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United States

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製品番号: HY-183773

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KOR agonist-9

KOR agonist-9 is a selective kappa opioid receptor (KOR) agonist with an EC₅₀of 1.41 nM. KOR agonist-9 exhibits >125-fold selectivity over μ/δ-opioid receptors. KOR agonist-9 antinociceptive and antipruritic effects in mice. KOR agonist-9 can be used for the research of pain, pruritus.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

分子式: C₃₆H₄₅N₃O₄
分子量:583.76

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

KOR agonist-9 構造式

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
- 体内実験
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
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生物活性

製品説明

IC₅₀ & Target

^[1]

κ Opioid Receptor/KOR

0.0016 nM (Ki)

κ Opioid Receptor/KOR

1.41 nM (EC₅₀)

μ Opioid Receptor/MOR

0.20 nM (Ki)

δ Opioid Receptor/DOR

15.15 nM (Ki)

Opioid Receptor アイソフォーム固有の製品をすべて表示 :

体外実験

KOR agonist-9 (compound 10e) (17 h) shows significantly lower potency for β-arrestin recruitment in HTLA-KOR Tango cells (EC₅₀ = 4912 nM) compared to cAMP inhibition, indicating G-protein biased signaling^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

KOR agonist-9 (compound 10e) (2-20 mg/kg; i.p.; single dose; 4 hours pretreatment) induces dose-dependent antinociception in the mouse acetic acid-induced writhing visceral nociception model^[1].
KOR agonist-9 (5-10 mg/kg; i.p.; single dose; 4 hours pretreatment) induces dose-dependent antipruritic effects in the mouse histamine-induced pruritus model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

ICR mice (male, 18~22 g)^[1]
Dosage:

2; 5; 10; 15; 20 mg/kg
Administration:

i.p.; single dose; 4 hours pretreatment
Result:

Produced dose-dependent antinociceptive effects.
Showed significant antinociception observed at the 15 mg/kg dose.

Animal Model:

ICR mice (male, 18~22 g)^[1]
Dosage:

5; 10 mg/kg
Administration:

i.p.; single dose; 4 hours pretreatment
Result:

Elicited dose-dependent antipruritic activity.
Showed a significant reduction in scratching bouts observed at the 10 mg/kg dose.

化学情報

分子量 583.76
分子式 C₃₆H₄₅N₃O₄
SMILES

COC1=C(O2)C([C@]([C@@H]2[C@]3(OC)[C@@H](N4CCN(C(CC5=CC=CC=C5)=O)CC4)C6)(CC7)[C@@]6(CC3)C(N7CC8CC8)C9)=C9C=C1
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Duan S, et al. Discovery of a highly selective and potent kappa opioid receptor agonist from N-cyclopropylmethyl-7α-piperazinyl -6,14-endoethano-tetrahydronorthebaines. Eur J Med Chem. 2026 May 16;315:118964. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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