L-783277
L-783277 (Compound 4) is a MEK inhibitor (IC50 = 4 nM). L-783277 has potent inhibitory activity against a variety of kinases, including VEGFR2/3, FLT1/3/4, MEK1/2, KDR, and PDGFRα, but has low selectivity for the kinase community. L-783277 inhibits viability (IC50 = 22 mM) and cell proliferation (IC50 = 21 mM) of H295R cells. L-783277 could be used in research on cancers such as adrenocortical carcinoma.
For research use only. We do not sell to patients.
- CAS No.: 791807-02-8
- Formula: C19H24O7
- Molecular Weight:364.39
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MV4-11 | IC50 |
0.01 μM
Compound: L783277
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Antiproliferative activity against human MV4-11 cells after 72 hrs by luminescent cell viability assay
Antiproliferative activity against human MV4-11 cells after 72 hrs by luminescent cell viability assay
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[PMID: 25456387] |
| THP-1 | IC50 |
1.18 μM
Compound: L783277
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Antiproliferative activity against human THP1 cells after 72 hrs by luminescent cell viability assay
Antiproliferative activity against human THP1 cells after 72 hrs by luminescent cell viability assay
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[PMID: 25456387] |
Chemical Information
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CAS No. 791807-02-8
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Molecular Weight 364.39
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Formula C19H24O7
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SMILES
O=C(O[C@@H](C)C/C=C\1)C2=C(O)C=C(OC)C=C2CCC[C@H](O)[C@H](O)C1=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Kim Y, et al. Natural and Synthetic Lactones Possessing Antitumor Activities. Int J Mol Sci. 2021 Jan 21;22(3):1052. [Content Brief]
[2]. Lawnicka H, et al. Resorcylic acid lactone L-783,277 inhibits the growth of the human adrenal cancer cell line H295R in vitro. Int J Immunopathol Pharmacol. 2009 Oct-Dec;22(4):889-95. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
L-783277 Related Classifications
HY-123586 Related Classifications
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