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Cat. No.: HY-183935

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NDM-1-IN-13

NDM-1-IN-13 is a NDM-1 inhibitor with an IC₅₀ of 3.27 μM. As an Antibiotic synergist, NDM-1-IN-13 synergistically reduces the minimum inhibitory concentration of Meropenem (HY-13678) against NDM-1-positive bacterial isolates. NDM-1-IN-13 can be used in studies related to NDM-1-positive bacterial infections.

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화학식: C₁₅H₁₂N₂O₄SSe
분자량:395.29

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

NDM-1-IN-13 Chemical Structure

사이즈

가격

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수량

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All Beta-lactamase Isoforms :

All Antibiotic Isoforms :

In Vitro

NDM-1-IN-13 (Compound 16a) inhibits NDM-1 with an IC₅₀ value of 3.27 μM^[1].
Combination of NDM-1-IN-13 with Meropenem (HY-13678) synergistically reduces the MIC of Meropenem (by 8- to 16-fold) against NDM-1-positive isolates^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Combination treatment with NDM-1-IN-13 (32 mg/kg; i.p.) and Meropenem significantly improves the survival rate of mice infected with Escherichia coli EC53, and restores the antibacterial effect of Meropenem against NDM-1-positive Escherichia coli EC53^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

분자량 395.29
화학식 C₁₅H₁₂N₂O₄SSe
SMILES

O=C(O)C1=C(C)CS[C@](N1C2=O)([H])[C@@H]2N3[Se]C4=CC=CC=C4C3=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Liu W, et al. The New Delhi Metallo-β-lactamase-1 Covalent Inhibitors Derived from Cephalexin Effectively Reverse Meropenem Resistance. J Med Chem. 2026;69(10):12398-12416. [Content Brief]

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- In Vitro
- In Vivo
Chemical Information
순도&문서
References

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NDM-1-IN-13

All Beta-lactamase Isoforms

All Antibiotic Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

NDM-1-IN-13 Related Classifications

HY-183935 Related Classifications