-Digital Syndrome 6

  • Joubert-Orofaciodigital Syndrome

  • Orofaciodigital Syndrome, Type Vi
Congenital Nervous System Abnormality

  • Congenital Neurologic Anomaly

  • Congenital Nervous System Disorder
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS03662 DDX59 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Mus musculus DDX59 MGD MGI:1915247
Bos taurus DDX59 VGNC VGNC:27980
Macaca mulatta DDX59 VGNC VGNC:99882
Felis catus DDX59 VGNC VGNC:61419
Canis familiaris DDX59 VGNC VGNC:39868
Rattus norvegicus DDX59 RGD RGD:1359520
Others DDX59 NCBI