2. Membrane Transporter/Ion Channel Neuronal Signaling GPCR/G Protein
  3. Calcium Channel 5-HT Receptor
  4. Levemopamil

Levemopamil is a calcium channel blocker and 5-HT2 receptor antagonist. Levemopamil exerts renoprotective effects against ischemic acute kidney injury. Levemopamil is applicable to research related to ischemic acute renal failure.

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Levemopamil

Levemopamil Chemical Structure

CAS No. : 101238-51-1

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Description

Levemopamil is a calcium channel blocker and 5-HT2 receptor antagonist. Levemopamil exerts renoprotective effects against ischemic acute kidney injury. Levemopamil is applicable to research related to ischemic acute renal failure[1].

In Vivo

Levemopamil (6 mg/kg/h; intravenous administration; continuous infusion; 7 h) transiently converts oliguria to non-oliguria, maintains low-level glomerular filtration function, and protects cortical mitochondrial ATP synthesis in a rat model of oliguric ischemic acute kidney injury[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague-Dawley (female, adult, 191-239 g, left unilateral renal artery occlusion for 1 hour followed by 6 hours of reperfusion/reflow)[1]
Dosage: 6 mg/kg/h
Administration: i.v.; continuous infusion; from 1 hour before ischaemia until 6 hours after reflow
Result: Significantly increased urine flow and maintained measurable endogenous creatinine clearance in the ischaemic left kidney at 2 and 6 h of reperfusion.
Largely preserved mitochondrial ATP synthesis and normal ADP/O ratio.
Slightly attenuated the rise in cortical mitochondrial calcium content.
Molecular Weight

334.50

Formula

C23H30N2
CAS No.
SMILES

CN(CCC1=CC=CC=C1)CCC[C@@](C#N)(C2=CC=CC=C2)C(C)C
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Room temperature in continental US; may vary elsewhere.
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Purity & Documentation
References
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Keywords:

Levemopamil101238-51-1Calcium Channel5-HT ReceptorCa2+ channelsCa channelsSerotonin Receptor5-hydroxytryptamine Receptorrat kidneysischaemic acute renal failureischaemic kidneysconscious ratsInhibitorinhibitorinhibit

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