ACSS1 - acyl-CoA synthetase short chain family member 1 Gene

Also Known as ACAS2L; ACECS1; AceCS2L

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 84532

About ACSS1

Cytogenetic location: 20p11.21 Genomic coordinates (GRCh38): 20:25,006,237-25,058,139 (from NCBI)

This gene has 5 transcripts (splice variants), 188 orthologues and 13 paralogues. Broad expression in placenta (RPKM 70.4), duodenum (RPKM 23.0) and 24 other tissues.

Summary

This gene encodes a mitochondrial Acetyl-CoA synthetase enzyme. A similar protein in mice plays an important role in the Tricarboxylic Acid Cycle by catalyzing the conversion of acetate to acetyl CoA. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

ACSS1 Products (4)

mRNA Protein Name
NM_001252675.2 NP_001239604.1 acetyl-coenzyme A synthetase 2-like, mitochondrial isoform 2 precursor
NM_001252676.2 NP_001239605.1 acetyl-coenzyme A synthetase 2-like, mitochondrial isoform 3
NM_001252677.2 NP_001239606.1 acetyl-coenzyme A synthetase 2-like, mitochondrial isoform 4 precursor
NM_032501.4 NP_115890.2 acetyl-coenzyme A synthetase 2-like, mitochondrial isoform 1 precursor

ACSS1 Protein Structure

AMP-binding

AMP-binding: AMP-binding enzyme (116 - 556)

AMP-binding_C

AMP-binding_C: AMP-binding enzyme C-terminal domain (564 - 642)

  • 0
  • 200
  • 400
  • 600
  • 689 a.a.
Protein Preferred Names Protein Names

acetyl-coenzyme A synthetase 2-like, mitochondrial

  • acetate--CoA ligase 2

ACSS1 Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
ACSS1 Q9NUB1 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra
ACSS1 Q9NUB1 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra
ACSS1 Q9NUB1 VAC14 Homo sapiens Q08AM6
Y2H Prey Pooling
32296183
Intra
ACSS1 Q9NUB1 VAC14 Homo sapiens Q08AM6
Y2H Array
32296183
Intra
ACSS1 Q9NUB1 VAC14 Homo sapiens Q08AM6
Validated Y2H
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ACSS1 Proteins

製品番号 製品名 アクセッション番号 純度
HY-P71851 ACSS1 Protein, Human (P.pastoris, His) Q9NUB1-1 (A38-K689) ≥ 90%, as determined by reducing SDS-PAGE.

ACSS1 抗体

製品番号 製品名 アプリケーション 反応性
HY-P84828 ACSS1 Antibody (YA4525) WB, ELISA Human
HY-P84828A ACSS1 Antibody (YA4525)(PBS only) WB, ELISA Human
HY-P84829 ACSS1 Antibody (YA4526) IHC-P, FC, ELISA Human
HY-P84829A ACSS1 Antibody (YA4526)(PBS only) IHC-P, FC, ELISA Human

関連疾患

Diseases Alias
Cardiomyopathy, Infantile Histiocytoid

  • Histiocytoid Cardiomyopathy

  • Foamy Myocardial Transformation Of Infancy

  • Infantile Histiocytoid Cardiomyopathy

  • Infantile Xanthomatous Cardiomyopathy

  • Oncocytic Cardiomyopathy

  • Cardiomyopathy, Infantile Xanthomatous

  • Cardiomyopathy, Focal Lipid

  • Cardiomyopathy, Oncocytic

  • Focal Lipid Cardiomyopathy

  • Infantile Cardiomyopathy With Histiocytoid Change

  • CMIH

  • Cardiomyopathy Focal Lipid

  • Cardiomyopathy Infantile Xanthomatous

  • Cardiomyopathy Oncocytic
Canavan Disease

  • Aspartoacylase Deficiency

  • Aminoacylase 2 Deficiency

  • Spongy Degeneration Of Central Nervous System

  • Aspa Deficiency

  • Acy2 Deficiency

  • Canavan-Van Bogaert-Bertrand Disease

  • Mild Canavan Disease

  • Asp Deficiency

  • Spongy Degeneration Of The Central Nervous System

  • Severe Canavan Disease

  • Von Bogaert-Bertrand Disease

  • Canavan'S Disease

  • Spongy Degeneration Of The Brain

  • Juvenile Canavan Disease

  • Infantile Canavan Disease

  • Neonatal Canavan Disease

  • CAND

  • Disease, Canavan

  • Canavan Disease, Juvenile

  • Canavan Disease, Infantile

  • Canavan Disease, Neonatal
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-145953 VY-3-135 Inhibitor 99.62% Unkown
HY-RS00210 ACSS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18053 Acss1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24528 Acss1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Rattus norvegicus ACSS1 RGD RGD:1306246
Macaca mulatta ACSS1 VGNC VGNC:69416
Canis familiaris ACSS1 VGNC VGNC:52863
Bos taurus ACSS1 VGNC VGNC:25570
Mus musculus ACSS1 MGD MGI:1915988
Felis catus ACSS1 VGNC VGNC:82636
Others ACSS1 NCBI