Ilicicolin A
Ilicicolin A is a potent anticancer agent. Ilicicolin A induces apoptosis. Ilicicolin A inhibits cell growth and colony formation. Ilicicolin A shows antitumor activity. Ilicicolin A has the potential for the research of prostate cancer.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 22581-06-2
- 分子式: C23H31ClO3
- 分子量:390.94
-
保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
生物活性
Ilicicolin A (0, 2.5, 5, 10 µM; 48 h) induces apoptosis in 22Rv1, C4-2B cells[1].
Ilicicolin A (0, 2.5, 5, 10 µM) inhibits cell growth and colony formation in 22Rv1 cells and C4-2B cells in a dose-dependent manner[1].
Ilicicolin A (0, 2.5, 5, 10 µM; 48 h) decreases the protein expression of EZH2, AURKA, PLK1, FoxM1, Cyclin B2, AR, c-Myc, cyclin D1[1].
Ilicicolin A (0, 2.5, 5, 10 µM; 48 h) decreases the mRNA expression of AR, ALK2, ALK3 in a dose-dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:22Rv1, C4-2B cells
-
Concentration:0, 2.5, 5, 10 µM
-
Incubation Time:96 h
-
Result:Inhibited cell growth in a dose-dependent manner.
-
Cell Line:22Rv1, C4-2B cells
-
Concentration:0, 2.5, 5, 10 µM
-
Incubation Time:48 h
-
Result:Induced apoptosis and increased the expression of cleaved-PARP1 and cleaved caspase 7.
-
Cell Line:22Rv1, C4-2B cells
-
Concentration:0, 2.5, 5, 10 µM
-
Incubation Time:48 h
-
Result:Decreased the expression of EZH2, AURKA, PLK1, FoxM1, Cyclin B2, AR, c-Myc, cyclin D1.
-
Cell Line:22Rv1, C4-2B cells
-
Concentration:0, 2.5, 5, 10 µM
-
Incubation Time:48 h
-
Result:Decreased the mRNA expression of AR, ALK2, ALK3 in a dose-dependent manner.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Four-week-old, 18 g, male NOD/SCID mice (22Rv1 cells) [1]
-
Dosage:10 mg/kg
-
Administration:I.p.; six times a week for 3 weeks
-
Result:Suppressed tumor growth but did not elicit a significant effect on bodyweight.
化学情報
-
CAS 番号 22581-06-2
-
分子量 390.94
-
分子式 C23H31ClO3
-
SMILES
O=CC1=C(C(C/C=C(CC/C=C(CC/C=C(C)\C)\C)\C)=C(C(Cl)=C1C)O)O
-
別名
LL-Z 1272-alpha
-
Structure Classification
-
Initial Source
Fusarium sp.
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Ilicicolin A 関連分類
HY-122108 関連分類
Powered by Bioz