2. Productos naturales
  3. Plants Terpenoids
  4. Araliaceae Pentacyclic Triterpenoids
  5. Kalopanax septemlobus (Thunb.) Koidz.
  6. Kalopanaxsaponin H

Kalopanaxsaponin H is an hederagenin glycoside (saponin) with no hypoglycemic activity upon intraperitoneal injection. Kalopanaxsaponin H can be metabolized by human intestinal bacteria into Kalopanaxsaponin I, Kalopanaxsaponin A, hederagenin 3-O-α-L-arabinopyranoside and hederagenin, among which Kalopanaxsaponin I and hederagenin are the main metabolites. Kalopanaxsaponin H is isolated from the stem bark of Kalopanax pictus and is used in diabetes-related research.

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Kalopanaxsaponin H

Kalopanaxsaponin H Estructura química

No. CAS : 119742-55-1

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Kalopanaxsaponin H Related Antibodies

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Descripciòn

Kalopanaxsaponin H is an hederagenin glycoside (saponin) with no hypoglycemic activity upon intraperitoneal injection. Kalopanaxsaponin H can be metabolized by human intestinal bacteria into Kalopanaxsaponin I, Kalopanaxsaponin A, hederagenin 3-O-α-L-arabinopyranoside and hederagenin, among which Kalopanaxsaponin I and hederagenin are the main metabolites. Kalopanaxsaponin H is isolated from the stem bark of Kalopanax pictus and is used in diabetes-related research[1].

In Vitro

Kalopanaxsaponin H (0.4 mg/mL; 6-36 h) is metabolized by human fecal intestinal bacteria primarily to kalopanaxsaponin I and hederagenin, with additional minor metabolites kalopanaxsaponin A and hederagenin 3-O-α-L-arabinopyranoside, over incubation periods of 6 to 36 h at 37°C[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Kalopanaxsaponin H Related Antibodies
In Vivo

Kalopanaxsaponin H (25 mg/kg; i.p.; daily; 3 days) shows no antidiabetic activity in streptozotocin-induced diabetic Sprague-Dawley rats, with serum glucose, lipid, and cholesterol levels comparable to untreated diabetic rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague-Dawley (male, 200-250 g, streptozotocin-induced)[1]
Dosage: 25 mg/kg
Administration: i.p.; daily; 3 days
Result: Exhibited serum glucose level of 320.8 ± 54.21 mg/dl.
Exhibited serum total lipid level of 339.6 ± 38.74 mg/dl.
Exhibited serum triglyceride level of 119.8 ± 13.25 mg/dl.
Exhibited serum total cholesterol level of 116.9 ± 15.3 mg/dl.
Exhibited serum HDL cholesterol level of 21.7 ± 2.99 mg/dl.
Exhibited serum VLDL+LDL cholesterol level of 108.0 ± 17.1 mg/dl.
Showed levels comparable to untreated diabetic rats.
Peso molecular

1353.49

Fòrmula

C64H104O30
No. CAS
SMILES

OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2[C@@H]([C@@H]([C@H]([C@@H](O2)C)O)O)O)O[C@H]1OC[C@H]([C@H]([C@@H]([C@H]3O)O)O)O[C@H]3OC([C@]45[C@](CC(C)(CC5)C)([H])C6=CC[C@@]([C@@]7([C@@]([C@@](C)([C@H](CC7)O[C@H]8[C@@H]([C@H]([C@H](CO8)O)O)O[C@H]9[C@@H]([C@@H]([C@H]([C@@H](O9)C)O)O[C@H]%10[C@@H]([C@H]([C@@H](CO%10)O)O)O)O)CO)([H])CC%11)C)([H])[C@]%11(C)[C@@]6(CC4)C)=O
Structure Classification
Initial Source
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

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Kalopanaxsaponin H Related Classifications

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Keywords:

Kalopanaxsaponin H119742-55-1Othersdiabeteshuman intestinal bacteriasaponinhederagenin glycosidekalopanaxsaponin Ahederagenin 3-O-α-L-arabinopyranosidestreptozotocin-induced diabetic Sprague-Dawley ratskalopanaxsaponin IKalopanax pictushederageninInhibitorinhibitorinhibit

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Nombre del producto:
Kalopanaxsaponin H
Cat. No.:
HY-N17985
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