AMG 7905 TFA
Based on 1 Customer Validation
AMG 7905 TFA is a hypothermia-inducing transient receptor potential vanilloid type 1 (TRPV1) antagonist. AMG 7905 TFA potentiates TRPV1 channels activation by protons and drives the reflectory inhibition of thermogenesis and tail-skin vasoconstriction, while potently blocking channel activation by capsaicin.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity: 99.06%
- 화학식: C27H25F6N5O2S
- 분자량:597.58
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보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
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High-Throughput Bioactive Compound Library
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Biological Activity
Chemical Information
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Appearance Solid
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분자량 597.58
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화학식 C27H25F6N5O2S
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Color Light yellow to yellow
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SMILES
OC(C(F)(F)F)=O.FC(F)(C1=CC(NCC2CCCCC2)=C(C3=CC(NC4=CC5=C(N=CS5)C=C4)=NC=N3)C=C1)F
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
용액&용해도
DMSO : ≥ 100 mg/mL (167.34 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (274 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Garami A, et al. TRPV1 antagonists that cause hypothermia, instead of hyperthermia, in rodents: Compounds' pharmacological profiles, in vivo targets, thermoeffectors recruited and implications for drug development. Acta Physiol (Oxf). 2018 Jul;223(3):e13038. [Content Brief]
[2]. Lehto SG, et al. Antihyperalgesic effects of (R,E)-N-(2-hydroxy-2,3-dihydro-1H-inden-4-yl)-3-(2-(piperidin-1-yl)-4-(trifluoromethyl)phenyl)-acrylamide (AMG8562), a novel transient receptor potential vanilloid type 1 modulator that does not cause hyperthermia in rats. J Pharmacol Exp Ther. 2008 Jul;326(1):218-29. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.6734 mL | 8.3671 mL | 16.7342 mL | 41.8354 mL |
| 5 mM | 0.3347 mL | 1.6734 mL | 3.3468 mL | 8.3671 mL | |
| 10 mM | 0.1673 mL | 0.8367 mL | 1.6734 mL | 4.1835 mL | |
| 15 mM | 0.1116 mL | 0.5578 mL | 1.1156 mL | 2.7890 mL | |
| 20 mM | 0.0837 mL | 0.4184 mL | 0.8367 mL | 2.0918 mL | |
| 25 mM | 0.0669 mL | 0.3347 mL | 0.6694 mL | 1.6734 mL | |
| 30 mM | 0.0558 mL | 0.2789 mL | 0.5578 mL | 1.3945 mL | |
| 40 mM | 0.0418 mL | 0.2092 mL | 0.4184 mL | 1.0459 mL | |
| 50 mM | 0.0335 mL | 0.1673 mL | 0.3347 mL | 0.8367 mL | |
| 60 mM | 0.0279 mL | 0.1395 mL | 0.2789 mL | 0.6973 mL | |
| 80 mM | 0.0209 mL | 0.1046 mL | 0.2092 mL | 0.5229 mL | |
| 100 mM | 0.0167 mL | 0.0837 mL | 0.1673 mL | 0.4184 mL |
AMG 7905 TFA Related Classifications
HY-113654A Related Classifications
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