DPPE-PEG2000-CTP

DPPE-PEG2000-CTP is specifically designed for active targeting nanomedicine applications. It can be incorporated into liposomes, lipid nanoparticles (LNPs), or other nanocarriers to confer ligand-directed targeting capability against brain endothelial cell receptors/CNS-specific transport mechanisms.
Composition and role of each component:
1. DPPE (dipalmitoylphosphatidylethanolamine): Lipid anchoring group-inserts into the lipid bilayer of liposomes/LNPs, providing stable membrane anchorage; its saturated C16 chains confer bilayer rigidity.
2. PEG2000 (polyethylene glycol, MW 2000): Hydrophilic polymer spacer arm that forms a steric corona around nanoparticles, reducing opsonization and reticuloendothelial system (RES) clearance, prolonging circulation half-life, and providing spatial separation between the lipid surface and targeting ligand.
3. CTP: Targeting ligand-can be reversibly linked (e.g., via enolase, thiol groups) to a carrier (e.g., miRNA), thereby enabling specific delivery to cardiomyocytes rather than all other organs.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.