Kalopanaxsaponin H
Kalopanaxsaponin H is an hederagenin glycoside (saponin) with no hypoglycemic activity upon intraperitoneal injection. Kalopanaxsaponin H can be metabolized by human intestinal bacteria into Kalopanaxsaponin I, Kalopanaxsaponin A, hederagenin 3-O-α-L-arabinopyranoside and hederagenin, among which Kalopanaxsaponin I and hederagenin are the main metabolites. Kalopanaxsaponin H is isolated from the stem bark of Kalopanax pictus and is used in diabetes-related research.
For research use only. We do not sell to patients.
- CAS No.: 119742-55-1
- Formula: C64H104O30
- Molecular Weight:1353.49
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HepG2 | IC50 |
0.6 μM
Compound: 11
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Inhibition of TNF-alpha-induced NFkappaB activation in human HepG2 cells after 1 hr by luciferase reporter assay
Inhibition of TNF-alpha-induced NFkappaB activation in human HepG2 cells after 1 hr by luciferase reporter assay
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[PMID: 21870831] |
Kalopanaxsaponin H (0.4 mg/mL; 6-36 h) is metabolized by human fecal intestinal bacteria primarily to kalopanaxsaponin I and hederagenin, with additional minor metabolites kalopanaxsaponin A and hederagenin 3-O-α-L-arabinopyranoside, over incubation periods of 6 to 36 h at 37°C[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Sprague-Dawley (male, 200-250 g, streptozotocin-induced)[1]
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Dosage:25 mg/kg
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Administration:i.p.; daily; 3 days
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Result:Exhibited serum glucose level of 320.8 ± 54.21 mg/dl.
Exhibited serum total lipid level of 339.6 ± 38.74 mg/dl.
Exhibited serum triglyceride level of 119.8 ± 13.25 mg/dl.
Exhibited serum total cholesterol level of 116.9 ± 15.3 mg/dl.
Exhibited serum HDL cholesterol level of 21.7 ± 2.99 mg/dl.
Exhibited serum VLDL+LDL cholesterol level of 108.0 ± 17.1 mg/dl.
Showed levels comparable to untreated diabetic rats.
Chemical Information
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CAS No. 119742-55-1
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Molecular Weight 1353.49
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Formula C64H104O30
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SMILES
OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2[C@@H]([C@@H]([C@H]([C@@H](O2)C)O)O)O)O[C@H]1OC[C@H]([C@H]([C@@H]([C@H]3O)O)O)O[C@H]3OC([C@]45[C@](CC(C)(CC5)C)([H])C6=CC[C@@]([C@@]7([C@@]([C@@](C)([C@H](CC7)O[C@H]8[C@@H]([C@H]([C@H](CO8)O)O)O[C@H]9[C@@H]([C@@H]([C@H]([C@@H](O9)C)O)O[C@H]%10[C@@H]([C@H]([C@@H](CO%10)O)O)O)O)CO)([H])CC%11)C)([H])[C@]%11(C)[C@@]6(CC4)C)=O
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Kalopanaxsaponin H Related Classifications
HY-N17985 Related Classifications
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