2. Others Metabolic Enzyme/Protease
  3. Environmental Pollutants Cytochrome P450 Herbicide
  4. MCPA

MCPA is an orally active phenoxyacetic acid herbicide. MCPA interferes with membrane integrity, energy metabolism (decreases ATP levels), and redox balance in plant cells. MCPA increases hepatic cytochrome P-450 levels and increases aniline hydroxylase and 7-ethoxycoumarin O-deethylase activities. MCPA can be used to control broadleaf weeds.

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MCPA

MCPA Chemische Struktur

CAS. Nr. : 94-74-6

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Solution
10 mM * 1 mL in DMSO Auf Lager
Solid
500 mg Auf Lager
1 g Auf Lager
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10 g   Angebot einholen  

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Based on 1 publication(s) in Google Scholar

Other Forms of MCPA:

MCPA Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE MCPA

Alle Cytochrome P450 Isoform-spezifische Produkte anzeigen:

Alle Isoformen anzeigen
CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP1A2 CYP2D6 CYP2C9 CYP2C19 CYP3A CYP3A4 CYP17A1

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Beschreibung

MCPA is an orally active phenoxyacetic acid herbicide. MCPA interferes with membrane integrity, energy metabolism (decreases ATP levels), and redox balance in plant cells. MCPA increases hepatic cytochrome P-450 levels and increases aniline hydroxylase and 7-ethoxycoumarin O-deethylase activities. MCPA can be used to control broadleaf weeds[1][2][3][4][5].

In Vitro

MCPA (50 μM) is taken up by Caco-2 cells mainly via monocarboxylic acid transporters shared with benzoic acid and partially via L-lactic acid[1].
MCPA (20-120 μM; 4 weeks) inhibits growth of non-green potato tuber calli, disrupts membrane integrity, reduces energy charge, and affects redox state and antioxidant enzyme activities[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MCPA Related Antibodies
In Vivo

MCPA (200 mg/kg/day; p.o.; 2 weeks) increases hepatic cytochrome P-450 level and activities of aniline hydroxylase and 7-ethoxycoumarin O-deethylase in male rats[4].
MCPA (14C-MCPA; 5-100 mg/kg; p.o.; single or multiple doses) is rapidly absorbed and excreted mainly in urine in rats, with limited metabolism to HMCPA and glycine conjugate[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molekulargewicht

200.62

Formel

C9H9ClO3
CAS. Nr.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(O)COC1=CC=C(Cl)C=C1C
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Lösungsmittel & Löslichkeit
In Vitro: 

DMSO : 50 mg/mL (249.23 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.9845 mL 24.9227 mL 49.8455 mL
5 mM 0.9969 mL 4.9845 mL 9.9691 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molaritätsrechner

  • Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (12.46 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (12.46 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Reinheit & Dokumentation
Verweise

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.9845 mL 24.9227 mL 49.8455 mL 124.6137 mL
5 mM 0.9969 mL 4.9845 mL 9.9691 mL 24.9227 mL
10 mM 0.4985 mL 2.4923 mL 4.9845 mL 12.4614 mL
15 mM 0.3323 mL 1.6615 mL 3.3230 mL 8.3076 mL
20 mM 0.2492 mL 1.2461 mL 2.4923 mL 6.2307 mL
25 mM 0.1994 mL 0.9969 mL 1.9938 mL 4.9845 mL
30 mM 0.1662 mL 0.8308 mL 1.6615 mL 4.1538 mL
40 mM 0.1246 mL 0.6231 mL 1.2461 mL 3.1153 mL
50 mM 0.0997 mL 0.4985 mL 0.9969 mL 2.4923 mL
60 mM 0.0831 mL 0.4154 mL 0.8308 mL 2.0769 mL
80 mM 0.0623 mL 0.3115 mL 0.6231 mL 1.5577 mL
100 mM 0.0498 mL 0.2492 mL 0.4985 mL 1.2461 mL
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MCPA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MCPA94-74-6Environmental PollutantsCytochrome P450HerbicideEnvironmental ContaminantsCYPsratsherbicidebroadleaf weedsInhibitorinhibitorinhibit

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