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製品番号: HY-184099

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Zinilisib

Name: Zinilisib
Brand: MedChemExpress
SKU: HY-184099
Availability: PreOrder

(別名: zinilisibum)

Zinilisib (Zinilisibum) is a PI3K inhibitor. Zinilisib potently inhibits the phosphorylation of AKT in cells expressing mutant PI3Kα^H1047R and wild-type PI3Kα, with IC₅₀ values of 1-500 nM and 2-15 μM, respectively. Zinilisib can be used in breast cancer-related research.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 3031974-57-6
分子式: C₂₆H₂₉F₃N₄O₃
分子量:502.53

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Zinilisib 構造式

CAS 番号: 3031974-57-6

容量

価格（税別）

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

PI3K アイソフォーム固有の製品をすべて表示 :

Akt アイソフォーム固有の製品をすべて表示 :

体外実験

Anti-cancerOncogenic Signaling (PI3K, MAPK, Wnt, JAK-STAT)

Anti-cancer

Zinilisib (Example 8) potently inhibits the proliferation of T47D cells expressing mutant PI3Kα^H1047R, with a mean EC₅₀ ranging from 1 nM to 500 nM; it also inhibits the proliferation of SKBR3 cells expressing wild-type PI3Kα, with a mean EC₅₀ ranging from 2 μM to 15 μM^[2].

Anti-cancer

Oncogenic Signaling (PI3K, MAPK, Wnt, JAK-STAT)

Zinilisib (6 h) potently inhibits AKT phosphorylation in T47D cells expressing mutant PI3Kα^H1047R, with a mean IC₅₀ ranging from 1 nM to 500 nM; it also inhibits AKT phosphorylation in SKBR3 cells expressing wild-type PI3Kα, with a mean IC₅₀ ranging from 2 μM to 15 μM^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[2]

Cell Line:

T47D cells expressing mutant PI3Kα (H1047R), SKBR3 cells expressing wild-type PI3Kα
Concentration:

10-point dilution series
Incubation Time:

72 h
Result:

Inhibited proliferation of T47D cells with an average EC₅₀ in the range of 1 nM to 500 nM.
Inhibited proliferation of SKBR3 cells with an average EC₅₀ in the range of 2 μM to 15 μM.

Related Protocols :

化学情報

CAS 番号 3031974-57-6
分子量 502.53
分子式 C₂₆H₂₉F₃N₄O₃
SMILES

OC(C(C=CC=C1)=C1N[C@@H](C2=C3C(C(N(C(N4CCN(CC4)CC(F)(F)F)=C3)C)=O)=CC(C)=C2)C)=O
別名

zinilisibum
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. International Nonproprietary
Names for Pharmaceutical
Substances (INN). WHO Drug Information, Vol. 39, No. 4, 2025.

[2]. James F, et al. Isoquinolones as pi3k inhibitors. WO2024054469A1. WIPO (PCT). 2023-09-06.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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生物活性
- 製品説明
- 体外実験
化学情報
純度とドキュメンテーション
参考文献

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Zinilisib

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