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Cat. No.: HY-161787

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G9a-IN-2

G9a-IN-2 (Compound 7i) is an inhibitor for histone methyltransferases G9a with IC₅₀ of 0.024 μM. G9a-IN-2 reduces H3K9me2 levels and induces the mRNA expression of γ-globin mRNA. G9a-IN-2 shows the potential in ameliorating sickle cell disease (SCD).

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CAS No.: 2648853-26-1
화학식: C₃₀H₄₂N₄O₄
분자량:522.68

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

G9a-IN-2 Chemical Structure

CAS No.: 2648853-26-1

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

제품 설명

All Histone Methyltransferase Isoforms :

Chemical Information

CAS No. 2648853-26-1
분자량 522.68
화학식 C₃₀H₄₂N₄O₄
SMILES

CN(CC1)CCC1OC2=CC=C(NC([C@@H](NC(C3=C(C)C(C(CC(C)(C)C4)=O)=C4N3)=O)CCCC)=O)C=C2
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Nishigaya Y, et al., Structure-based development of novel substrate-type G9a inhibitors as epigenetic modulators for sickle cell disease treatment. Bioorg Med Chem Lett. 2024 Jun 22;110:129856. [Content Brief]

Calculators

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Mass Mass

Concentration Concentration

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Biological Activity
- 제품 설명
Chemical Information
순도&문서
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G9a-IN-2

All Histone Methyltransferase Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

G9a-IN-2 Related Classifications

HY-161787 Related Classifications