Cefditoren Pivoxil
Based on 1 Customer Validation
Cefditoren Pivoxil (ME 1207) is a broad-spectrum, third-generation, oral cephalosporin antibacterial with enhanced stability against many common β lactamases. Cefditoren Pivoxil has activity against Gram-negative organisms and Gram-positive organisms. Cefditoren Pivoxil can be used in the research of infection diseases such as acute exacerbations of chronic bronchitis, community-acquired pneumonia (CAP), streptococcal pharyngitis/tonsillitis, or uncomplicated skin and skin structure infections.
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- Purity: 99.29%
- CAS No.: 117467-28-4
- 화학식: C25H28N6O7S3
- 분자량:620.72
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보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
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Biological Activity
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β-lactam |
Cefditoren Pivoxil shows good activity against pneumoniae, S. pyogenes, Staphylococcus aureus, H. influenzae and H. parainfluenzae, M. catarrhalis[1].
| Organism | MIC50 (mg/L) | MIC90 (mg/L) | susceptible (%) |
| Gram-positive organisms | |||
| Streptococcus pneumoniae (untyped)a |
0.015-0.25 | 0.12-1 | |
| PS | ≤0.008-0.03 | 0.015-0.25 | 99-100 |
| PI | 0.06-0.5 | 0.25-0.5 | 94-100 |
| PR | 0.25-1 | 0.5-2 | 7-100 |
| S. pyogenes | ≤0.008-0.03 | 0.015-0.03 | 100 |
| Staphylococcus aureus (MS) | 0.12-0.5 | 0.5-1 | 50-100 |
| Gram-negative organisms | |||
| Haemophilus | ≤0.008-≤0.03 | 0.015-0.13 | |
| influenzae (untyped)b | |||
| β-Lactamase + | ≤0.008-0.03 | 0.015-0.06 | 100 |
| β-Lactamase - | ≤0.008-0.03 | 0.015-0.06 | 100 |
| H. parainfluenzaeb | ≤0.03 | 0.06 | |
| Moraxella | 0.03-0.5 | 0.25-1 | 96 |
| catarrhalis (untyped)b | |||
| β-Lactamase + | ≤0.03-0.25 | 0.12-0.5 | 100 |
| β-Lactamase - | ≤0.008-0.03 | 0.015-0.06 | 100 |
b Including both β-lactamase-positive and -negative strains.
MIC50/90=mean minimum inhibitory concentrations required to inhibit the growth of 50% or 90% of bacterial strains; MS=susceptible to meticillin; PI=intermediate susceptibility to penicillin; PR=resistant to penicillin; PS=susceptible to penicillin.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| Cefditoren (mg/kg) | C0 (μg/ml) | t1/2 (h) | AUClast (μg× h/ml) | Tlast (h) |
| 6.25 | 53.0 | 0.9 | 30.4 | 6 |
| 12.5 | 168.4 | 1.1 | 64.1 | 8 |
| 25 | 232.5 | 0.9 | 101.3 | 8 |
| 50 | 290.6 | 1.1 | 124.4 | 8 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 117467-28-4
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Appearance Solid
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분자량 620.72
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화학식 C25H28N6O7S3
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Color Light yellow to yellow
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SMILES
O=C(C(N12)=C(/C=C\C3=C(C)N=CS3)CS[C@]2([H])[C@H](NC(/C(C4=CSC(N)=N4)=N\OC)=O)C1=O)OCOC(C(C)(C)C)=O
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Synonyms
Cefditoren pivoxyl; Cefditoren pivaloyloxymethyl ester; ME 1207
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
용액&용해도
DMSO : ≥ 100 mg/mL (161.10 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
순도&문서
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Data Sheet (281 KB)
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SDS (419 KB)
- English - EN (419 KB)
- Français - FR (419 KB)
- Deutsch - DE (419 KB)
- Norwegian - NO (419 KB)
- Español - ES (419 KB)
- Swedish - SV (419 KB)
- Italian - IT (419 KB)
- Korean - KR (419 KB)
- Portuguese - PT (419 KB)
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Handling Instructions (2659 KB)
References
[1]. Wellington K, et al. Cefditoren pivoxil: a review of its use in the treatment of bacterial infections. Drugs. 2004;64(22):2597-618. [Content Brief]
[2]. Cafini F, et al. Enhanced in vivo activity of cefditoren in pre-immunized mice against penicillin-resistant S. pneumoniae (serotypes 6B, 19F and 23F) in a sepsis model. PLoS One. 2010 Aug 10;5(8):e12041. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.6110 mL | 8.0552 mL | 16.1103 mL | 40.2758 mL |
| 5 mM | 0.3222 mL | 1.6110 mL | 3.2221 mL | 8.0552 mL | |
| 10 mM | 0.1611 mL | 0.8055 mL | 1.6110 mL | 4.0276 mL | |
| 15 mM | 0.1074 mL | 0.5370 mL | 1.0740 mL | 2.6851 mL | |
| 20 mM | 0.0806 mL | 0.4028 mL | 0.8055 mL | 2.0138 mL | |
| 25 mM | 0.0644 mL | 0.3222 mL | 0.6444 mL | 1.6110 mL | |
| 30 mM | 0.0537 mL | 0.2685 mL | 0.5370 mL | 1.3425 mL | |
| 40 mM | 0.0403 mL | 0.2014 mL | 0.4028 mL | 1.0069 mL | |
| 50 mM | 0.0322 mL | 0.1611 mL | 0.3222 mL | 0.8055 mL | |
| 60 mM | 0.0269 mL | 0.1343 mL | 0.2685 mL | 0.6713 mL | |
| 80 mM | 0.0201 mL | 0.1007 mL | 0.2014 mL | 0.5034 mL | |
| 100 mM | 0.0161 mL | 0.0806 mL | 0.1611 mL | 0.4028 mL |
Cefditoren Pivoxil Related Classifications
HY-17452A Related Classifications
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