Cibotercept
Based on 1 Customer Validation
Cibotercept (KER-012) is a novel, modified, investigational activin receptor type IIB (ActRIIB) ligand trap designed to target select TGF-β ligands, including activins A and B, GDFs 8 and 11, to rebalance the defective activin receptor type II signaling observed in PAH.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity: 99.85%
- CAS No.: 2769700-97-0
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
FPIA_[PROTEIN]2-FC
MSTN/INHBA/GDF11
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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FPIA_[PROTEIN]2-FC
ELISA, FACS, Functional assay
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Immobilized Activin A Protein, Human/Mouse/Rat (HEK293, HY-P70311) can bind Cibotercept. The EC50 for this effect is 32.97 ng/mL. -
Immobilized GDF-11/BMP-11 Protein, Human (HEK293, solution, HY-P70222Y) can bind Cibotercept. The EC50 for this effect is 66.34 ng/mL.
Chemical Information
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CAS No. 2769700-97-0
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Appearance Liquid
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Color Colorless to light yellow
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Synonyms
KER-012
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선적
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
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Data Sheet (255 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)