2. PROTAC Epigenetics Cell Cycle/DNA Damage
  3. PROTACs Aurora Kinase
  4. M9101

M9101 is a selective Aurora A PROTAC degrader with a DC50 of 2.3 nM. M9101 induces G2/M arrest in triple-negative breast cancer cells and potently inhibits the proliferation of multiple tumor cell lines. M9101 can be used in the research of various cancers including triple-negative breast cancer.
(Pink: Aurora A Target protein ligand; Blue: Cereblon ligand (HY-W248665); Black: linker).

For research use only. We do not sell to patients.

M9101

M9101 Chemical Structure

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

M9101 Related Antibodies

Top Publications Citing Use of Products

View All PROTACs Isoform Specific Products:

View All Isoforms
von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

View All Aurora Kinase Isoform Specific Products:

View All Isoforms
Aurora Kinase Aurora A Aurora B Aurora C

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

M9101 is a selective Aurora A PROTAC degrader with a DC50 of 2.3 nM. M9101 induces G2/M arrest in triple-negative breast cancer cells and potently inhibits the proliferation of multiple tumor cell lines. M9101 can be used in the research of various cancers including triple-negative breast cancer[1]. (Pink: Aurora A Target protein ligand; Blue: Cereblon ligand (HY-W248665); Black: linker).

IC50 & Target[1]

Aurora A

2.3 nM (DC50)

Aurora B

> 1 μM (DC50)

Cereblon

 

In Vitro

M9101 (0.01-1000 nM; 4 h) induces selective, dose-dependent degradation of Aurora A in BT549 and BT20 triple-negative breast cancer cells[1].
M9101 (10-100 nM; 4 h) exhibits high selectivity for Aurora A in MDA-MB-231 cells, with significant degradation of only Aurora A observed in a global proteomic analysis of 4680 proteins, and no degradation of known TP0903 off-target kinases[1].
M9101 (graded concentrations; 72 h) potently inhibits the proliferation of multiple cancer cell lines, with IC50 values ranging from 11.7 nM to 80.1 nM across tested models including triple-negative breast cancer, non-small cell lung cancer, prostate cancer, melanoma, multiple myeloma, bladder cancer, lymphoma, and rhabdomyosarcoma[1].
M9101 (indicated concentrations; 12 h) induces dose-dependent G2/M phase accumulation in MDA-MB-231 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

M9101 Related Antibodies

Western Blot Analysis[1]

Cell Line: BT549 and BT20 triple-negative breast cancer cells
Concentration: 0.01, 0.1, 0.3, 1, 3, 10, 30, 100, 300 and 1000 nM
Incubation Time: 4 h
Result: Induced selective, dose-dependent degradation of Aurora A in both BT549 and BT20 cells.
Caused no significant degradation of Aurora B across the tested concentrations.

Cell Cycle Analysis[1]

Cell Line: MDA-MB-231 triple-negative breast cancer cells
Concentration: 10 and 100 nM
Incubation Time: 12 h
Result: Induced dose-dependent accumulation of cells in the G2/M phase, a phenotype more pronounced than that caused by the catalytic inhibitor alisertib.
In Vivo

M9101 (10-20 mg/kg; i.p.; daily; 5 days) selectively degrades Aurora A in MDA-MB-231 xenograft tumors, achieving 86.9% and 94.2% maximum degradation at 10 mg/kg and 20 mg/kg, respectively, with minimal Aurora B degradation and no detectable body weight changes[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: CB17/SCID (female, 6 to 8 weeks old, subcutaneous xenograft model)[1]
Dosage: 10 mg/kg; 20 mg/kg
Administration: i.p.; daily; 5 consecutive days
Result: Induced 86.9% maximum degradation of Aurora A and 59.8% maximum degradation of Aurora B in tumor tissue at 10 mg/kg.
Induced 94.2% maximum degradation of Aurora A and 62.1% maximum degradation of Aurora B in tumor tissue at 20 mg/kg.
Caused no obvious changes in body weight with either dose.
Molecular Weight

784.28

Formula

C38H38ClN9O6S
SMILES

O=C1NC(CCC1N2C(C3=CC4=C(C=C3C2=O)CN(C4)C5CCN(CC5)C6=CC=C(NC7=NC=C(Cl)C(NC8=CC=CC=C8S(N(C)C)(=O)=O)=N7)C=C6)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

M9101 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

M9101M 9101M-9101PROTACsAurora Kinaseprostate cancerAurora Anon-small cell lung cancerrhabdomyosarcomabladder cancertriple-negative breast cancerlymphomamelanomamultiple myelomaMDA-MB-231 cellsInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
M9101
Cat. No.:
HY-184193
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.