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GOSR1 - golgi SNAP receptor complex member 1 Gene

Also Known as P28; GS28; GOS28; GOLIM2; GOS-28; GOS28/P28

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 9527

About GOSR1

Cytogenetic location: 17q11.2 Genomic coordinates (GRCh38): 17:30,477,408-30,527,592 (from NCBI)

This gene has 12 transcripts (splice variants) and 253 orthologues. Ubiquitous expression in thyroid (RPKM 7.3), kidney (RPKM 5.6) and 25 other tissues.

Summary

This gene encodes a trafficking membrane protein which transports proteins among the endoplasmic reticulum and the Golgi and between Golgi compartments. This protein is considered an essential component of the Golgi SNAP receptor (SNARE) complex. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GOSR1 Products (3)

mRNA	Protein	Name
NM_001007024.2	NP_001007025.1	Golgi SNAP receptor complex member 1 isoform 3
NM_001007025.2	NP_001007026.1	Golgi SNAP receptor complex member 1 isoform 2
NM_004871.3	NP_004862.1	Golgi SNAP receptor complex member 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	参考文献	由来
enables SNAP receptor activity	IDA IDA: Inferred from direct assay	15215310	GOA

Biological Process GO Annotation	Evidence	参考文献	由来
involved in retrograde transport, endosome to Golgi	IDA IDA: Inferred from direct assay	15215310	GOA

Cellular Component GO Annotation	Evidence	参考文献	由来
located in Golgi apparatus	IDA IDA: Inferred from direct assay	9464276	GOA
located in Golgi membrane	IDA IDA: Inferred from direct assay	21669198	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GOSR1 Protein Structure

V-SNARE_C

0
100
200
250 a.a.

Protein Preferred Names	Protein Names
Golgi SNAP receptor complex member 1	28 kDa Golgi SNARE protein

関連疾患

Diseases	Alias
Congenital Disorder Of Glycosylation, Type Iig	CDG2G Congenital Disorder Of Glycosylation Type Iig Cdg Iig Cdgiig Cdgii/Cog1 Cerebrocostomandibular-Like Syndrome Carbohydrate Deficient Glycoprotein Syndrome Type Iig Cdg-Iig Congenital Disorder Of Glycosylation, Type 2g Cog1-Cdg Cdg Syndrome Type Iig Congenital Disorder Of Glycosylation Type 2g Congenital Disorder Of Glycosylation 2g Cdg-Ii Caused By Cog1 Deficiency Glycosylation, Congenital Disorder Of, Type Iig
Griscelli Syndrome, Type 3	Griscelli Syndrome Type 3 GS3 Griscelli-Prunieras Syndrome Type 3 Hypomelanosis With No Immunologic Or Neurologic Manifestations Griscelli Syndrome 3
Congenital Disorder Of Glycosylation, Type Iih	CDG2H Congenital Disorder Of Glycosylation Type Iih Cdg Iih Cdgiih Carbohydrate Deficient Glycoprotein Syndrome Type Iih Congenital Disorder Of Glycosylation Type 2h Cog8-Cdg Cdg-Iih Cdgiidh Cdg Syndrome Type Iih Congenital Disorder Of Glycosylation 2h Glycosylation, Congenital Disorder Of, Type Iih
Immunodeficiency 47	Congenital Disorder Of Glycosylation Type Ii CDG2E Congenital Disorder Of Glycosylation Type Iie IMD47 Cdg2s Cdg Iis Cdgiis Immunodeficiency And Hepatopathy With Or Without Neurologic Features Congenital Disorder Of Glycosylation, Type Ii CDG1I Congenital Disorder Of Glycosylation, Type Iie Cdg Iie Congenital Disorder Of Glycosylation Type 2e Congenital Disorder Of Glycosylation, Type Iis Cdg Ii Cdgii Cdgiie Carbohydrate Deficient Glycoprotein Syndrome Type Iie Cdg Syndrome Type Iie Congenital Disorder Of Glycosylation Ii Congenital Disorder Of Glycosylation 1i Cdg-Iie Alg2-Cdg Cdg-Ii Glycosylation, Congenital Disorder Of, Type Ii Cdgiide Congenital Disorder Of Glycosylation Type Iis Cog7-Cdg Cdg Syndrome Type Ii Carbohydrate Deficient Glycoprotein Syndrome Type Ii Congenital Disorder Of Glycosylation Type 1i Mannosyltransferase 2 Deficiency Congenital Disorder Of Glycosylation 2e Congenital Disorder Of Glycosylation 2s Congenital Disorders Of Glycosylation Type Ii Glycosylation, Congenital Disorder Of, Type Iie Immunodeficiency, Type 47 Congenital Disorder Of Glycosylation Type 2a
Congenital Disorder Of Glycosylation, Type In	Congenital Disorder Of Glycosylation CDG1N Congenital Disorders Of Glycosylation Cdg In Cdgin Congenital Disorder Of Glycosylation 1n Carbohydrate-Deficient Glycoprotein Syndrome Cdg Rft1-Cdg Cdg-In Congenital Disorder Of Glycosylation Type In Carbohydrate Deficient Glycoprotein Syndrome Cdg Syndrome Congenital Disorder Of Glycosylation In Carbohydrate-Deficient Glycoprotein Syndromes Cdg Syndrome Type In Carbohydrate Deficient Glycoprotein Syndrome Type In Congenital Disorder Of Glycosylation Type 1n Man5glcnac2-Pp-Dol Flippase Deficiency Glycosylation, Congenital Disorder Of Glycosylation, Congenital Disorder Of, Type In

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-RS05603	GOSR1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Canis familiaris	GOSR1	VGNC	VGNC:41353
Macaca mulatta	GOSR1	VGNC	VGNC:73110
Mus musculus	GOSR1	MGD	MGI:1858260
Bos taurus	GOSR1	VGNC	VGNC:29500
Rattus norvegicus	GOSR1	RGD	RGD:71093
Others	GOSR1	NCBI