2. Natural Products
  3. Plants Terpenoids
  4. Araliaceae Pentacyclic Triterpenoids
  5. Kalopanax septemlobus (Thunb.) Koidz.
  6. Kalopanaxsaponin H

Kalopanaxsaponin H is an hederagenin glycoside (saponin) with no hypoglycemic activity upon intraperitoneal injection. Kalopanaxsaponin H can be metabolized by human intestinal bacteria into Kalopanaxsaponin I, Kalopanaxsaponin A, hederagenin 3-O-α-L-arabinopyranoside and hederagenin, among which Kalopanaxsaponin I and hederagenin are the main metabolites. Kalopanaxsaponin H is isolated from the stem bark of Kalopanax pictus and is used in diabetes-related research.

For research use only. We do not sell to patients.

Kalopanaxsaponin H

Kalopanaxsaponin H Chemical Structure

CAS No. : 119742-55-1

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Kalopanaxsaponin H Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Kalopanaxsaponin H is an hederagenin glycoside (saponin) with no hypoglycemic activity upon intraperitoneal injection. Kalopanaxsaponin H can be metabolized by human intestinal bacteria into Kalopanaxsaponin I, Kalopanaxsaponin A, hederagenin 3-O-α-L-arabinopyranoside and hederagenin, among which Kalopanaxsaponin I and hederagenin are the main metabolites. Kalopanaxsaponin H is isolated from the stem bark of Kalopanax pictus and is used in diabetes-related research[1].

In Vitro

Kalopanaxsaponin H (0.4 mg/mL; 6-36 h) is metabolized by human fecal intestinal bacteria primarily to kalopanaxsaponin I and hederagenin, with additional minor metabolites kalopanaxsaponin A and hederagenin 3-O-α-L-arabinopyranoside, over incubation periods of 6 to 36 h at 37°C[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Kalopanaxsaponin H Related Antibodies
In Vivo

Kalopanaxsaponin H (25 mg/kg; i.p.; daily; 3 days) shows no antidiabetic activity in streptozotocin-induced diabetic Sprague-Dawley rats, with serum glucose, lipid, and cholesterol levels comparable to untreated diabetic rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague-Dawley (male, 200-250 g, streptozotocin-induced)[1]
Dosage: 25 mg/kg
Administration: i.p.; daily; 3 days
Result: Exhibited serum glucose level of 320.8 ± 54.21 mg/dl.
Exhibited serum total lipid level of 339.6 ± 38.74 mg/dl.
Exhibited serum triglyceride level of 119.8 ± 13.25 mg/dl.
Exhibited serum total cholesterol level of 116.9 ± 15.3 mg/dl.
Exhibited serum HDL cholesterol level of 21.7 ± 2.99 mg/dl.
Exhibited serum VLDL+LDL cholesterol level of 108.0 ± 17.1 mg/dl.
Showed levels comparable to untreated diabetic rats.
Molecular Weight

1353.49

Formula

C64H104O30
CAS No.
SMILES

OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2[C@@H]([C@@H]([C@H]([C@@H](O2)C)O)O)O)O[C@H]1OC[C@H]([C@H]([C@@H]([C@H]3O)O)O)O[C@H]3OC([C@]45[C@](CC(C)(CC5)C)([H])C6=CC[C@@]([C@@]7([C@@]([C@@](C)([C@H](CC7)O[C@H]8[C@@H]([C@H]([C@H](CO8)O)O)O[C@H]9[C@@H]([C@@H]([C@H]([C@@H](O9)C)O)O[C@H]%10[C@@H]([C@H]([C@@H](CO%10)O)O)O)O)CO)([H])CC%11)C)([H])[C@]%11(C)[C@@]6(CC4)C)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Kalopanaxsaponin H Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Kalopanaxsaponin H119742-55-1Othersdiabeteshuman intestinal bacteriasaponinhederagenin glycosidekalopanaxsaponin Ahederagenin 3-O-α-L-arabinopyranosidestreptozotocin-induced diabetic Sprague-Dawley ratskalopanaxsaponin IKalopanax pictushederageninInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Kalopanaxsaponin H
Cat. No.:
HY-N17985
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.