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Cat. No.: HY-140519

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N-(Azido-PEG4)-N-bis(PEG4-acid)

Name: N-(Azido-PEG4)-N-bis(PEG4-acid)
Brand: MedChemExpress
SKU: HY-140519
Price: 149.00 USD
Availability: InStock
Rating: 5 (1 reviews)

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N-(Azido-PEG4)-N-bis(PEG4-acid) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-(Azido-PEG4)-N-bis(PEG4-acid) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

For research use only. We do not sell to patients.

CAS No.: 2093152-80-6
Formula: C₃₂H₆₂N₄O₁₆
Molecular Weight:758.85

Storage:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Data Sheet (263 KB)

N-(Azido-PEG4)-N-bis(PEG4-acid) Chemical Structure

CAS No.: 2093152-80-6

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

N-(Azido-PEG4)-N-bis(PEG4-acid) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs^[1]. N-(Azido-PEG4)-N-bis(PEG4-acid) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

IC₅₀ & Target

PEGs

All PROTAC Linkers Isoforms :

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2093152-80-6
Appearance Liquid
Molecular Weight 758.85
Formula C₃₂H₆₂N₄O₁₆
Color Colorless to light yellow
SMILES

OC(CCOCCOCCOCCOCCN(CCOCCOCCOCCOCCN=[N+]=[N-])CCOCCOCCOCCOCCC(O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (263 KB)
SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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N-(Azido-PEG4)-N-bis(PEG4-acid)

N-(Azido-PEG3)-N-bis(PEG4-acid)

N-(Azido-PEG3)-N-(PEG2-NH-Boc)-PEG3-acid

N-(Azido-PEG2)-N-bis(PEG4-Boc)

N-(Azido-PEG3)-N-bis(PEG3-acid)

N-(Azido-PEG4)-N-bis(PEG4-NHS ester)

All PROTAC Linkers Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Bioz

N-(Azido-PEG4)-N-bis(PEG4-acid)

N-(Azido-PEG3)-N-bis(PEG4-acid)

N-(Azido-PEG3)-N-(PEG2-NH-Boc)-PEG3-acid

N-(Azido-PEG2)-N-bis(PEG4-Boc)

N-(Azido-PEG3)-N-bis(PEG3-acid)

N-(Azido-PEG4)-N-bis(PEG4-NHS ester)

All PROTAC Linkers Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

N-(Azido-PEG4)-N-bis(PEG4-acid) Related Classifications

HY-140519 Related Classifications

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